CEP95 — 131 ClinVar variants
All ClinVar germline CEP95 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 124 flagged for review →
9 Likely benign · 122 Uncertain significance
Full CEP95 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 124
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 101
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CEP95 p.Ala188Val Uncertain significance Single submitter
- CEP95 p.Ala592Glu Uncertain significance Single submitter
- CEP95 p.Ala601Ser Uncertain significance Single submitter
- CEP95 p.Ala601Thr Uncertain significance Single submitter
- CEP95 p.Ala679Val Uncertain significance Single submitter
- CEP95 p.Arg134Gln Uncertain significance Single submitter
- CEP95 p.Arg183Gly Uncertain significance Single submitter
- CEP95 p.Arg273Gln Uncertain significance Single submitter
- CEP95 p.Arg358Lys Uncertain significance Single submitter
- CEP95 p.Arg378Gln Uncertain significance Single submitter
- CEP95 p.Arg465Lys Uncertain significance Single submitter
- CEP95 p.Arg467Gly Uncertain significance Single submitter
- CEP95 p.Arg469His Uncertain significance Single submitter
- CEP95 p.Arg472Thr Uncertain significance Single submitter
- CEP95 p.Arg56Ser Uncertain significance Single submitter
- CEP95 p.Arg770Thr Uncertain significance Single submitter
- CEP95 p.Arg797Gln Uncertain significance Single submitter
- CEP95 p.Arg807Gln Uncertain significance Single submitter
- CEP95 p.Asn196Asp Uncertain significance Single submitter
- CEP95 p.Asn344Lys Uncertain significance Single submitter
- CEP95 p.Asn456Asp Uncertain significance Single submitter
- CEP95 p.Asp186Glu Uncertain significance Single submitter
- CEP95 p.Asp75Val Uncertain significance Single submitter
- CEP95 p.Cys19Arg Uncertain significance Single submitter
- CEP95 p.Gln327Arg Uncertain significance Single submitter
- CEP95 p.Gln366Arg Uncertain significance Single submitter
- CEP95 p.Gln498Arg Uncertain significance Single submitter
- CEP95 p.Gln498Glu Uncertain significance Single submitter
- CEP95 p.Gln782Arg Uncertain significance Single submitter
- CEP95 p.Gln78His Uncertain significance Single submitter
- CEP95 p.Gln814Pro Uncertain significance Single submitter
- CEP95 p.Glu139Lys Uncertain significance Single submitter
- CEP95 p.Glu297Gln Uncertain significance Single submitter
- CEP95 p.Glu343Lys Uncertain significance Single submitter
- CEP95 p.Glu396Asp Uncertain significance Single submitter
- CEP95 p.Glu409Ala Uncertain significance Single submitter
- CEP95 p.Glu409Asp Uncertain significance Single submitter
- CEP95 p.Glu750Lys Uncertain significance Single submitter
- CEP95 p.Glu802Lys Uncertain significance Single submitter
- CEP95 p.Gly106Asp Uncertain significance Single submitter
- CEP95 p.Gly303Arg Uncertain significance Single submitter
- CEP95 p.Gly519Glu Uncertain significance Single submitter
- CEP95 p.His120Arg Uncertain significance Single submitter
- CEP95 p.His120Gln Uncertain significance Single submitter
- CEP95 p.His20Arg Uncertain significance Single submitter
- CEP95 p.His268Leu Uncertain significance Single submitter
- CEP95 p.His400Arg Uncertain significance Single submitter
- CEP95 p.His507Gln Uncertain significance Single submitter
- CEP95 p.Ile21Val Uncertain significance Single submitter
- CEP95 p.Ile261Val Uncertain significance Single submitter
- CEP95 p.Ile278Met Uncertain significance Single submitter
- CEP95 p.Ile278Thr Uncertain significance Single submitter
- CEP95 p.Ile394Met Uncertain significance Single submitter
- CEP95 p.Ile43Val Uncertain significance Single submitter
- CEP95 p.Ile52Val Uncertain significance Single submitter
- CEP95 p.Ile615Thr Uncertain significance Single submitter
- CEP95 p.Ile69Thr Uncertain significance Single submitter
- CEP95 p.Ile747Val Uncertain significance Single submitter
- CEP95 p.Ile787Thr Uncertain significance Single submitter
- CEP95 p.Leu138Phe Uncertain significance Single submitter
- CEP95 p.Leu138Ser Uncertain significance Single submitter
