CENPI — 68 ClinVar variants
All ClinVar germline CENPI variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
2 Benign · 9 Likely benign · 57 Uncertain significance
Full CENPI gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPI p.Ala147Gly Uncertain significance Single submitter
- CENPI p.Ala674Asp Uncertain significance Single submitter
- CENPI p.Ala692Thr Uncertain significance Single submitter
- CENPI p.Arg177Cys Uncertain significance Single submitter
- CENPI p.Arg298His Uncertain significance Single submitter
- CENPI p.Arg549His Uncertain significance Single submitter
- CENPI p.Asn553Lys Uncertain significance Single submitter
- CENPI p.Asn753Asp Uncertain significance Single submitter
- CENPI p.Asp176Val Uncertain significance Single submitter
- CENPI p.Asp195Ala Uncertain significance Single submitter
- CENPI p.Asp59Gly Uncertain significance Single submitter
- CENPI p.Cys604Gly Uncertain significance Single submitter
- CENPI p.Gln343Lys Uncertain significance Single submitter
- CENPI p.Glu286Gly Uncertain significance Single submitter
- CENPI p.Glu55Gln Uncertain significance Single submitter
- CENPI p.Gly122Ala Uncertain significance Single submitter
- CENPI p.Gly411Ala Uncertain significance Single submitter
- CENPI p.Gly672Ala Uncertain significance Single submitter
- CENPI p.His374Tyr Uncertain significance Single submitter
- CENPI p.Ile115Thr Uncertain significance Single submitter
- CENPI p.Ile134Met Uncertain significance Single submitter
- CENPI p.Leu313Pro Uncertain significance Single submitter
- CENPI p.Leu341Val Uncertain significance Single submitter
- CENPI p.Leu386Gln Uncertain significance Single submitter
- CENPI p.Lys215Arg Uncertain significance Single submitter
- CENPI p.Met133Val Uncertain significance Single submitter
- CENPI p.Met530Val Uncertain significance Single submitter
- CENPI p.Met548Leu Uncertain significance Single submitter
- CENPI p.Met647Ile Uncertain significance Single submitter
- CENPI p.Phe455Leu Uncertain significance Single submitter
- CENPI p.Pro283Leu Uncertain significance Single submitter
- CENPI p.Ser20Asn Uncertain significance Single submitter
- CENPI p.Ser590Ala Uncertain significance Single submitter
- CENPI p.Ser709Asn Uncertain significance Single submitter
- CENPI p.Thr653Met Uncertain significance Single submitter
- CENPI p.Trp100Arg Uncertain significance Single submitter
- CENPI p.Tyr572His Uncertain significance Single submitter
- CENPI p.Val623Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CENPI p.Arg218His Uncertain significance Single submitter
- CENPI p.Asn97Ile Uncertain significance Single submitter
- CENPI p.Asp194His Uncertain significance Single submitter
- CENPI p.Asp664Gly Uncertain significance Single submitter
- CENPI p.Asp85Tyr Uncertain significance Single submitter
- CENPI p.Gln454Arg Uncertain significance Single submitter
- CENPI p.Gly119Asp Uncertain significance Single submitter
- CENPI p.Ile175Leu Uncertain significance Single submitter
- CENPI p.Ile422Ser Uncertain significance Single submitter
- CENPI p.Phe174Ile Uncertain significance Single submitter
- CENPI p.Phe724Leu Uncertain significance Single submitter
- CENPI p.Ser690Asn Uncertain significance Single submitter
- CENPI p.Ser709Ile Uncertain significance Single submitter
- CENPI p.Tyr375Cys Uncertain significance Single submitter
- CENPI p.Tyr589Cys Uncertain significance Single submitter
- CENPI p.Val98Met Uncertain significance Single submitter
All CENPI variants
Benign 2
- p.Val10Ile Multiple submitters
- p.Val276Met Multiple submitters
Likely benign 9
- p.Arg166His Single submitter premature menopause
- p.Arg611His Single submitter
- p.Asn369Ser Single submitter
- p.Gly411Glu Single submitter
- p.Leu439= Single submitter
- p.Ser149= Single submitter
- p.Ser361= Single submitter
- p.Thr271Met Single submitter
- p.Asn681Ser No assertion criteria
Uncertain significance 57
- c.1195+6A>G Single submitter
- c.687+8C>T Single submitter
- p.Ala147Gly Single submitter ⚠
- p.Ala674Asp Single submitter ⚠
- p.Ala692Thr Single submitter ⚠
- p.Arg177Cys Single submitter ⚠
- p.Arg218His Single submitter ⚠
- p.Arg298His Single submitter ⚠
- p.Arg549His Single submitter ⚠
- p.Asn553Lys Single submitter ⚠
- p.Asn753Asp Single submitter ⚠
- p.Asn97Ile Single submitter ⚠
- p.Asp176Val Single submitter ⚠
- p.Asp194His Single submitter ⚠
- p.Asp195Ala Single submitter ⚠
- p.Asp59Gly Single submitter ⚠
- p.Asp664Gly Single submitter ⚠
- p.Asp85Tyr Single submitter ⚠
- p.Cys604Gly Single submitter ⚠
- p.Gln343Lys Single submitter ⚠
- p.Gln454Arg Single submitter ⚠
- p.Glu286Gly Single submitter ⚠
- p.Glu55Gln Single submitter ⚠
- p.Gly119Asp Single submitter ⚠
- p.Gly122Ala Single submitter ⚠
- p.Gly411Ala Single submitter ⚠
- p.Gly672Ala Single submitter ⚠
- p.His374Tyr Single submitter ⚠
- p.Ile115Thr Single submitter ⚠
- p.Ile134Met Single submitter ⚠
- p.Ile175Leu Single submitter ⚠
- p.Ile422Ser Single submitter ⚠
- p.Leu313Pro Single submitter ⚠
- p.Leu341Val Single submitter ⚠
- p.Leu386Gln Single submitter ⚠
- p.Lys131= Single submitter
- p.Lys215Arg Single submitter ⚠
- p.Met133Val Single submitter ⚠
- p.Met530Val Single submitter ⚠
- p.Met548Leu Single submitter ⚠
- p.Met647Ile Single submitter ⚠
- p.Phe174Ile Single submitter ⚠
- p.Phe455Leu Single submitter ⚠
- p.Phe724Leu Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Ser20Asn Single submitter ⚠
- p.Ser590Ala Single submitter ⚠
- p.Ser690Asn Single submitter ⚠
- p.Ser709Asn Single submitter ⚠
- p.Ser709Ile Single submitter ⚠
- p.Thr653Met Single submitter ⚠
- p.Trp100Arg Single submitter ⚠
- p.Tyr375Cys Single submitter ⚠
- p.Tyr572His Single submitter ⚠
- p.Tyr589Cys Single submitter ⚠
- p.Val623Ile Single submitter ⚠
- p.Val98Met Single submitter ⚠