CELF1 — 35 ClinVar variants
All ClinVar germline CELF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
1 Benign · 34 Uncertain significance
Full CELF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CELF1 p.Ala99Val Uncertain significance Single submitter
- CELF1 p.Arg96His Uncertain significance Single submitter
- CELF1 p.Arg96Leu Uncertain significance Single submitter
- CELF1 p.Gln289His Uncertain significance Single submitter
- CELF1 p.Gln389Arg Uncertain significance Single submitter
- CELF1 p.Glu64Lys Uncertain significance Single submitter
- CELF1 p.Gly369Asp Uncertain significance Single submitter
- CELF1 p.Leu311Pro Uncertain significance Single submitter
- CELF1 p.Lys97Glu Uncertain significance Single submitter
- CELF1 p.Met280Val Uncertain significance Single submitter
- CELF1 p.Met448Ile Uncertain significance Single submitter
- CELF1 p.Met490Val Uncertain significance Single submitter
- CELF1 p.Pro339Ala Uncertain significance Single submitter
- CELF1 p.Pro82Leu Uncertain significance Single submitter
- CELF1 p.Ser306Gly Uncertain significance Single submitter
- CELF1 p.Thr183Ala Uncertain significance Single submitter
- CELF1 p.Tyr391Cys Uncertain significance Single submitter
- CELF1 p.Val153Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CELF1 p.Ala237Thr Uncertain significance Single submitter
- CELF1 p.Ala401Val Uncertain significance Single submitter
- CELF1 p.Arg152Gln Uncertain significance Single submitter
- CELF1 p.Arg506His Uncertain significance Single submitter
- CELF1 p.Arg60Gln Uncertain significance Single submitter
- CELF1 p.Asn357Ser Uncertain significance Single submitter
- CELF1 p.Asn479Ser Uncertain significance Single submitter
- CELF1 p.Asp171Asn Uncertain significance Single submitter
- CELF1 p.Glu385Gly Uncertain significance Single submitter
- CELF1 p.His34Pro Uncertain significance Single submitter
- CELF1 p.Ile119Met Uncertain significance Single submitter
- CELF1 p.Ile119Val Uncertain significance Single submitter
- CELF1 p.Leu356Phe Uncertain significance Single submitter
- CELF1 p.Leu371Val Uncertain significance Single submitter
- CELF1 p.Ser79Arg Uncertain significance Single submitter
- CELF1 p.Val74Ile Uncertain significance Single submitter
All CELF1 variants
Benign 1
- p.Ser507= Multiple submitters
Uncertain significance 34
- p.Ala237Thr Single submitter ⚠
- p.Ala401Val Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg152Gln Single submitter ⚠
- p.Arg506His Single submitter ⚠
- p.Arg60Gln Single submitter ⚠
- p.Arg96His Single submitter ⚠
- p.Arg96Leu Single submitter ⚠
- p.Asn357Ser Single submitter ⚠
- p.Asn479Ser Single submitter ⚠
- p.Asp171Asn Single submitter ⚠
- p.Gln289His Single submitter ⚠
- p.Gln389Arg Single submitter ⚠
- p.Glu385Gly Single submitter ⚠
- p.Glu64Lys Single submitter ⚠
- p.Gly369Asp Single submitter ⚠
- p.His34Pro Single submitter ⚠
- p.Ile119Met Single submitter ⚠
- p.Ile119Val Single submitter ⚠
- p.Leu311Pro Single submitter ⚠
- p.Leu356Phe Single submitter ⚠
- p.Leu371Val Single submitter ⚠
- p.Lys97Glu Single submitter ⚠
- p.Met280Val Single submitter ⚠
- p.Met448Ile Single submitter ⚠
- p.Met490Val Single submitter ⚠
- p.Pro339Ala Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Ser306Gly Single submitter ⚠
- p.Ser79Arg Single submitter ⚠
- p.Thr183Ala Single submitter ⚠
- p.Tyr391Cys Single submitter ⚠
- p.Val153Ile Single submitter ⚠
- p.Val74Ile Single submitter ⚠