- CEP95 p.Leu15Arg Uncertain significance Single submitter
- CEP95 p.Leu23Pro Uncertain significance Single submitter
- CEP95 p.Leu253Val Uncertain significance Single submitter
- CEP95 p.Leu283Val Uncertain significance Single submitter
- CEP95 p.Leu624Phe Uncertain significance Single submitter
- CEP95 p.Lys208Arg Uncertain significance Single submitter
- CEP95 p.Lys320Thr Uncertain significance Single submitter
- CEP95 p.Lys340Arg Uncertain significance Single submitter
- CEP95 p.Lys466Arg Uncertain significance Single submitter
- CEP95 p.Lys551Glu Uncertain significance Single submitter
- CEP95 p.Lys715Arg Uncertain significance Single submitter
- CEP95 p.Lys775Glu Uncertain significance Single submitter
- CEP95 p.Met221Thr Uncertain significance Single submitter
- CEP95 p.Met732Leu Uncertain significance Single submitter
- CEP95 p.Met786Ile Uncertain significance Single submitter
- CEP95 p.Phe129Leu Uncertain significance Single submitter
- CEP95 p.Phe642Val Uncertain significance Single submitter
- CEP95 p.Pro141Ala Uncertain significance Single submitter
- CEP95 p.Pro225Ala Uncertain significance Single submitter
- CEP95 p.Pro225Ser Uncertain significance Single submitter
- CEP95 p.Pro325Ala Uncertain significance Single submitter
- CEP95 p.Ser243Thr Uncertain significance Single submitter
- CEP95 p.Ser438Pro Uncertain significance Single submitter
- CEP95 p.Ser537Pro Uncertain significance Single submitter
- CEP95 p.Ser564Thr Uncertain significance Single submitter
- CEP95 p.Ser584Arg Uncertain significance Single submitter
- CEP95 p.Ser760Tyr Uncertain significance Single submitter
- CEP95 p.Ser96Tyr Uncertain significance Single submitter
- CEP95 p.Thr299Ala Uncertain significance Single submitter
- CEP95 p.Thr414Ser Uncertain significance Single submitter
- CEP95 p.Thr417Lys Uncertain significance Single submitter
- CEP95 p.Thr582Arg Uncertain significance Single submitter
- CEP95 p.Trp151Gly Uncertain significance Single submitter
- CEP95 p.Tyr110Cys Uncertain significance Single submitter
- CEP95 p.Tyr40Asn Uncertain significance Single submitter
- CEP95 p.Tyr673Cys Uncertain significance Single submitter
- CEP95 p.Val410Ala Uncertain significance Single submitter
- CEP95 p.Val48Ile Uncertain significance Single submitter
- CEP95 p.Val594Phe Uncertain significance Single submitter
- CEP95 p.Val794Ile Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CEP95 p.Ala2Thr Uncertain significance Single submitter
- CEP95 p.Arg378Trp Uncertain significance Single submitter
- CEP95 p.Arg393Trp Uncertain significance Single submitter
- CEP95 p.Arg477His Likely benign Single submitter
- CEP95 p.Arg683Ile Uncertain significance Single submitter
- CEP95 p.Arg708Pro Uncertain significance Single submitter
- CEP95 p.Arg724Cys Uncertain significance Single submitter
- CEP95 p.Arg797Trp Uncertain significance Single submitter
- CEP95 p.Arg803Cys Uncertain significance Single submitter
- CEP95 p.Asn34Asp Uncertain significance Single submitter
- CEP95 p.Asp60Glu Uncertain significance Single submitter
- CEP95 p.Glu720Gly Uncertain significance Single submitter
- CEP95 p.Glu750Asp Uncertain significance Single submitter
- CEP95 p.Gly254Glu Uncertain significance Single submitter
- CEP95 p.Ile21Met Uncertain significance Single submitter
- CEP95 p.Ile84Val Uncertain significance Single submitter
- CEP95 p.Leu16Val Uncertain significance Single submitter
- CEP95 p.Lys759Asn Uncertain significance Single submitter
- CEP95 p.Pro567Ser Uncertain significance Single submitter
- CEP95 p.Ser449Leu Uncertain significance Single submitter
- CEP95 p.Ser806Pro Uncertain significance Single submitter
- CEP95 p.Thr187Ile Uncertain significance Single submitter
- CEP95 p.Thr299Met Likely benign Single submitter
All CEP95 variants
Likely benign 9
- p.Arg477His Single submitter ⚠
- p.Arg647His Single submitter
- p.His218Arg Single submitter
- p.Ile11Val Single submitter
- p.Met439Val Single submitter
- p.Thr299Met Single submitter ⚠
- p.Tyr428Cys Single submitter
- p.Val426Met Single submitter
- p.Val594Ile Single submitter
