CENPL — 46 ClinVar variants
All ClinVar germline CENPL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
6 Likely benign · 40 Uncertain significance
Full CENPL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPL p.Ala108Val Uncertain significance Single submitter
- CENPL p.Ala227Thr Uncertain significance Single submitter
- CENPL p.Ala255Thr Uncertain significance Single submitter
- CENPL p.Arg16Ile Uncertain significance Single submitter
- CENPL p.Arg30Pro Uncertain significance Single submitter
- CENPL p.Asn187Lys Uncertain significance Single submitter
- CENPL p.Asn87Ser Uncertain significance Single submitter
- CENPL p.Asp281Asn Uncertain significance Single submitter
- CENPL p.Asp58Gly Uncertain significance Single submitter
- CENPL p.Cys245Arg Uncertain significance Single submitter
- CENPL p.Cys52Arg Uncertain significance Single submitter
- CENPL p.Gln54Pro Uncertain significance Single submitter
- CENPL p.Gln62Lys Uncertain significance Single submitter
- CENPL p.Glu57Lys Uncertain significance Single submitter
- CENPL p.Ile141Leu Uncertain significance Single submitter
- CENPL p.Ile256Val Uncertain significance Single submitter
- CENPL p.Ile99Val Uncertain significance Single submitter
- CENPL p.Leu328Val Uncertain significance Single submitter
- CENPL p.Lys118Arg Uncertain significance Single submitter
- CENPL p.Lys202Glu Uncertain significance Single submitter
- CENPL p.Lys70Arg Uncertain significance Single submitter
- CENPL p.Met127Thr Uncertain significance Single submitter
- CENPL p.Met224Leu Uncertain significance Single submitter
- CENPL p.Pro17Arg Uncertain significance Single submitter
- CENPL p.Pro50Leu Uncertain significance Single submitter
- CENPL p.Pro79Ser Uncertain significance Single submitter
- CENPL p.Ser242Thr Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CENPL p.Ala212Gly Uncertain significance Single submitter
- CENPL p.Arg30Gln Uncertain significance Single submitter
- CENPL p.Asp133Asn Uncertain significance Single submitter
- CENPL p.Glu135Gln Uncertain significance Single submitter
- CENPL p.Leu211Val Uncertain significance Single submitter
- CENPL p.Leu67Phe Uncertain significance Single submitter
- CENPL p.Lys202Thr Uncertain significance Single submitter
- CENPL p.Pro134Leu Uncertain significance Single submitter
- CENPL p.Thr25Ile Uncertain significance Single submitter
- CENPL p.Val142Ala Uncertain significance Single submitter
- CENPL p.Val156Met Uncertain significance Single submitter
- CENPL p.Val174Ala Uncertain significance Single submitter
- CENPL p.Val243Ala Uncertain significance Single submitter
All CENPL variants
Likely benign 6
- p.Ala212Thr Single submitter
- p.Ala6Val Single submitter
- p.Glu18Lys Single submitter
- p.Ile340Val Single submitter
- p.Val165Ile Single submitter
- p.Val34Ile Single submitter
Uncertain significance 40
- p.Ala108Val Single submitter ⚠
- p.Ala212Gly Single submitter ⚠
- p.Ala227Thr Single submitter ⚠
- p.Ala255Thr Single submitter ⚠
- p.Arg16Ile Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg30Pro Single submitter ⚠
- p.Asn187Lys Single submitter ⚠
- p.Asn87Ser Single submitter ⚠
- p.Asp133Asn Single submitter ⚠
- p.Asp281Asn Single submitter ⚠
- p.Asp58Gly Single submitter ⚠
- p.Cys245Arg Single submitter ⚠
- p.Cys52Arg Single submitter ⚠
- p.Gln54Pro Single submitter ⚠
- p.Gln62Lys Single submitter ⚠
- p.Glu135Gln Single submitter ⚠
- p.Glu57Lys Single submitter ⚠
- p.Ile141Leu Single submitter ⚠
- p.Ile256Val Single submitter ⚠
- p.Ile99Val Single submitter ⚠
- p.Leu211Val Single submitter ⚠
- p.Leu328Val Single submitter ⚠
- p.Leu67Phe Single submitter ⚠
- p.Lys118Arg Single submitter ⚠
- p.Lys202Glu Single submitter ⚠
- p.Lys202Thr Single submitter ⚠
- p.Lys70Arg Single submitter ⚠
- p.Met127Thr Single submitter ⚠
- p.Met224Leu Single submitter ⚠
- p.Pro134Leu Single submitter ⚠
- p.Pro17Arg Single submitter ⚠
- p.Pro50Leu Single submitter ⚠
- p.Pro79Ser Single submitter ⚠
- p.Ser242Thr Single submitter ⚠
- p.Thr25Ile Single submitter ⚠
- p.Val142Ala Single submitter ⚠
- p.Val156Met Single submitter ⚠
- p.Val174Ala Single submitter ⚠
- p.Val243Ala Single submitter ⚠