CERCAM — 121 ClinVar variants
All ClinVar germline CERCAM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 117 flagged for review →
4 Likely benign · 117 Uncertain significance
Full CERCAM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 117
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CERCAM p.Ala294Gly Uncertain significance Single submitter
- CERCAM p.Ala39Thr Uncertain significance Single submitter
- CERCAM p.Ala534Thr Uncertain significance Single submitter
- CERCAM p.Ala543Asp Uncertain significance Single submitter
- CERCAM p.Ala543Thr Uncertain significance Single submitter
- CERCAM p.Arg205Gln Uncertain significance Single submitter
- CERCAM p.Arg2Gly Uncertain significance Single submitter
- CERCAM p.Arg300Cys Uncertain significance Single submitter
- CERCAM p.Arg300His Uncertain significance Single submitter
- CERCAM p.Arg480Cys Uncertain significance Single submitter
- CERCAM p.Arg480His Uncertain significance Single submitter
- CERCAM p.Arg495His Uncertain significance Single submitter
- CERCAM p.Arg495Pro Uncertain significance Single submitter
- CERCAM p.Arg573His Uncertain significance Single submitter
- CERCAM p.Arg5Gly Uncertain significance Single submitter
- CERCAM p.Asn135Lys Uncertain significance Single submitter
- CERCAM p.Asn153Ser Uncertain significance Single submitter
- CERCAM p.Asn452Lys Uncertain significance Single submitter
- CERCAM p.Gln187Glu Uncertain significance Single submitter
- CERCAM p.Gln530His Uncertain significance Single submitter
- CERCAM p.Glu27Ala Uncertain significance Single submitter
- CERCAM p.Glu293Gln Uncertain significance Single submitter
- CERCAM p.Glu43Ala Uncertain significance Single submitter
- CERCAM p.Glu501Lys Uncertain significance Single submitter
- CERCAM p.Glu54Gln Uncertain significance Single submitter
- CERCAM p.Gly279Glu Uncertain significance Single submitter
- CERCAM p.Gly447Arg Uncertain significance Single submitter
- CERCAM p.Gly483Asp Uncertain significance Single submitter
- CERCAM p.Gly567Ser Uncertain significance Single submitter
- CERCAM p.Gly567Val Uncertain significance Single submitter
- CERCAM p.His306Leu Uncertain significance Single submitter
- CERCAM p.His395Asp Uncertain significance Single submitter
- CERCAM p.Ile346Val Uncertain significance Single submitter
- CERCAM p.Ile37Val Uncertain significance Single submitter
- CERCAM p.Ile563Met Uncertain significance Single submitter
- CERCAM p.Leu30Arg Uncertain significance Single submitter
- CERCAM p.Leu371Val Uncertain significance Single submitter
- CERCAM p.Leu587Pro Uncertain significance Single submitter
- CERCAM p.Lys316Arg Uncertain significance Single submitter
- CERCAM p.Lys486Glu Uncertain significance Single submitter
- CERCAM p.Met160Leu Uncertain significance Single submitter
- CERCAM p.Phe231Ile Uncertain significance Single submitter
- CERCAM p.Phe231Leu Uncertain significance Single submitter
- CERCAM p.Phe248Val Uncertain significance Single submitter
- CERCAM p.Phe527Ser Uncertain significance Single submitter
- CERCAM p.Pro18Ser Uncertain significance Single submitter
- CERCAM p.Pro29Leu Uncertain significance Single submitter
- CERCAM p.Pro29Ser Uncertain significance Single submitter
- CERCAM p.Pro463Ser Uncertain significance Single submitter
- CERCAM p.Ser340Trp Uncertain significance Single submitter
- CERCAM p.Ser380Leu Uncertain significance Single submitter
- CERCAM p.Ser490Ala Uncertain significance Single submitter
- CERCAM p.Ser553Phe Uncertain significance Single submitter
- CERCAM p.Ser586Gly Uncertain significance Single submitter
- CERCAM p.Thr216Ile Uncertain significance Single submitter
- CERCAM p.Thr76Asn Uncertain significance Single submitter
- CERCAM p.Tyr267Cys Uncertain significance Single submitter
- CERCAM p.Tyr375Cys Uncertain significance Single submitter
- CERCAM p.Tyr91Asp Uncertain significance Single submitter
- CERCAM p.Val247Ile Uncertain significance Single submitter
- CERCAM p.Val451Met Uncertain significance Single submitter
Predictors split 56
The independent predictors disagree with each other — read with care.
