CENPK — 33 ClinVar variants
All ClinVar germline CENPK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
2 Likely benign · 31 Uncertain significance
Full CENPK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPK p.Asn221Ser Uncertain significance Single submitter
- CENPK p.Asn54Asp Uncertain significance Single submitter
- CENPK p.Asp13Gly Uncertain significance Single submitter
- CENPK p.Gln3Glu Uncertain significance Single submitter
- CENPK p.Ile220Val Uncertain significance Single submitter
- CENPK p.Leu6Arg Uncertain significance Single submitter
- CENPK p.Lys114Met Uncertain significance Single submitter
- CENPK p.Lys76Thr Uncertain significance Single submitter
- CENPK p.Met166Val Uncertain significance Single submitter
- CENPK p.Pro79Ser Uncertain significance Single submitter
- CENPK p.Pro8Leu Uncertain significance Single submitter
- CENPK p.Ser194Thr Uncertain significance Single submitter
- CENPK p.Ser72Thr Uncertain significance Single submitter
- CENPK p.Thr11Ile Uncertain significance Single submitter
- CENPK p.Thr260Ser Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CENPK p.Arg127Trp Uncertain significance Single submitter
- CENPK p.Arg222Gly Uncertain significance Single submitter
- CENPK p.Arg261Gln Uncertain significance Single submitter
- CENPK p.Asp258Tyr Uncertain significance Single submitter
- CENPK p.Asp34Tyr Uncertain significance Single submitter
- CENPK p.Gln269Pro Uncertain significance Single submitter
- CENPK p.Glu120Gly Uncertain significance Single submitter
- CENPK p.His228Arg Uncertain significance Single submitter
- CENPK p.Ile234Met Uncertain significance Single submitter
- CENPK p.Leu44Phe Uncertain significance Single submitter
- CENPK p.Leu57Gln Uncertain significance Single submitter
- CENPK p.Leu71Phe Uncertain significance Single submitter
- CENPK p.Lys198Glu Uncertain significance Single submitter
- CENPK p.Met35Thr Uncertain significance Single submitter
- CENPK p.Ser206Tyr Uncertain significance Single submitter
- CENPK p.Trp32Cys Uncertain significance Single submitter
All CENPK variants
Likely benign 2
- p.Arg127Gln Single submitter
- p.Glu27Lys Single submitter
Uncertain significance 31
- p.Arg127Trp Single submitter ⚠
- p.Arg222Gly Single submitter ⚠
- p.Arg261Gln Single submitter ⚠
- p.Asn221Ser Single submitter ⚠
- p.Asn54Asp Single submitter ⚠
- p.Asp13Gly Single submitter ⚠
- p.Asp258Tyr Single submitter ⚠
- p.Asp34Tyr Single submitter ⚠
- p.Gln269Pro Single submitter ⚠
- p.Gln3Glu Single submitter ⚠
- p.Glu120Gly Single submitter ⚠
- p.His228Arg Single submitter ⚠
- p.Ile220Val Single submitter ⚠
- p.Ile234Met Single submitter ⚠
- p.Leu44Phe Single submitter ⚠
- p.Leu57Gln Single submitter ⚠
- p.Leu6Arg Single submitter ⚠
- p.Leu71Phe Single submitter ⚠
- p.Lys114Met Single submitter ⚠
- p.Lys198Glu Single submitter ⚠
- p.Lys76Thr Single submitter ⚠
- p.Met166Val Single submitter ⚠
- p.Met35Thr Single submitter ⚠
- p.Pro79Ser Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser194Thr Single submitter ⚠
- p.Ser206Tyr Single submitter ⚠
- p.Ser72Thr Single submitter ⚠
- p.Thr11Ile Single submitter ⚠
- p.Thr260Ser Single submitter ⚠
- p.Trp32Cys Single submitter ⚠