Sugi Variant

Sugi Variant/CENPF

CENPF — 919 ClinVar variants

All ClinVar germline CENPF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 506 flagged for review →

26 Pathogenic · 3 Pathogenic/Likely pathogenic · 35 Likely pathogenic · 30 Conflicting · 96 Benign · 32 Benign/Likely benign · 170 Likely benign · 527 Uncertain significance

Full CENPF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 506

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 27

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 463

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 463

Predictors split 16

The independent predictors disagree with each other — read with care.

All CENPF variants

Pathogenic 26

Pathogenic/Likely pathogenic 3

Likely pathogenic 35

Conflicting classifications of pathogenicity 30

Benign 96

Benign/Likely benign 32

Likely benign 170

Uncertain significance 527

Showing the top 300 by review status; the full set is in the sitemap.