- CERCAM p.Ala353Thr Uncertain significance Single submitter
- CERCAM p.Ala489Thr Uncertain significance Single submitter
- CERCAM p.Ala93Val Uncertain significance Single submitter
- CERCAM p.Arg157Trp Uncertain significance Single submitter
- CERCAM p.Arg202Cys Uncertain significance Single submitter
- CERCAM p.Arg209Cys Uncertain significance Single submitter
- CERCAM p.Arg209His Uncertain significance Single submitter
- CERCAM p.Arg266His Uncertain significance Single submitter
- CERCAM p.Arg329Cys Uncertain significance Single submitter
- CERCAM p.Arg333His Uncertain significance Single submitter
- CERCAM p.Arg334Gln Uncertain significance Single submitter
- CERCAM p.Arg334Trp Uncertain significance Single submitter
- CERCAM p.Arg336Cys Uncertain significance Single submitter
- CERCAM p.Arg382Cys Uncertain significance Single submitter
- CERCAM p.Arg409Trp Uncertain significance Single submitter
- CERCAM p.Arg418Cys Uncertain significance Single submitter
- CERCAM p.Arg418His Uncertain significance Single submitter
- CERCAM p.Arg426Gln Uncertain significance Single submitter
- CERCAM p.Arg485Leu Uncertain significance Single submitter
- CERCAM p.Arg494Cys Uncertain significance Single submitter
- CERCAM p.Arg494His Uncertain significance Single submitter
- CERCAM p.Arg522Gln Uncertain significance Single submitter
- CERCAM p.Arg561Cys Uncertain significance Single submitter
- CERCAM p.Arg561His Uncertain significance Single submitter
- CERCAM p.Asn75Ser Uncertain significance Single submitter
- CERCAM p.Asp508Asn Uncertain significance Single submitter
- CERCAM p.Asp89Asn Uncertain significance Single submitter
- CERCAM p.Gln187Arg Uncertain significance Single submitter
- CERCAM p.Gln509His Uncertain significance Single submitter
- CERCAM p.Glu321Lys Uncertain significance Single submitter
- CERCAM p.Glu513Lys Uncertain significance Single submitter
- CERCAM p.Gly318Glu Uncertain significance Single submitter
- CERCAM p.Gly541Arg Uncertain significance Single submitter
- CERCAM p.Gly560Ser Uncertain significance Single submitter
- CERCAM p.His113Arg Uncertain significance Single submitter
- CERCAM p.His306Gln Uncertain significance Single submitter
- CERCAM p.Leu487Val Uncertain significance Single submitter
- CERCAM p.Leu524Val Uncertain significance Single submitter
- CERCAM p.Met270Val Uncertain significance Single submitter
- CERCAM p.Phe197Leu Uncertain significance Single submitter
- CERCAM p.Phe527Val Uncertain significance Single submitter
- CERCAM p.Pro106Ser Uncertain significance Single submitter
- CERCAM p.Pro165Gln Uncertain significance Single submitter
- CERCAM p.Pro233Leu Uncertain significance Single submitter
- CERCAM p.Pro236Arg Uncertain significance Single submitter
- CERCAM p.Pro373Leu Uncertain significance Single submitter
- CERCAM p.Pro378Leu Uncertain significance Single submitter
- CERCAM p.Thr474Met Uncertain significance Single submitter
- CERCAM p.Thr69Met Uncertain significance Single submitter
- CERCAM p.Tyr472Cys Uncertain significance Single submitter
- CERCAM p.Tyr49Cys Uncertain significance Single submitter
- CERCAM p.Val261Met Uncertain significance Single submitter
- CERCAM p.Val274Ala Uncertain significance Single submitter
- CERCAM p.Val417Met Uncertain significance Single submitter
- CERCAM p.Val459Met Uncertain significance Single submitter
- CERCAM p.Val94Gly Uncertain significance Single submitter
