CDYL2 — 73 ClinVar variants
All ClinVar germline CDYL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
2 Benign · 1 Likely benign · 70 Uncertain significance
Full CDYL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDYL2 p.Ala114Gly Uncertain significance Single submitter
- CDYL2 p.Ala114Thr Uncertain significance Single submitter
- CDYL2 p.Ala334Thr Uncertain significance Single submitter
- CDYL2 p.Ala362Thr Uncertain significance Single submitter
- CDYL2 p.Ala384Thr Uncertain significance Single submitter
- CDYL2 p.Arg106Gln Uncertain significance Single submitter
- CDYL2 p.Arg330Gln Uncertain significance Single submitter
- CDYL2 p.Arg330Trp Uncertain significance Single submitter
- CDYL2 p.Arg387Cys Uncertain significance Single submitter
- CDYL2 p.Arg387His Uncertain significance Single submitter
- CDYL2 p.Arg415Trp Uncertain significance Single submitter
- CDYL2 p.Arg444Trp Uncertain significance Single submitter
- CDYL2 p.Arg464Gln Uncertain significance Single submitter
- CDYL2 p.Arg82Gln Uncertain significance Single submitter
- CDYL2 p.Asn196Thr Uncertain significance Single submitter
- CDYL2 p.Asn289Ser Uncertain significance Single submitter
- CDYL2 p.Asp166Glu Uncertain significance Single submitter
- CDYL2 p.Asp183Glu Uncertain significance Single submitter
- CDYL2 p.Asp501Gly Uncertain significance Single submitter
- CDYL2 p.Cys479Tyr Uncertain significance Single submitter
- CDYL2 p.Gln242Pro Uncertain significance Single submitter
- CDYL2 p.Gln400Lys Uncertain significance Single submitter
- CDYL2 p.Gln484His Uncertain significance Single submitter
- CDYL2 p.Glu227Gly Uncertain significance Single submitter
- CDYL2 p.Glu282Asp Uncertain significance Single submitter
- CDYL2 p.Glu421Gly Uncertain significance Single submitter
- CDYL2 p.Glu458Lys Uncertain significance Single submitter
- CDYL2 p.Gly143Ser Uncertain significance Single submitter
- CDYL2 p.Gly162Ser Uncertain significance Single submitter
- CDYL2 p.Gly171Arg Uncertain significance Single submitter
- CDYL2 p.Gly318Ser Uncertain significance Single submitter
- CDYL2 p.His262Tyr Uncertain significance Single submitter
- CDYL2 p.Ile52Thr Uncertain significance Single submitter
- CDYL2 p.Leu200Val Uncertain significance Single submitter
- CDYL2 p.Leu311Val Uncertain significance Single submitter
- CDYL2 p.Leu480Val Uncertain significance Single submitter
- CDYL2 p.Lys118Arg Uncertain significance Single submitter
- CDYL2 p.Lys165Arg Uncertain significance Single submitter
- CDYL2 p.Pro356Thr Uncertain significance Single submitter
- CDYL2 p.Pro41Leu Uncertain significance Single submitter
- CDYL2 p.Pro84Leu Uncertain significance Single submitter
- CDYL2 p.Pro96Leu Uncertain significance Single submitter
- CDYL2 p.Ser163Phe Uncertain significance Single submitter
- CDYL2 p.Ser239Arg Uncertain significance Single submitter
- CDYL2 p.Thr102Asn Uncertain significance Single submitter
- CDYL2 p.Thr389Met Uncertain significance Single submitter
- CDYL2 p.Tyr120Cys Uncertain significance Single submitter
- CDYL2 p.Val220Ala Uncertain significance Single submitter
- CDYL2 p.Val404Ile Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CDYL2 p.Ala286Val Uncertain significance Single submitter
- CDYL2 p.Ala341Gly Uncertain significance Single submitter
- CDYL2 p.Arg284Trp Uncertain significance Single submitter
- CDYL2 p.Asn56Ser Uncertain significance Single submitter
