CENPU — 61 ClinVar variants
All ClinVar germline CENPU variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
6 Likely benign · 55 Uncertain significance
Full CENPU gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CENPU p.Ala115Val Uncertain significance Single submitter
- CENPU p.Ala169Thr Uncertain significance Single submitter
- CENPU p.Ala201Ser Uncertain significance Single submitter
- CENPU p.Ala400Thr Uncertain significance Single submitter
- CENPU p.Arg161His Uncertain significance Single submitter
- CENPU p.Arg347Thr Uncertain significance Single submitter
- CENPU p.Asp383Gly Uncertain significance Single submitter
- CENPU p.Asp45Val Uncertain significance Single submitter
- CENPU p.Gln288Arg Uncertain significance Single submitter
- CENPU p.Gln297Glu Uncertain significance Single submitter
- CENPU p.Gln36Pro Uncertain significance Single submitter
- CENPU p.Glu119Ala Uncertain significance Single submitter
- CENPU p.Glu119Lys Uncertain significance Single submitter
- CENPU p.Glu25Val Uncertain significance Single submitter
- CENPU p.Glu401Lys Uncertain significance Single submitter
- CENPU p.Glu66Lys Uncertain significance Single submitter
- CENPU p.Gly187Glu Uncertain significance Single submitter
- CENPU p.Gly212Arg Uncertain significance Single submitter
- CENPU p.Gly212Glu Uncertain significance Single submitter
- CENPU p.Gly92Arg Uncertain significance Single submitter
- CENPU p.His12Tyr Uncertain significance Single submitter
- CENPU p.His403Tyr Uncertain significance Single submitter
- CENPU p.His409Arg Uncertain significance Single submitter
- CENPU p.Ile165Met Uncertain significance Single submitter
- CENPU p.Ile407Thr Uncertain significance Single submitter
- CENPU p.Ile55Thr Uncertain significance Single submitter
- CENPU p.Leu391Ser Uncertain significance Single submitter
- CENPU p.Leu397Ile Uncertain significance Single submitter
- CENPU p.Lys122Gln Uncertain significance Single submitter
- CENPU p.Lys210Arg Uncertain significance Single submitter
- CENPU p.Met320Val Uncertain significance Single submitter
- CENPU p.Phe44Ser Uncertain significance Single submitter
- CENPU p.Pro11Leu Uncertain significance Single submitter
- CENPU p.Pro40Ser Uncertain significance Single submitter
- CENPU p.Ser88Phe Uncertain significance Single submitter
- CENPU p.Thr261Ile Uncertain significance Single submitter
- CENPU p.Tyr282Cys Uncertain significance Single submitter
- CENPU p.Val52Phe Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CENPU p.Ala277Ser Likely benign Single submitter
- CENPU p.Ala79Pro Uncertain significance Single submitter
- CENPU p.Arg19Cys Uncertain significance Single submitter
- CENPU p.Arg4Trp Uncertain significance Single submitter
- CENPU p.Arg6Pro Uncertain significance Single submitter
- CENPU p.Gln410Leu Uncertain significance Single submitter
- CENPU p.Glu65Gly Uncertain significance Single submitter
- CENPU p.Ile80Met Uncertain significance Single submitter
- CENPU p.Leu293Phe Uncertain significance Single submitter
- CENPU p.Leu364Phe Uncertain significance Single submitter
- CENPU p.Lys275Asn Uncertain significance Single submitter
- CENPU p.Pro332Ala Uncertain significance Single submitter
- CENPU p.Ser145Gly Uncertain significance Single submitter
- CENPU p.Ser14Cys Uncertain significance Single submitter
- CENPU p.Ser359Pro Uncertain significance Single submitter
- CENPU p.Thr381Met Uncertain significance Single submitter
- CENPU p.Tyr81Cys Uncertain significance Single submitter
- CENPU p.Val235Met Uncertain significance Single submitter
All CENPU variants
Likely benign 6
- p.Ala277Ser Single submitter ⚠
- p.Ala355Thr Single submitter
- p.Arg405Gln Single submitter
- p.Gly16= Single submitter
- p.Ile165Val Single submitter
- p.Ile41Val Single submitter
Uncertain significance 55
- p.Ala115Val Single submitter ⚠
- p.Ala169Thr Single submitter ⚠
- p.Ala201Ser Single submitter ⚠
- p.Ala400Thr Single submitter ⚠
- p.Ala79Pro Single submitter ⚠
- p.Arg161His Single submitter ⚠
- p.Arg19Cys Single submitter ⚠
- p.Arg347Thr Single submitter ⚠
- p.Arg4Trp Single submitter ⚠
- p.Arg6Pro Single submitter ⚠
- p.Asp383Gly Single submitter ⚠
- p.Asp45Val Single submitter ⚠
- p.Gln288Arg Single submitter ⚠
- p.Gln297Glu Single submitter ⚠
- p.Gln36Pro Single submitter ⚠
- p.Gln410Leu Single submitter ⚠
- p.Glu119Ala Single submitter ⚠
- p.Glu119Lys Single submitter ⚠
- p.Glu25Val Single submitter ⚠
- p.Glu401Lys Single submitter ⚠
- p.Glu65Gly Single submitter ⚠
- p.Glu66Lys Single submitter ⚠
- p.Gly187Glu Single submitter ⚠
- p.Gly212Arg Single submitter ⚠
- p.Gly212Glu Single submitter ⚠
- p.Gly92Arg Single submitter ⚠
- p.His12Tyr Single submitter ⚠
- p.His403Tyr Single submitter ⚠
- p.His409Arg Single submitter ⚠
- p.Ile165Met Single submitter ⚠
- p.Ile407Thr Single submitter ⚠
- p.Ile55Thr Single submitter ⚠
- p.Ile80Met Single submitter ⚠
- p.Leu293Phe Single submitter ⚠
- p.Leu364Phe Single submitter ⚠
- p.Leu391Ser Single submitter ⚠
- p.Leu397Ile Single submitter ⚠
- p.Lys122Gln Single submitter ⚠
- p.Lys210Arg Single submitter ⚠
- p.Lys275Asn Single submitter ⚠
- p.Met320Val Single submitter ⚠
- p.Phe44Ser Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro332Ala Single submitter ⚠
- p.Pro40Ser Single submitter ⚠
- p.Ser145Gly Single submitter ⚠
- p.Ser14Cys Single submitter ⚠
- p.Ser359Pro Single submitter ⚠
- p.Ser88Phe Single submitter ⚠
- p.Thr261Ile Single submitter ⚠
- p.Thr381Met Single submitter ⚠
- p.Tyr282Cys Single submitter ⚠
- p.Tyr81Cys Single submitter ⚠
- p.Val235Met Single submitter ⚠
- p.Val52Phe Single submitter ⚠