CEACAM1 — 38 ClinVar variants
All ClinVar germline CEACAM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
7 Likely benign · 31 Uncertain significance
Full CEACAM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CEACAM1 p.Ala6Val Uncertain significance Single submitter
- CEACAM1 p.Ala83Thr Uncertain significance Single submitter
- CEACAM1 p.Cys215Tyr Uncertain significance Single submitter
- CEACAM1 p.Glu422Gly Uncertain significance Single submitter
- CEACAM1 p.His469Arg Uncertain significance Single submitter
- CEACAM1 p.Leu52Pro Uncertain significance Single submitter
- CEACAM1 p.Pro427Ser Uncertain significance Single submitter
- CEACAM1 p.Thr174Ala Uncertain significance Single submitter
- CEACAM1 p.Thr26Ile Uncertain significance Single submitter
- CEACAM1 p.Thr33Ser Uncertain significance Single submitter
- CEACAM1 p.Thr467Arg Uncertain significance Single submitter
- CEACAM1 p.Thr514Lys Uncertain significance Single submitter
- CEACAM1 p.Val441Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CEACAM1 p.Arg98Gln Uncertain significance Single submitter
- CEACAM1 p.Asn274Asp Uncertain significance Single submitter
- CEACAM1 p.Asn351Ser Uncertain significance Single submitter
- CEACAM1 p.Asn400Ser Uncertain significance Single submitter
- CEACAM1 p.Gln110His Uncertain significance Single submitter
- CEACAM1 p.Gln364His Uncertain significance Single submitter
- CEACAM1 p.Gly48Arg Uncertain significance Single submitter
- CEACAM1 p.Ile273Thr Uncertain significance Single submitter
- CEACAM1 p.Ile316Met Uncertain significance Single submitter
- CEACAM1 p.Leu191Arg Uncertain significance Single submitter
- CEACAM1 p.Lys341Thr Uncertain significance Single submitter
- CEACAM1 p.Lys69Gln Uncertain significance Single submitter
- CEACAM1 p.Pro186Gln Uncertain significance Single submitter
- CEACAM1 p.Ser151Asn Uncertain significance Single submitter
- CEACAM1 p.Ser154Phe Uncertain significance Single submitter
- CEACAM1 p.Trp179Ser Uncertain significance Single submitter
- CEACAM1 p.Val437Ala Uncertain significance Single submitter
All CEACAM1 variants
Likely benign 7
- p.Asn111= Multiple submitters
- p.Leu53= Multiple submitters
- p.Ala164Val Single submitter
- p.Ala6Thr Single submitter
- p.Arg459Gly Single submitter
- p.Asn482= Single submitter
- p.Met411Val Single submitter
Uncertain significance 31
- p.Ala6Val Single submitter ⚠
- p.Ala83Thr Single submitter ⚠
- p.Arg98Gln Single submitter ⚠
- p.Asn274Asp Single submitter ⚠
- p.Asn351Ser Single submitter ⚠
- p.Asn400Ser Single submitter ⚠
- p.Cys215Tyr Single submitter ⚠
- p.Gln110His Single submitter ⚠
- p.Gln364His Single submitter ⚠
- p.Glu422Gly Single submitter ⚠
- p.Gly48Arg Single submitter ⚠
- p.His469Arg Single submitter ⚠
- p.Ile273Thr Single submitter ⚠
- p.Ile316Met Single submitter ⚠
- p.Leu191Arg Single submitter ⚠
- p.Leu52Pro Single submitter ⚠
- p.Lys341Thr Single submitter ⚠
- p.Lys69Gln Single submitter ⚠
- p.Pro186Gln Single submitter ⚠
- p.Pro427Ser Single submitter ⚠
- p.Ser151Asn Single submitter ⚠
- p.Ser154Phe Single submitter ⚠
- p.Thr174Ala Single submitter ⚠
- p.Thr26Ile Single submitter ⚠
- p.Thr33Ser Single submitter ⚠
- p.Thr467Arg Single submitter ⚠
- p.Thr514Lys Single submitter ⚠
- p.Trp15Ter Single submitter
- p.Trp179Ser Single submitter ⚠
- p.Val437Ala Single submitter ⚠
- p.Val441Ile Single submitter ⚠