CENPN — 58 ClinVar variants
All ClinVar germline CENPN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
4 Likely benign · 54 Uncertain significance
Full CENPN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPN p.Ala312Val Uncertain significance Single submitter
- CENPN p.Ala61Gly Uncertain significance Single submitter
- CENPN p.Arg292Gln Uncertain significance Single submitter
- CENPN p.Arg42Gln Uncertain significance Single submitter
- CENPN p.Arg60Leu Uncertain significance Single submitter
- CENPN p.Asn280Ser Uncertain significance Single submitter
- CENPN p.Asn34Asp Uncertain significance Single submitter
- CENPN p.Asp199Glu Uncertain significance Single submitter
- CENPN p.Asp2Glu Uncertain significance Single submitter
- CENPN p.Gln223Lys Uncertain significance Single submitter
- CENPN p.Gln253Glu Uncertain significance Single submitter
- CENPN p.Gln261Glu Uncertain significance Single submitter
- CENPN p.Gln268Arg Uncertain significance Single submitter
- CENPN p.Gln37His Uncertain significance Single submitter
- CENPN p.Gln75His Uncertain significance Single submitter
- CENPN p.Glu46Gln Uncertain significance Single submitter
- CENPN p.Gly91Arg Uncertain significance Single submitter
- CENPN p.His239Pro Uncertain significance Single submitter
- CENPN p.His51Gln Uncertain significance Single submitter
- CENPN p.His79Tyr Uncertain significance Single submitter
- CENPN p.Ile111Val Uncertain significance Single submitter
- CENPN p.Ile204Val Uncertain significance Single submitter
- CENPN p.Leu264Val Uncertain significance Single submitter
- CENPN p.Lys184Gln Uncertain significance Single submitter
- CENPN p.Lys207Gln Uncertain significance Single submitter
- CENPN p.Lys245Glu Uncertain significance Single submitter
- CENPN p.Lys307Arg Uncertain significance Single submitter
- CENPN p.Met101Arg Uncertain significance Single submitter
- CENPN p.Met167Leu Uncertain significance Single submitter
- CENPN p.Met18Ile Uncertain significance Single submitter
- CENPN p.Phe30Val Uncertain significance Single submitter
- CENPN p.Pro173Leu Uncertain significance Single submitter
- CENPN p.Pro221Ser Uncertain significance Single submitter
- CENPN p.Pro260Ala Uncertain significance Single submitter
- CENPN p.Thr120Lys Uncertain significance Single submitter
- CENPN p.Thr163Met Uncertain significance Single submitter
- CENPN p.Thr212Ala Uncertain significance Single submitter
- CENPN p.Thr219Met Uncertain significance Single submitter
- CENPN p.Thr22Lys Uncertain significance Single submitter
- CENPN p.Thr273Met Uncertain significance Single submitter
- CENPN p.Thr38Ser Uncertain significance Single submitter
- CENPN p.Tyr141Phe Uncertain significance Single submitter
- CENPN p.Tyr154His Uncertain significance Single submitter
- CENPN p.Tyr197His Uncertain significance Single submitter
- CENPN p.Val152Met Uncertain significance Single submitter
- CENPN p.Val205Ala Uncertain significance Single submitter
- CENPN p.Val5Phe Uncertain significance Single submitter
- CENPN p.Val85Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CENPN p.Cys293Tyr Uncertain significance Single submitter
- CENPN p.Ile295Thr Uncertain significance Single submitter
- CENPN p.Ile9Thr Uncertain significance Single submitter
- CENPN p.Leu271Phe Uncertain significance Single submitter
- CENPN p.Tyr155Cys Uncertain significance Single submitter
- CENPN p.Val39Ala Uncertain significance Single submitter
All CENPN variants
Likely benign 4
- p.Arg60Cys Single submitter
- p.Ile251Val Single submitter
- p.Met74Thr Single submitter
- p.Val96Ile Single submitter
Uncertain significance 54
- p.Ala312Val Single submitter ⚠
- p.Ala61Gly Single submitter ⚠
- p.Arg292Gln Single submitter ⚠
- p.Arg42Gln Single submitter ⚠
- p.Arg60Leu Single submitter ⚠
- p.Asn280Ser Single submitter ⚠
- p.Asn34Asp Single submitter ⚠
- p.Asp199Glu Single submitter ⚠
- p.Asp2Glu Single submitter ⚠
- p.Cys293Tyr Single submitter ⚠
- p.Gln223Lys Single submitter ⚠
- p.Gln253Glu Single submitter ⚠
- p.Gln261Glu Single submitter ⚠
- p.Gln268Arg Single submitter ⚠
- p.Gln37His Single submitter ⚠
- p.Gln75His Single submitter ⚠
- p.Glu46Gln Single submitter ⚠
- p.Gly91Arg Single submitter ⚠
- p.His239Pro Single submitter ⚠
- p.His51Gln Single submitter ⚠
- p.His79Tyr Single submitter ⚠
- p.Ile111Val Single submitter ⚠
- p.Ile204Val Single submitter ⚠
- p.Ile295Thr Single submitter ⚠
- p.Ile9Thr Single submitter ⚠
- p.Leu264Val Single submitter ⚠
- p.Leu271Phe Single submitter ⚠
- p.Lys184Gln Single submitter ⚠
- p.Lys207Gln Single submitter ⚠
- p.Lys245Glu Single submitter ⚠
- p.Lys307Arg Single submitter ⚠
- p.Met101Arg Single submitter ⚠
- p.Met167Leu Single submitter ⚠
- p.Met18Ile Single submitter ⚠
- p.Phe30Val Single submitter ⚠
- p.Pro173Leu Single submitter ⚠
- p.Pro221Ser Single submitter ⚠
- p.Pro260Ala Single submitter ⚠
- p.Thr120Lys Single submitter ⚠
- p.Thr163Met Single submitter ⚠
- p.Thr212Ala Single submitter ⚠
- p.Thr219Met Single submitter ⚠
- p.Thr22Lys Single submitter ⚠
- p.Thr273Met Single submitter ⚠
- p.Thr38Ser Single submitter ⚠
- p.Tyr141Phe Single submitter ⚠
- p.Tyr154His Single submitter ⚠
- p.Tyr155Cys Single submitter ⚠
- p.Tyr197His Single submitter ⚠
- p.Val152Met Single submitter ⚠
- p.Val205Ala Single submitter ⚠
- p.Val39Ala Single submitter ⚠
- p.Val5Phe Single submitter ⚠
- p.Val85Ile Single submitter ⚠