CENPQ — 32 ClinVar variants
All ClinVar germline CENPQ variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
3 Likely benign · 29 Uncertain significance
Full CENPQ gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPQ p.Ala12Thr Uncertain significance Single submitter
- CENPQ p.Ala267Val Uncertain significance Single submitter
- CENPQ p.Asn181Asp Uncertain significance Single submitter
- CENPQ p.Asp241Glu Uncertain significance Single submitter
- CENPQ p.Asp243Asn Uncertain significance Single submitter
- CENPQ p.Gln14Arg Uncertain significance Single submitter
- CENPQ p.Gln216Pro Uncertain significance Single submitter
- CENPQ p.Glu144Gly Uncertain significance Single submitter
- CENPQ p.Glu195Asp Uncertain significance Single submitter
- CENPQ p.Glu227Asp Uncertain significance Single submitter
- CENPQ p.Gly207Ala Uncertain significance Single submitter
- CENPQ p.His201Arg Uncertain significance Single submitter
- CENPQ p.His45Arg Uncertain significance Single submitter
- CENPQ p.Ile95Val Uncertain significance Single submitter
- CENPQ p.Leu242Trp Uncertain significance Single submitter
- CENPQ p.Lys115Glu Uncertain significance Single submitter
- CENPQ p.Lys22Ile Uncertain significance Single submitter
- CENPQ p.Lys64Asn Uncertain significance Single submitter
- CENPQ p.Met131Lys Uncertain significance Single submitter
- CENPQ p.Met200Thr Uncertain significance Single submitter
- CENPQ p.Met88Thr Uncertain significance Single submitter
- CENPQ p.Pro128Thr Uncertain significance Single submitter
- CENPQ p.Ser206Asn Uncertain significance Single submitter
- CENPQ p.Ser2Phe Uncertain significance Single submitter
- CENPQ p.Thr123Ala Uncertain significance Single submitter
- CENPQ p.Thr168Ser Uncertain significance Single submitter
- CENPQ p.Thr58Ser Uncertain significance Single submitter
- CENPQ p.Val29Leu Uncertain significance Single submitter
- CENPQ p.Val91Glu Uncertain significance Single submitter
All CENPQ variants
Likely benign 3
- p.Ala230Thr Single submitter
- p.Arg147Gln Single submitter
- p.Pro127= Single submitter
Uncertain significance 29
- p.Ala12Thr Single submitter ⚠
- p.Ala267Val Single submitter ⚠
- p.Asn181Asp Single submitter ⚠
- p.Asp241Glu Single submitter ⚠
- p.Asp243Asn Single submitter ⚠
- p.Gln14Arg Single submitter ⚠
- p.Gln216Pro Single submitter ⚠
- p.Glu144Gly Single submitter ⚠
- p.Glu195Asp Single submitter ⚠
- p.Glu227Asp Single submitter ⚠
- p.Gly207Ala Single submitter ⚠
- p.His201Arg Single submitter ⚠
- p.His45Arg Single submitter ⚠
- p.Ile95Val Single submitter ⚠
- p.Leu242Trp Single submitter ⚠
- p.Lys115Glu Single submitter ⚠
- p.Lys22Ile Single submitter ⚠
- p.Lys64Asn Single submitter ⚠
- p.Met131Lys Single submitter ⚠
- p.Met200Thr Single submitter ⚠
- p.Met88Thr Single submitter ⚠
- p.Pro128Thr Single submitter ⚠
- p.Ser206Asn Single submitter ⚠
- p.Ser2Phe Single submitter ⚠
- p.Thr123Ala Single submitter ⚠
- p.Thr168Ser Single submitter ⚠
- p.Thr58Ser Single submitter ⚠
- p.Val29Leu Single submitter ⚠
- p.Val91Glu Single submitter ⚠