Uncertain significance 122
- p.Ala188Val Single submitter ⚠
- p.Ala2Thr Single submitter ⚠
- p.Ala592Glu Single submitter ⚠
- p.Ala601Ser Single submitter ⚠
- p.Ala601Thr Single submitter ⚠
- p.Ala679Val Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg183Gly Single submitter ⚠
- p.Arg273Gln Single submitter ⚠
- p.Arg358Lys Single submitter ⚠
- p.Arg378Gln Single submitter ⚠
- p.Arg378Trp Single submitter ⚠
- p.Arg393Trp Single submitter ⚠
- p.Arg465Lys Single submitter ⚠
- p.Arg467Gly Single submitter ⚠
- p.Arg469His Single submitter ⚠
- p.Arg472Thr Single submitter ⚠
- p.Arg56Ser Single submitter ⚠
- p.Arg683Ile Single submitter ⚠
- p.Arg708Pro Single submitter ⚠
- p.Arg724Cys Single submitter ⚠
- p.Arg770Thr Single submitter ⚠
- p.Arg797Gln Single submitter ⚠
- p.Arg797Trp Single submitter ⚠
- p.Arg803Cys Single submitter ⚠
- p.Arg807Gln Single submitter ⚠
- p.Asn196Asp Single submitter ⚠
- p.Asn344Lys Single submitter ⚠
- p.Asn34Asp Single submitter ⚠
- p.Asn456Asp Single submitter ⚠
- p.Asp186Glu Single submitter ⚠
- p.Asp60Glu Single submitter ⚠
- p.Asp75Val Single submitter ⚠
- p.Cys19Arg Single submitter ⚠
- p.Gln327Arg Single submitter ⚠
- p.Gln366Arg Single submitter ⚠
- p.Gln498Arg Single submitter ⚠
- p.Gln498Glu Single submitter ⚠
- p.Gln782Arg Single submitter ⚠
- p.Gln78His Single submitter ⚠
- p.Gln814Pro Single submitter ⚠
- p.Glu139Lys Single submitter ⚠
- p.Glu297Gln Single submitter ⚠
- p.Glu343Lys Single submitter ⚠
- p.Glu396Asp Single submitter ⚠
- p.Glu409Ala Single submitter ⚠
- p.Glu409Asp Single submitter ⚠
- p.Glu720Gly Single submitter ⚠
- p.Glu750Asp Single submitter ⚠
- p.Glu750Lys Single submitter ⚠
- p.Glu802Lys Single submitter ⚠
- p.Gly106Asp Single submitter ⚠
- p.Gly254Glu Single submitter ⚠
- p.Gly303Arg Single submitter ⚠
- p.Gly519Glu Single submitter ⚠
- p.His120Arg Single submitter ⚠
- p.His120Gln Single submitter ⚠
- p.His20Arg Single submitter ⚠
- p.His268Leu Single submitter ⚠
- p.His400Arg Single submitter ⚠
- p.His507Gln Single submitter ⚠
- p.Ile21Met Single submitter ⚠
- p.Ile21Val Single submitter ⚠
- p.Ile261Val Single submitter ⚠
- p.Ile278Met Single submitter ⚠
- p.Ile278Thr Single submitter ⚠
- p.Ile394Met Single submitter ⚠
- p.Ile43Val Single submitter ⚠
- p.Ile52Val Single submitter ⚠
- p.Ile615Thr Single submitter ⚠
- p.Ile69Thr Single submitter ⚠
- p.Ile747Val Single submitter ⚠
- p.Ile787Thr Single submitter ⚠
- p.Ile84Val Single submitter ⚠
- p.Leu138Phe Single submitter ⚠
- p.Leu138Ser Single submitter ⚠
- p.Leu15Arg Single submitter ⚠
- p.Leu16Val Single submitter ⚠
- p.Leu23Pro Single submitter ⚠
- p.Leu253Val Single submitter ⚠
- p.Leu283Val Single submitter ⚠
- p.Leu624Phe Single submitter ⚠
- p.Lys208Arg Single submitter ⚠
- p.Lys320Thr Single submitter ⚠
- p.Lys340Arg Single submitter ⚠
- p.Lys466Arg Single submitter ⚠
- p.Lys551Glu Single submitter ⚠
- p.Lys715Arg Single submitter ⚠
- p.Lys759Asn Single submitter ⚠
- p.Lys775Glu Single submitter ⚠
- p.Met221Thr Single submitter ⚠
- p.Met732Leu Single submitter ⚠
- p.Met786Ile Single submitter ⚠
- p.Phe129Leu Single submitter ⚠
- p.Phe642Val Single submitter ⚠
- p.Pro141Ala Single submitter ⚠
- p.Pro225Ala Single submitter ⚠
- p.Pro225Ser Single submitter ⚠
- p.Pro325Ala Single submitter ⚠
- p.Pro567Ser Single submitter ⚠
- p.Ser243Thr Single submitter ⚠
- p.Ser438Pro Single submitter ⚠
- p.Ser449Leu Single submitter ⚠
- p.Ser537Pro Single submitter ⚠
- p.Ser564Thr Single submitter ⚠
- p.Ser584Arg Single submitter ⚠
- p.Ser760Tyr Single submitter ⚠
- p.Ser806Pro Single submitter ⚠
- p.Ser96Tyr Single submitter ⚠
- p.Thr187Ile Single submitter ⚠
- p.Thr299Ala Single submitter ⚠
- p.Thr414Ser Single submitter ⚠
- p.Thr417Lys Single submitter ⚠
- p.Thr582Arg Single submitter ⚠
- p.Trp151Gly Single submitter ⚠
- p.Tyr110Cys Single submitter ⚠
- p.Tyr40Asn Single submitter ⚠
- p.Tyr673Cys Single submitter ⚠
- p.Val410Ala Single submitter ⚠
- p.Val48Ile Single submitter ⚠
- p.Val594Phe Single submitter ⚠
- p.Val794Ile Single submitter ⚠