CEACAM3 — 53 ClinVar variants
All ClinVar germline CEACAM3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
8 Benign · 8 Likely benign · 37 Uncertain significance
Full CEACAM3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CEACAM3 p.Arg243Gln Uncertain significance Single submitter
- CEACAM3 p.Cys12Arg Uncertain significance Single submitter
- CEACAM3 p.Glu11Lys Uncertain significance Single submitter
- CEACAM3 p.His204Arg Uncertain significance Single submitter
- CEACAM3 p.His236Arg Uncertain significance Single submitter
- CEACAM3 p.Lys235Glu Uncertain significance Single submitter
- CEACAM3 p.Met41Ile Uncertain significance Single submitter
- CEACAM3 p.Phe208Val Uncertain significance Single submitter
- CEACAM3 p.Ser205Gly Uncertain significance Single submitter
- CEACAM3 p.Thr225Ser Uncertain significance Single submitter
- CEACAM3 p.Val80Ile Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- CEACAM3 p.Glu133Gly Benign Multiple submitters
- CEACAM3 p.Ala134Thr Uncertain significance Single submitter
- CEACAM3 p.Ala154Thr Uncertain significance Single submitter
- CEACAM3 p.Ala169Thr Uncertain significance Single submitter
- CEACAM3 p.Ala46Thr Uncertain significance Single submitter
- CEACAM3 p.Ala94Thr Uncertain significance Single submitter
- CEACAM3 p.Arg186Cys Uncertain significance Single submitter
- CEACAM3 p.Arg200Cys Uncertain significance Single submitter
- CEACAM3 p.Arg98Gln Uncertain significance Single submitter
- CEACAM3 p.Gln114His Uncertain significance Single submitter
- CEACAM3 p.Gln123His Uncertain significance Single submitter
- CEACAM3 p.Gln60His Uncertain significance Single submitter
- CEACAM3 p.Glu231Ala Uncertain significance Single submitter
- CEACAM3 p.Gly159Arg Uncertain significance Single submitter
- CEACAM3 p.Gly92Arg Uncertain significance Single submitter
- CEACAM3 p.Gly97Asp Uncertain significance Single submitter
- CEACAM3 p.His61Tyr Uncertain significance Single submitter
- CEACAM3 p.Ile240Met Uncertain significance Single submitter
- CEACAM3 p.Met41Thr Likely benign Single submitter
- CEACAM3 p.Pro198His Uncertain significance Single submitter
- CEACAM3 p.Pro42Ser Uncertain significance Single submitter
- CEACAM3 p.Pro91Leu Uncertain significance Single submitter
- CEACAM3 p.Pro91Ser Uncertain significance Single submitter
- CEACAM3 p.Thr225Ile Uncertain significance Single submitter
- CEACAM3 p.Thr90Ile Uncertain significance Single submitter
- CEACAM3 p.Tyr102His Uncertain significance Single submitter
- CEACAM3 p.Tyr68Cys Uncertain significance Single submitter
- CEACAM3 p.Val45Gly Uncertain significance Single submitter
All CEACAM3 variants
Benign 8
- p.Ala93Pro Multiple submitters
- p.Glu133Gly Multiple submitters ⚠
- p.Leu78Gln Multiple submitters
- p.Ser77Arg Multiple submitters
- p.Thr103= Multiple submitters
- p.Thr135= Multiple submitters
- p.Tyr95Asn Multiple submitters
- p.Val83Ala Multiple submitters
Likely benign 8
- p.Asn111= Multiple submitters
- p.Ala89Thr Single submitter
- p.Arg200His Single submitter
- p.Ile84Val Single submitter
- p.Met41Thr Single submitter ⚠
- p.Ser209Leu Single submitter
- p.Ser66Asn Single submitter
- p.Thr182Ala Single submitter
Uncertain significance 37
- p.Ala134Thr Single submitter ⚠
- p.Ala154Thr Single submitter ⚠
- p.Ala169Thr Single submitter ⚠
- p.Ala46Thr Single submitter ⚠
- p.Ala94Thr Single submitter ⚠
- p.Arg186Cys Single submitter ⚠
- p.Arg200Cys Single submitter ⚠
- p.Arg243Gln Single submitter ⚠
- p.Arg98Gln Single submitter ⚠
- p.Cys12Arg Single submitter ⚠
- p.Gln114His Single submitter ⚠
- p.Gln123His Single submitter ⚠
- p.Gln60His Single submitter ⚠
- p.Glu11Lys Single submitter ⚠
- p.Glu231Ala Single submitter ⚠
- p.Gly159Arg Single submitter ⚠
- p.Gly92Arg Single submitter ⚠
- p.Gly97Asp Single submitter ⚠
- p.His204Arg Single submitter ⚠
- p.His236Arg Single submitter ⚠
- p.His61Tyr Single submitter ⚠
- p.Ile240Met Single submitter ⚠
- p.Lys235Glu Single submitter ⚠
- p.Met41Ile Single submitter ⚠
- p.Phe208Val Single submitter ⚠
- p.Pro198His Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Pro91Leu Single submitter ⚠
- p.Pro91Ser Single submitter ⚠
- p.Ser205Gly Single submitter ⚠
- p.Thr225Ile Single submitter ⚠
- p.Thr225Ser Single submitter ⚠
- p.Thr90Ile Single submitter ⚠
- p.Tyr102His Single submitter ⚠
- p.Tyr68Cys Single submitter ⚠
- p.Val45Gly Single submitter ⚠
- p.Val80Ile Single submitter ⚠