CENPW — 11 ClinVar variants
All ClinVar germline CENPW variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
11 Uncertain significance
Full CENPW gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 8
The independent predictors disagree with each other — read with care.
- CENPW p.Ala62Thr Uncertain significance Single submitter
- CENPW p.Arg59Gly Uncertain significance Single submitter
- CENPW p.Gly39Val Uncertain significance Single submitter
- CENPW p.His44Gln Uncertain significance Single submitter
- CENPW p.His74Arg Uncertain significance Single submitter
- CENPW p.Pro31Arg Uncertain significance Single submitter
- CENPW p.Pro31Leu Uncertain significance Single submitter
- CENPW p.Val69Gly Uncertain significance Single submitter
All CENPW variants
Uncertain significance 11
- p.Ala62Thr Single submitter ⚠
- p.Arg59Gly Single submitter ⚠
- p.Asn61Ile Single submitter ⚠
- p.Gly39Val Single submitter ⚠
- p.His44Arg Single submitter ⚠
- p.His44Gln Single submitter ⚠
- p.His74Arg Single submitter ⚠
- p.Lys11Asn Single submitter ⚠
- p.Pro31Arg Single submitter ⚠
- p.Pro31Leu Single submitter ⚠
- p.Val69Gly Single submitter ⚠