CELF5 — 31 ClinVar variants
All ClinVar germline CELF5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
2 Likely benign · 29 Uncertain significance
Full CELF5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CELF5 p.Ala309Thr Uncertain significance Single submitter
- CELF5 p.Arg218Leu Uncertain significance Single submitter
- CELF5 p.Gln12Arg Uncertain significance Single submitter
- CELF5 p.Gln13Leu Uncertain significance Single submitter
- CELF5 p.Glu354Gln Uncertain significance Single submitter
- CELF5 p.Gly269Ser Uncertain significance Single submitter
- CELF5 p.Gly33Ala Uncertain significance Single submitter
- CELF5 p.Gly362Arg Uncertain significance Single submitter
- CELF5 p.His331Arg Uncertain significance Single submitter
- CELF5 p.Ile71Met Uncertain significance Single submitter
- CELF5 p.Leu16Pro Uncertain significance Single submitter
- CELF5 p.Met369Leu Uncertain significance Single submitter
- CELF5 p.Pro302Ser Uncertain significance Single submitter
- CELF5 p.Pro31Ser Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CELF5 p.Gln364Pro Uncertain significance Multiple submitters
- CELF5 p.Ala373Val Uncertain significance Single submitter
- CELF5 p.Arg117Trp Uncertain significance Single submitter
- CELF5 p.Arg129His Uncertain significance Single submitter
- CELF5 p.Gln155Leu Uncertain significance Single submitter
- CELF5 p.Gly38Cys Uncertain significance Single submitter
- CELF5 p.Met419Thr Uncertain significance Single submitter
- CELF5 p.Met433Thr Uncertain significance Single submitter
- CELF5 p.Pro451Leu Uncertain significance Single submitter
- CELF5 p.Pro484Arg Uncertain significance Single submitter
- CELF5 p.Ser349Asn Uncertain significance Single submitter
- CELF5 p.Thr219Lys Uncertain significance Single submitter
- CELF5 p.Thr414Met Uncertain significance Single submitter
- CELF5 p.Val314Met Uncertain significance Single submitter
All CELF5 variants
Uncertain significance 29
- p.Gln364Pro Multiple submitters ⚠
- p.Ala309Thr Single submitter ⚠
- p.Ala373Val Single submitter ⚠
- p.Arg117Trp Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg218Leu Single submitter ⚠
- p.Arg222fs Single submitter
- p.Gln12Arg Single submitter ⚠
- p.Gln13Leu Single submitter ⚠
- p.Gln155Leu Single submitter ⚠
- p.Glu354Gln Single submitter ⚠
- p.Gly269Ser Single submitter ⚠
- p.Gly33Ala Single submitter ⚠
- p.Gly362Arg Single submitter ⚠
- p.Gly38Cys Single submitter ⚠
- p.His331Arg Single submitter ⚠
- p.Ile71Met Single submitter ⚠
- p.Leu16Pro Single submitter ⚠
- p.Met369Leu Single submitter ⚠
- p.Met419Thr Single submitter ⚠
- p.Met433Thr Single submitter ⚠
- p.Pro302Ser Single submitter ⚠
- p.Pro31Ser Single submitter ⚠
- p.Pro451Leu Single submitter ⚠
- p.Pro484Arg Single submitter ⚠
- p.Ser349Asn Single submitter ⚠
- p.Thr219Lys Single submitter ⚠
- p.Thr414Met Single submitter ⚠
- p.Val314Met Single submitter ⚠