CDYL — 64 ClinVar variants
All ClinVar germline CDYL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Benign · 1 Likely benign · 62 Uncertain significance
Full CDYL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDYL p.Ala136Val Uncertain significance Single submitter
- CDYL p.Ala154Thr Uncertain significance Single submitter
- CDYL p.Ala182Ser Uncertain significance Single submitter
- CDYL p.Ala183Val Uncertain significance Single submitter
- CDYL p.Ala195Thr Uncertain significance Single submitter
- CDYL p.Ala527Ser Uncertain significance Single submitter
- CDYL p.Arg11Lys Uncertain significance Single submitter
- CDYL p.Arg120Gly Uncertain significance Single submitter
- CDYL p.Arg130Gln Uncertain significance Single submitter
- CDYL p.Asn242Asp Uncertain significance Single submitter
- CDYL p.Asn242Ser Uncertain significance Single submitter
- CDYL p.Asn78His Uncertain significance Single submitter
- CDYL p.Asp14Glu Uncertain significance Single submitter
- CDYL p.Asp263Gly Uncertain significance Single submitter
- CDYL p.Asp331Asn Uncertain significance Single submitter
- CDYL p.Asp542Asn Uncertain significance Single submitter
- CDYL p.Gln82Glu Uncertain significance Single submitter
- CDYL p.Glu170Lys Uncertain significance Single submitter
- CDYL p.Glu180Gln Uncertain significance Single submitter
- CDYL p.Glu514Lys Uncertain significance Single submitter
- CDYL p.Gly157Ser Uncertain significance Single submitter
- CDYL p.Gly188Arg Uncertain significance Single submitter
- CDYL p.Gly192Val Uncertain significance Single submitter
- CDYL p.Gly194Ser Uncertain significance Single submitter
- CDYL p.Gly215Ser Uncertain significance Single submitter
- CDYL p.Ile247Met Uncertain significance Single submitter
- CDYL p.Leu127Phe Uncertain significance Single submitter
- CDYL p.Lys103Gln Uncertain significance Single submitter
- CDYL p.Lys260Arg Uncertain significance Single submitter
- CDYL p.Met133Thr Uncertain significance Single submitter
- CDYL p.Met221Val Uncertain significance Single submitter
- CDYL p.Met236Leu Uncertain significance Single submitter
- CDYL p.Pro211Ser Uncertain significance Single submitter
- CDYL p.Pro216Arg Uncertain significance Single submitter
- CDYL p.Ser138Thr Uncertain significance Single submitter
- CDYL p.Ser160Gly Uncertain significance Single submitter
- CDYL p.Ser160Ile Uncertain significance Single submitter
- CDYL p.Ser451Gly Uncertain significance Single submitter
- CDYL p.Ser488Leu Uncertain significance Single submitter
- CDYL p.Ser526Leu Uncertain significance Single submitter
- CDYL p.Ser532Phe Uncertain significance Single submitter
- CDYL p.Thr218Ala Uncertain significance Single submitter
- CDYL p.Thr240Ala Uncertain significance Single submitter
- CDYL p.Thr359Ala Uncertain significance Single submitter
- CDYL p.Thr367Ile Uncertain significance Single submitter
- CDYL p.Thr69Ala Uncertain significance Single submitter
- CDYL p.Thr87Ile Uncertain significance Single submitter
- CDYL p.Val481Ile Uncertain significance Single submitter
- CDYL p.Val492Leu Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CDYL p.Ala329Thr Uncertain significance Single submitter
- CDYL p.Arg130Trp Uncertain significance Single submitter
- CDYL p.Arg357Cys Uncertain significance Single submitter
- CDYL p.Arg502His Uncertain significance Single submitter
- CDYL p.Arg58Cys Uncertain significance Single submitter
- CDYL p.Asp33Ala Uncertain significance Single submitter
- CDYL p.Gln528His Uncertain significance Single submitter
- CDYL p.Gln63Pro Uncertain significance Single submitter
- CDYL p.Gly229Arg Uncertain significance Single submitter
- CDYL p.Phe235Leu Uncertain significance Single submitter
- CDYL p.Ser92Cys Uncertain significance Single submitter
- CDYL p.Val149Phe Uncertain significance Single submitter
- CDYL p.Val341Ile Uncertain significance Single submitter
All CDYL variants
Benign 1
- c.1332+31dup Single submitter
Likely benign 1
- p.Asn246Ser Single submitter
Uncertain significance 62
- p.Ala136Val Single submitter ⚠
- p.Ala154Thr Single submitter ⚠
- p.Ala182Ser Single submitter ⚠
- p.Ala183Val Single submitter ⚠
- p.Ala195Thr Single submitter ⚠
- p.Ala329Thr Single submitter ⚠
- p.Ala527Ser Single submitter ⚠
- p.Arg11Lys Single submitter ⚠
- p.Arg120Gly Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg130Trp Single submitter ⚠
- p.Arg357Cys Single submitter ⚠
- p.Arg502His Single submitter ⚠
- p.Arg58Cys Single submitter ⚠
- p.Asn242Asp Single submitter ⚠
- p.Asn242Ser Single submitter ⚠
- p.Asn78His Single submitter ⚠
- p.Asp14Glu Single submitter ⚠
- p.Asp263Gly Single submitter ⚠
- p.Asp331Asn Single submitter ⚠
- p.Asp33Ala Single submitter ⚠
- p.Asp542Asn Single submitter ⚠
- p.Gln528His Single submitter ⚠
- p.Gln63Pro Single submitter ⚠
- p.Gln82Glu Single submitter ⚠
- p.Glu170Lys Single submitter ⚠
- p.Glu180Gln Single submitter ⚠
- p.Glu514Lys Single submitter ⚠
- p.Gly157Ser Single submitter ⚠
- p.Gly188Arg Single submitter ⚠
- p.Gly192Val Single submitter ⚠
- p.Gly194Ser Single submitter ⚠
- p.Gly215Ser Single submitter ⚠
- p.Gly229Arg Single submitter ⚠
- p.Ile247Met Single submitter ⚠
- p.Leu127Phe Single submitter ⚠
- p.Lys103Gln Single submitter ⚠
- p.Lys260Arg Single submitter ⚠
- p.Met133Thr Single submitter ⚠
- p.Met221Val Single submitter ⚠
- p.Met236Leu Single submitter ⚠
- p.Phe235Leu Single submitter ⚠
- p.Pro211Ser Single submitter ⚠
- p.Pro216Arg Single submitter ⚠
- p.Ser138Thr Single submitter ⚠
- p.Ser160Gly Single submitter ⚠
- p.Ser160Ile Single submitter ⚠
- p.Ser451Gly Single submitter ⚠
- p.Ser488Leu Single submitter ⚠
- p.Ser526Leu Single submitter ⚠
- p.Ser532Phe Single submitter ⚠
- p.Ser92Cys Single submitter ⚠
- p.Thr218Ala Single submitter ⚠
- p.Thr240Ala Single submitter ⚠
- p.Thr359Ala Single submitter ⚠
- p.Thr367Ile Single submitter ⚠
- p.Thr69Ala Single submitter ⚠
- p.Thr87Ile Single submitter ⚠
- p.Val149Phe Single submitter ⚠
- p.Val341Ile Single submitter ⚠
- p.Val481Ile Single submitter ⚠
- p.Val492Leu Single submitter ⚠