CENPA — 12 ClinVar variants
All ClinVar germline CENPA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Likely benign · 11 Uncertain significance
Full CENPA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPA p.Arg80His Uncertain significance Single submitter
- CENPA p.Gly25Arg Uncertain significance Single submitter
- CENPA p.Phe101Ser Uncertain significance Single submitter
- CENPA p.Pro18Arg Uncertain significance Single submitter
- CENPA p.Pro26Ala Uncertain significance Single submitter
- CENPA p.Thr21Pro Uncertain significance Single submitter
- CENPA p.Thr23Pro Uncertain significance Single submitter
- CENPA p.Val76Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CENPA variants
Likely benign 1
- p.Ala35Thr Single submitter
Uncertain significance 11
- p.Arg42Trp Single submitter ⚠
- p.Arg43Trp Single submitter ⚠
- p.Arg52Gln Single submitter ⚠
- p.Arg80His Single submitter ⚠
- p.Gly25Arg Single submitter ⚠
- p.Phe101Ser Single submitter ⚠
- p.Pro18Arg Single submitter ⚠
- p.Pro26Ala Single submitter ⚠
- p.Thr21Pro Single submitter ⚠
- p.Thr23Pro Single submitter ⚠
- p.Val76Ile Single submitter ⚠