- CDYL2 p.Asp166Tyr Uncertain significance Single submitter
- CDYL2 p.Gln268His Uncertain significance Single submitter
- CDYL2 p.Gln420Arg Uncertain significance Single submitter
- CDYL2 p.Gly101Trp Uncertain significance Single submitter
- CDYL2 p.Gly212Trp Uncertain significance Single submitter
- CDYL2 p.Ile370Val Uncertain significance Single submitter
- CDYL2 p.Leu144Met Uncertain significance Single submitter
- CDYL2 p.Lys133Asn Uncertain significance Single submitter
- CDYL2 p.Lys234Arg Uncertain significance Single submitter
- CDYL2 p.Lys62Glu Uncertain significance Single submitter
- CDYL2 p.Phe342Leu Uncertain significance Single submitter
- CDYL2 p.Ser142Arg Uncertain significance Single submitter
- CDYL2 p.Ser207Tyr Uncertain significance Single submitter
- CDYL2 p.Thr269Ile Uncertain significance Single submitter
- CDYL2 p.Val351Leu Uncertain significance Single submitter
- CDYL2 p.Val404Phe Uncertain significance Single submitter
- CDYL2 p.Val470Leu Uncertain significance Single submitter
All CDYL2 variants
Likely benign 1
- p.Ser73Gly Single submitter
Uncertain significance 70
- p.Ala114Gly Single submitter ⚠
- p.Ala114Thr Single submitter ⚠
- p.Ala286Val Single submitter ⚠
- p.Ala334Thr Single submitter ⚠
- p.Ala341Gly Single submitter ⚠
- p.Ala362Thr Single submitter ⚠
- p.Ala384Thr Single submitter ⚠
- p.Arg106Gln Single submitter ⚠
- p.Arg284Trp Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg330Trp Single submitter ⚠
- p.Arg387Cys Single submitter ⚠
- p.Arg387His Single submitter ⚠
- p.Arg415Trp Single submitter ⚠
- p.Arg444Trp Single submitter ⚠
- p.Arg464Gln Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Asn196Thr Single submitter ⚠
- p.Asn289Ser Single submitter ⚠
- p.Asn56Ser Single submitter ⚠
- p.Asp166Glu Single submitter ⚠
- p.Asp166Tyr Single submitter ⚠
- p.Asp183Glu Single submitter ⚠
- p.Asp501Gly Single submitter ⚠
- p.Cys479Tyr Single submitter ⚠
- p.Gln242Pro Single submitter ⚠
- p.Gln268His Single submitter ⚠
- p.Gln400Lys Single submitter ⚠
- p.Gln420Arg Single submitter ⚠
- p.Gln484His Single submitter ⚠
- p.Glu227Gly Single submitter ⚠
- p.Glu282Asp Single submitter ⚠
- p.Glu421Gly Single submitter ⚠
- p.Glu458Lys Single submitter ⚠
- p.Gly101Trp Single submitter ⚠
- p.Gly143Ser Single submitter ⚠
- p.Gly162Ser Single submitter ⚠
- p.Gly171Arg Single submitter ⚠
- p.Gly212Trp Single submitter ⚠
- p.Gly318Ser Single submitter ⚠
- p.His262Tyr Single submitter ⚠
- p.Ile370Val Single submitter ⚠
- p.Ile52Thr Single submitter ⚠
- p.Leu144Met Single submitter ⚠
- p.Leu200Val Single submitter ⚠
- p.Leu311Val Single submitter ⚠
- p.Leu480Val Single submitter ⚠
- p.Lys118Arg Single submitter ⚠
- p.Lys133Asn Single submitter ⚠
- p.Lys165Arg Single submitter ⚠
- p.Lys234Arg Single submitter ⚠
- p.Lys62Glu Single submitter ⚠
- p.Phe342Leu Single submitter ⚠
- p.Pro356Thr Single submitter ⚠
- p.Pro41Leu Single submitter ⚠
- p.Pro84Leu Single submitter ⚠
- p.Pro96Leu Single submitter ⚠
- p.Ser142Arg Single submitter ⚠
- p.Ser163Phe Single submitter ⚠
- p.Ser207Tyr Single submitter ⚠
- p.Ser239Arg Single submitter ⚠
- p.Thr102Asn Single submitter ⚠
- p.Thr269Ile Single submitter ⚠
- p.Thr389Met Single submitter ⚠
- p.Tyr120Cys Single submitter ⚠
- p.Val220Ala Single submitter ⚠
- p.Val351Leu Single submitter ⚠
- p.Val404Ile Single submitter ⚠
- p.Val404Phe Single submitter ⚠
- p.Val470Leu Single submitter ⚠