CEACAM21 — 51 ClinVar variants
All ClinVar germline CEACAM21 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
2 Likely benign · 49 Uncertain significance
Full CEACAM21 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CEACAM21 p.Ala22Val Uncertain significance Single submitter
- CEACAM21 p.Ala267Val Uncertain significance Single submitter
- CEACAM21 p.Asn61Asp Uncertain significance Single submitter
- CEACAM21 p.Asn76Ser Uncertain significance Single submitter
- CEACAM21 p.Asn76Thr Uncertain significance Single submitter
- CEACAM21 p.Asp226Glu Uncertain significance Single submitter
- CEACAM21 p.Asp269Asn Uncertain significance Single submitter
- CEACAM21 p.Gln150Lys Uncertain significance Single submitter
- CEACAM21 p.Gln276Glu Uncertain significance Single submitter
- CEACAM21 p.Glu60Lys Uncertain significance Single submitter
- CEACAM21 p.His136Tyr Uncertain significance Single submitter
- CEACAM21 p.His137Arg Uncertain significance Single submitter
- CEACAM21 p.Leu250Ile Uncertain significance Single submitter
- CEACAM21 p.Phe273Leu Uncertain significance Single submitter
- CEACAM21 p.Pro278Leu Uncertain significance Single submitter
- CEACAM21 p.Pro278Ser Uncertain significance Single submitter
- CEACAM21 p.Pro279Thr Uncertain significance Single submitter
- CEACAM21 p.Pro31Ser Uncertain significance Single submitter
- CEACAM21 p.Pro3Thr Uncertain significance Single submitter
- CEACAM21 p.Ser104Gly Uncertain significance Single submitter
- CEACAM21 p.Ser152Asn Uncertain significance Single submitter
- CEACAM21 p.Ser271Asn Uncertain significance Single submitter
- CEACAM21 p.Thr238Ala Uncertain significance Single submitter
- CEACAM21 p.Thr238Ile Uncertain significance Single submitter
- CEACAM21 p.Val55Leu Uncertain significance Single submitter
- CEACAM21 p.Val56Ala Uncertain significance Single submitter
- CEACAM21 p.Val88Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CEACAM21 p.Ala209Thr Uncertain significance Single submitter
- CEACAM21 p.Arg139Cys Uncertain significance Single submitter
- CEACAM21 p.Arg183Cys Uncertain significance Single submitter
- CEACAM21 p.Asp226Asn Uncertain significance Single submitter
- CEACAM21 p.Asp85Gly Uncertain significance Single submitter
- CEACAM21 p.Glu99Lys Uncertain significance Single submitter
- CEACAM21 p.Gly210Ala Uncertain significance Single submitter
- CEACAM21 p.Gly240Asp Uncertain significance Single submitter
- CEACAM21 p.Gly66Val Uncertain significance Single submitter
- CEACAM21 p.Gly97Ser Uncertain significance Single submitter
- CEACAM21 p.Ile201Val Uncertain significance Single submitter
- CEACAM21 p.Leu184Arg Uncertain significance Single submitter
- CEACAM21 p.Leu228Ile Uncertain significance Single submitter
- CEACAM21 p.Leu53Ile Uncertain significance Single submitter
- CEACAM21 p.Lys69Gln Uncertain significance Single submitter
- CEACAM21 p.Phe27Leu Uncertain significance Single submitter
- CEACAM21 p.Pro203His Uncertain significance Single submitter
- CEACAM21 p.Ser288Phe Uncertain significance Single submitter
- CEACAM21 p.Thr154Ile Uncertain significance Single submitter
- CEACAM21 p.Thr171Ile Uncertain significance Single submitter
- CEACAM21 p.Thr187Met Uncertain significance Single submitter
- CEACAM21 p.Val245Leu Uncertain significance Single submitter
All CEACAM21 variants
Likely benign 2
- p.Pro283= Single submitter
- p.Thr21Ile Single submitter
Uncertain significance 49
- p.Ala209Thr Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Ala267Val Single submitter ⚠
- p.Arg139Cys Single submitter ⚠
- p.Arg183Cys Single submitter ⚠
- p.Asn61Asp Single submitter ⚠
- p.Asn76Ser Single submitter ⚠
- p.Asn76Thr Single submitter ⚠
- p.Asp226Asn Single submitter ⚠
- p.Asp226Glu Single submitter ⚠
- p.Asp269Asn Single submitter ⚠
- p.Asp85Gly Single submitter ⚠
- p.Gln150Lys Single submitter ⚠
- p.Gln276Glu Single submitter ⚠
- p.Glu60Lys Single submitter ⚠
- p.Glu99Lys Single submitter ⚠
- p.Gly210Ala Single submitter ⚠
- p.Gly240Asp Single submitter ⚠
- p.Gly66Val Single submitter ⚠
- p.Gly97Ser Single submitter ⚠
- p.His136Tyr Single submitter ⚠
- p.His137Arg Single submitter ⚠
- p.Ile201Val Single submitter ⚠
- p.Leu184Arg Single submitter ⚠
- p.Leu228Ile Single submitter ⚠
- p.Leu250Ile Single submitter ⚠
- p.Leu53Ile Single submitter ⚠
- p.Lys69Gln Single submitter ⚠
- p.Phe273Leu Single submitter ⚠
- p.Phe27Leu Single submitter ⚠
- p.Pro203His Single submitter ⚠
- p.Pro278Leu Single submitter ⚠
- p.Pro278Ser Single submitter ⚠
- p.Pro279Thr Single submitter ⚠
- p.Pro31Ser Single submitter ⚠
- p.Pro3Thr Single submitter ⚠
- p.Ser104Gly Single submitter ⚠
- p.Ser152Asn Single submitter ⚠
- p.Ser271Asn Single submitter ⚠
- p.Ser288Phe Single submitter ⚠
- p.Thr154Ile Single submitter ⚠
- p.Thr171Ile Single submitter ⚠
- p.Thr187Met Single submitter ⚠
- p.Thr238Ala Single submitter ⚠
- p.Thr238Ile Single submitter ⚠
- p.Val245Leu Single submitter ⚠
- p.Val55Leu Single submitter ⚠
- p.Val56Ala Single submitter ⚠
- p.Val88Ile Single submitter ⚠