CENPH — 38 ClinVar variants
All ClinVar germline CENPH variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
3 Likely benign · 35 Uncertain significance
Full CENPH gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPH p.Ala22Gly Uncertain significance Single submitter
- CENPH p.Ala33Val Uncertain significance Single submitter
- CENPH p.Ala48Thr Uncertain significance Single submitter
- CENPH p.Asp38Glu Uncertain significance Single submitter
- CENPH p.Asp84Ala Uncertain significance Single submitter
- CENPH p.Glu12Ala Uncertain significance Single submitter
- CENPH p.Glu79Lys Uncertain significance Single submitter
- CENPH p.Gly222Arg Uncertain significance Single submitter
- CENPH p.Ile140Val Uncertain significance Single submitter
- CENPH p.Ile184Met Uncertain significance Single submitter
- CENPH p.Ile197Met Uncertain significance Single submitter
- CENPH p.Ile206Thr Uncertain significance Single submitter
- CENPH p.Ile236Val Uncertain significance Single submitter
- CENPH p.Ile78Asn Uncertain significance Single submitter
- CENPH p.Leu172Pro Uncertain significance Single submitter
- CENPH p.Leu44Pro Uncertain significance Single submitter
- CENPH p.Lys159Arg Uncertain significance Single submitter
- CENPH p.Lys179Glu Uncertain significance Single submitter
- CENPH p.Met141Thr Uncertain significance Single submitter
- CENPH p.Met246Ile Uncertain significance Single submitter
- CENPH p.Met60Ile Uncertain significance Single submitter
- CENPH p.Met7Arg Uncertain significance Single submitter
- CENPH p.Pro5Leu Uncertain significance Single submitter
- CENPH p.Pro69Ser Uncertain significance Single submitter
- CENPH p.Ser188Thr Uncertain significance Single submitter
- CENPH p.Ser223Arg Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CENPH p.Arg21Trp Uncertain significance Single submitter
- CENPH p.Arg39His Uncertain significance Single submitter
- CENPH p.Arg47Thr Uncertain significance Single submitter
- CENPH p.Asp128Gly Uncertain significance Single submitter
- CENPH p.Glu3Lys Likely benign Single submitter
- CENPH p.Ile82Ser Uncertain significance Single submitter
- CENPH p.Leu162Phe Uncertain significance Single submitter
- CENPH p.Lys153Thr Uncertain significance Single submitter
- CENPH p.Lys81Ile Uncertain significance Single submitter
-
CENPH p.Ile212Thr
Uncertain significance
No assertion criteria
Recurrent spontaneous abortion
All CENPH variants
Likely benign 3
- p.Arg199Gln Single submitter
- p.Glu3Lys Single submitter ⚠
- p.Val94Ile Single submitter
Uncertain significance 35
- p.Ala22Gly Single submitter ⚠
- p.Ala33Val Single submitter ⚠
- p.Ala48Thr Single submitter ⚠
- p.Arg21Trp Single submitter ⚠
- p.Arg39His Single submitter ⚠
- p.Arg47Thr Single submitter ⚠
- p.Asp128Gly Single submitter ⚠
- p.Asp38Glu Single submitter ⚠
- p.Asp84Ala Single submitter ⚠
- p.Glu12Ala Single submitter ⚠
- p.Glu79Lys Single submitter ⚠
- p.Gly222Arg Single submitter ⚠
- p.Ile140Val Single submitter ⚠
- p.Ile184Met Single submitter ⚠
- p.Ile197Met Single submitter ⚠
- p.Ile206Thr Single submitter ⚠
- p.Ile236Val Single submitter ⚠
- p.Ile78Asn Single submitter ⚠
- p.Ile82Ser Single submitter ⚠
- p.Leu162Phe Single submitter ⚠
- p.Leu172Pro Single submitter ⚠
- p.Leu44Pro Single submitter ⚠
- p.Lys153Thr Single submitter ⚠
- p.Lys159Arg Single submitter ⚠
- p.Lys179Glu Single submitter ⚠
- p.Lys81Ile Single submitter ⚠
- p.Met141Thr Single submitter ⚠
- p.Met246Ile Single submitter ⚠
- p.Met60Ile Single submitter ⚠
- p.Met7Arg Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Pro69Ser Single submitter ⚠
- p.Ser188Thr Single submitter ⚠
- p.Ser223Arg Single submitter ⚠
- p.Ile212Thr No assertion criteria Recurrent spontaneous abortion ⚠