CEACAM6 — 48 ClinVar variants
All ClinVar germline CEACAM6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Benign · 5 Likely benign · 41 Uncertain significance
Full CEACAM6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CEACAM6 p.Arg250His Uncertain significance Single submitter
- CEACAM6 p.Arg340Met Uncertain significance Single submitter
- CEACAM6 p.Arg62His Uncertain significance Single submitter
- CEACAM6 p.Asn195Asp Uncertain significance Single submitter
- CEACAM6 p.Glu143Asp Uncertain significance Single submitter
- CEACAM6 p.Glu17Val Uncertain significance Single submitter
- CEACAM6 p.Pro3Leu Uncertain significance Single submitter
- CEACAM6 p.Ser5Pro Uncertain significance Single submitter
- CEACAM6 p.Thr41Met Uncertain significance Single submitter
- CEACAM6 p.Trp179Arg Uncertain significance Single submitter
- CEACAM6 p.Val130Leu Uncertain significance Single submitter
- CEACAM6 p.Val13Ile Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- CEACAM6 p.Ala105Thr Uncertain significance Single submitter
- CEACAM6 p.Ala134Val Uncertain significance Single submitter
- CEACAM6 p.Arg225His Uncertain significance Single submitter
- CEACAM6 p.Arg250Cys Uncertain significance Single submitter
- CEACAM6 p.Asp209Asn Uncertain significance Single submitter
- CEACAM6 p.Gln192Leu Uncertain significance Single submitter
- CEACAM6 p.Gln268Leu Uncertain significance Single submitter
- CEACAM6 p.Gly136Arg Likely benign Single submitter
- CEACAM6 p.Gly295Arg Uncertain significance Single submitter
- CEACAM6 p.Gly332Ser Uncertain significance Single submitter
- CEACAM6 p.Gly92Val Uncertain significance Single submitter
- CEACAM6 p.Ile217Val Uncertain significance Single submitter
- CEACAM6 p.Ile38Thr Uncertain significance Single submitter
- CEACAM6 p.Leu284Phe Uncertain significance Single submitter
- CEACAM6 p.Leu52His Uncertain significance Single submitter
- CEACAM6 p.Lys16Glu Uncertain significance Single submitter
- CEACAM6 p.Lys69Glu Uncertain significance Single submitter
- CEACAM6 p.Pro103Thr Uncertain significance Single submitter
- CEACAM6 p.Pro142Leu Uncertain significance Single submitter
- CEACAM6 p.Pro186Leu Uncertain significance Single submitter
- CEACAM6 p.Ser106Phe Uncertain significance Single submitter
- CEACAM6 p.Thr175Asn Uncertain significance Single submitter
- CEACAM6 p.Thr230Ile Likely benign Single submitter
- CEACAM6 p.Thr32Ile Uncertain significance Single submitter
- CEACAM6 p.Thr90Asn Uncertain significance Single submitter
- CEACAM6 p.Val112Ile Uncertain significance Single submitter
- CEACAM6 p.Val124Ala Uncertain significance Single submitter
- CEACAM6 p.Val157Glu Uncertain significance Single submitter
- CEACAM6 p.Val163Met Uncertain significance Single submitter
- CEACAM6 p.Val205Ile Uncertain significance Single submitter
- CEACAM6 p.Val331Ile Uncertain significance Single submitter
All CEACAM6 variants
Benign 2
- p.Gly85Glu Multiple submitters
- p.His260= Multiple submitters
Likely benign 5
- p.Ala221Val Single submitter
- p.Gly136Arg Single submitter ⚠
- p.Pro103Ser Single submitter
- p.Thr230Ile Single submitter ⚠
- p.Thr314Met Single submitter
Uncertain significance 41
- p.Ala105Thr Single submitter ⚠
- p.Ala134Val Single submitter ⚠
- p.Arg225His Single submitter ⚠
- p.Arg250Cys Single submitter ⚠
- p.Arg250His Single submitter ⚠
- p.Arg340Met Single submitter ⚠
- p.Arg62His Single submitter ⚠
- p.Asn195Asp Single submitter ⚠
- p.Asp209Asn Single submitter ⚠
- p.Gln192Leu Single submitter ⚠
- p.Gln268Leu Single submitter ⚠
- p.Glu143Asp Single submitter ⚠
- p.Glu17Val Single submitter ⚠
- p.Gly295Arg Single submitter ⚠
- p.Gly332Ser Single submitter ⚠
- p.Gly92Val Single submitter ⚠
- p.Ile217Val Single submitter ⚠
- p.Ile38Thr Single submitter ⚠
- p.Leu284Phe Single submitter ⚠
- p.Leu52His Single submitter ⚠
- p.Lys16Glu Single submitter ⚠
- p.Lys69Glu Single submitter ⚠
- p.Pro103Thr Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro186Leu Single submitter ⚠
- p.Pro3Leu Single submitter ⚠
- p.Ser106Phe Single submitter ⚠
- p.Ser5Pro Single submitter ⚠
- p.Thr175Asn Single submitter ⚠
- p.Thr32Ile Single submitter ⚠
- p.Thr41Met Single submitter ⚠
- p.Thr90Asn Single submitter ⚠
- p.Trp179Arg Single submitter ⚠
- p.Val112Ile Single submitter ⚠
- p.Val124Ala Single submitter ⚠
- p.Val130Leu Single submitter ⚠
- p.Val13Ile Single submitter ⚠
- p.Val157Glu Single submitter ⚠
- p.Val163Met Single submitter ⚠
- p.Val205Ile Single submitter ⚠
- p.Val331Ile Single submitter ⚠