CEACAM8 — 61 ClinVar variants
All ClinVar germline CEACAM8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
5 Likely benign · 56 Uncertain significance
Full CEACAM8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CEACAM8 p.Pro186Leu Uncertain significance Multiple submitters
- CEACAM8 p.Ala162Val Uncertain significance Single submitter
- CEACAM8 p.Ala321Val Uncertain significance Single submitter
- CEACAM8 p.Arg345Lys Uncertain significance Single submitter
- CEACAM8 p.Arg345Met Uncertain significance Single submitter
- CEACAM8 p.Asn254Asp Uncertain significance Single submitter
- CEACAM8 p.Asp246Val Uncertain significance Single submitter
- CEACAM8 p.Gln183Leu Uncertain significance Single submitter
- CEACAM8 p.Gln279Arg Uncertain significance Single submitter
- CEACAM8 p.Glu214Lys Uncertain significance Single submitter
- CEACAM8 p.Glu71Lys Uncertain significance Single submitter
- CEACAM8 p.His250Arg Uncertain significance Single submitter
- CEACAM8 p.His250Asn Uncertain significance Single submitter
- CEACAM8 p.Ile340Thr Uncertain significance Single submitter
- CEACAM8 p.Met130Thr Uncertain significance Single submitter
- CEACAM8 p.Met315Ile Uncertain significance Single submitter
- CEACAM8 p.Pro30Leu Uncertain significance Single submitter
- CEACAM8 p.Thr144Ser Uncertain significance Single submitter
- CEACAM8 p.Thr171Ile Uncertain significance Single submitter
- CEACAM8 p.Thr247Ile Uncertain significance Single submitter
- CEACAM8 p.Tyr248Asp Uncertain significance Single submitter
- CEACAM8 p.Tyr248Cys Uncertain significance Single submitter
- CEACAM8 p.Val73Ala Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- CEACAM8 p.Ala261Glu Uncertain significance Single submitter
- CEACAM8 p.Arg10Lys Uncertain significance Single submitter
- CEACAM8 p.Arg308His Likely benign Single submitter
- CEACAM8 p.Arg63His Uncertain significance Single submitter
- CEACAM8 p.Arg78Gln Uncertain significance Single submitter
- CEACAM8 p.Arg78Gly Uncertain significance Single submitter
- CEACAM8 p.Arg98Gln Uncertain significance Single submitter
- CEACAM8 p.Asn104Lys Uncertain significance Single submitter
- CEACAM8 p.Asn293Ile Uncertain significance Single submitter
- CEACAM8 p.Asn309Lys Uncertain significance Single submitter
- CEACAM8 p.Asn57Ser Uncertain significance Single submitter
- CEACAM8 p.Asn76His Uncertain significance Single submitter
- CEACAM8 p.Asn86Ile Uncertain significance Single submitter
- CEACAM8 p.Asp161His Uncertain significance Single submitter
- CEACAM8 p.Gln123Lys Uncertain significance Single submitter
- CEACAM8 p.Gln183Pro Uncertain significance Single submitter
- CEACAM8 p.Glu170Gln Uncertain significance Single submitter
- CEACAM8 p.Glu47Asp Uncertain significance Single submitter
- CEACAM8 p.Gly211Glu Uncertain significance Single submitter
- CEACAM8 p.Gly252Arg Uncertain significance Single submitter
- CEACAM8 p.Gly307Val Uncertain significance Single submitter
- CEACAM8 p.Leu185Val Uncertain significance Single submitter
- CEACAM8 p.Leu20Pro Uncertain significance Single submitter
- CEACAM8 p.Pro142Leu Uncertain significance Single submitter
- CEACAM8 p.Pro220Arg Uncertain significance Single submitter
- CEACAM8 p.Pro220Ser Uncertain significance Single submitter
- CEACAM8 p.Ser139Gly Uncertain significance Single submitter
- CEACAM8 p.Ser150Pro Uncertain significance Single submitter
- CEACAM8 p.Thr230Ile Uncertain significance Single submitter
- CEACAM8 p.Thr290Ala Uncertain significance Single submitter
- CEACAM8 p.Thr306Ser Uncertain significance Single submitter
- CEACAM8 p.Thr72Arg Uncertain significance Single submitter
- CEACAM8 p.Tyr297Cys Uncertain significance Single submitter
- CEACAM8 p.Val140Ile Uncertain significance Single submitter
- CEACAM8 p.Val342Ile Likely benign Single submitter
All CEACAM8 variants
Likely benign 5
- p.Ala221Val Single submitter
- p.Arg308His Single submitter ⚠
- p.Asn97Ser Single submitter
- p.Ser131Asn Single submitter
- p.Val342Ile Single submitter ⚠
Uncertain significance 56
- p.Pro186Leu Multiple submitters ⚠
- p.Ala162Val Single submitter ⚠
- p.Ala261Glu Single submitter ⚠
- p.Ala321Val Single submitter ⚠
- p.Arg10Lys Single submitter ⚠
- p.Arg345Lys Single submitter ⚠
- p.Arg345Met Single submitter ⚠
- p.Arg63His Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Arg78Gly Single submitter ⚠
- p.Arg98Gln Single submitter ⚠
- p.Asn104Lys Single submitter ⚠
- p.Asn254Asp Single submitter ⚠
- p.Asn293Ile Single submitter ⚠
- p.Asn309Lys Single submitter ⚠
- p.Asn57Ser Single submitter ⚠
- p.Asn76His Single submitter ⚠
- p.Asn86Ile Single submitter ⚠
- p.Asp161His Single submitter ⚠
- p.Asp246Val Single submitter ⚠
- p.Gln123Lys Single submitter ⚠
- p.Gln183Leu Single submitter ⚠
- p.Gln183Pro Single submitter ⚠
- p.Gln279Arg Single submitter ⚠
- p.Glu170Gln Single submitter ⚠
- p.Glu214Lys Single submitter ⚠
- p.Glu47Asp Single submitter ⚠
- p.Glu71Lys Single submitter ⚠
- p.Gly211Glu Single submitter ⚠
- p.Gly252Arg Single submitter ⚠
- p.Gly307Val Single submitter ⚠
- p.His250Arg Single submitter ⚠
- p.His250Asn Single submitter ⚠
- p.Ile340Thr Single submitter ⚠
- p.Leu185Val Single submitter ⚠
- p.Leu20Pro Single submitter ⚠
- p.Met130Thr Single submitter ⚠
- p.Met315Ile Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro220Arg Single submitter ⚠
- p.Pro220Ser Single submitter ⚠
- p.Pro30Leu Single submitter ⚠
- p.Ser139Gly Single submitter ⚠
- p.Ser150Pro Single submitter ⚠
- p.Thr144Ser Single submitter ⚠
- p.Thr171Ile Single submitter ⚠
- p.Thr230Ile Single submitter ⚠
- p.Thr247Ile Single submitter ⚠
- p.Thr290Ala Single submitter ⚠
- p.Thr306Ser Single submitter ⚠
- p.Thr72Arg Single submitter ⚠
- p.Tyr248Asp Single submitter ⚠
- p.Tyr248Cys Single submitter ⚠
- p.Tyr297Cys Single submitter ⚠
- p.Val140Ile Single submitter ⚠
- p.Val73Ala Single submitter ⚠