All CERCAM variants
Likely benign 4
- p.Ala339Thr Single submitter
- p.Asn512= Single submitter
- p.Pro18Leu Single submitter
- p.Ser258Ala Single submitter
Uncertain significance 117
- p.Ala294Gly Single submitter ⚠
- p.Ala353Thr Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Ala489Thr Single submitter ⚠
- p.Ala534Thr Single submitter ⚠
- p.Ala543Asp Single submitter ⚠
- p.Ala543Thr Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg157Trp Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg209Cys Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg266His Single submitter ⚠
- p.Arg2Gly Single submitter ⚠
- p.Arg300Cys Single submitter ⚠
- p.Arg300His Single submitter ⚠
- p.Arg329Cys Single submitter ⚠
- p.Arg333His Single submitter ⚠
- p.Arg334Gln Single submitter ⚠
- p.Arg334Trp Single submitter ⚠
- p.Arg336Cys Single submitter ⚠
- p.Arg382Cys Single submitter ⚠
- p.Arg409Trp Single submitter ⚠
- p.Arg418Cys Single submitter ⚠
- p.Arg418His Single submitter ⚠
- p.Arg426Gln Single submitter ⚠
- p.Arg480Cys Single submitter ⚠
- p.Arg480His Single submitter ⚠
- p.Arg485Leu Single submitter ⚠
- p.Arg494Cys Single submitter ⚠
- p.Arg494His Single submitter ⚠
- p.Arg495His Single submitter ⚠
- p.Arg495Pro Single submitter ⚠
- p.Arg522Gln Single submitter ⚠
- p.Arg561Cys Single submitter ⚠
- p.Arg561His Single submitter ⚠
- p.Arg573His Single submitter ⚠
- p.Arg5Gly Single submitter ⚠
- p.Asn135Lys Single submitter ⚠
- p.Asn153Ser Single submitter ⚠
- p.Asn452Lys Single submitter ⚠
- p.Asn75Ser Single submitter ⚠
- p.Asp508Asn Single submitter ⚠
- p.Asp89Asn Single submitter ⚠
- p.Gln187Arg Single submitter ⚠
- p.Gln187Glu Single submitter ⚠
- p.Gln509His Single submitter ⚠
- p.Gln530His Single submitter ⚠
- p.Glu27Ala Single submitter ⚠
- p.Glu293Gln Single submitter ⚠
- p.Glu321Lys Single submitter ⚠
- p.Glu43Ala Single submitter ⚠
- p.Glu501Lys Single submitter ⚠
- p.Glu513Lys Single submitter ⚠
- p.Glu54Gln Single submitter ⚠
- p.Gly279Glu Single submitter ⚠
- p.Gly318Glu Single submitter ⚠
- p.Gly447Arg Single submitter ⚠
- p.Gly483Asp Single submitter ⚠
- p.Gly541Arg Single submitter ⚠
- p.Gly560Ser Single submitter ⚠
- p.Gly567Ser Single submitter ⚠
- p.Gly567Val Single submitter ⚠
- p.His113Arg Single submitter ⚠
- p.His306Gln Single submitter ⚠
- p.His306Leu Single submitter ⚠
- p.His395Asp Single submitter ⚠
- p.Ile346Val Single submitter ⚠
- p.Ile37Val Single submitter ⚠
- p.Ile563Met Single submitter ⚠
- p.Leu30Arg Single submitter ⚠
- p.Leu371Val Single submitter ⚠
- p.Leu487Val Single submitter ⚠
- p.Leu524Val Single submitter ⚠
- p.Leu587Pro Single submitter ⚠
- p.Lys316Arg Single submitter ⚠
- p.Lys486Glu Single submitter ⚠
- p.Met160Leu Single submitter ⚠
- p.Met270Val Single submitter ⚠
- p.Phe197Leu Single submitter ⚠
- p.Phe231Ile Single submitter ⚠
- p.Phe231Leu Single submitter ⚠
- p.Phe248Val Single submitter ⚠
- p.Phe527Ser Single submitter ⚠
- p.Phe527Val Single submitter ⚠
- p.Pro106Ser Single submitter ⚠
- p.Pro165Gln Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro233Leu Single submitter ⚠
- p.Pro236Arg Single submitter ⚠
- p.Pro29Leu Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Pro373Leu Single submitter ⚠
- p.Pro378Leu Single submitter ⚠
- p.Pro463Ser Single submitter ⚠
- p.Ser340Trp Single submitter ⚠
- p.Ser380Leu Single submitter ⚠
- p.Ser490Ala Single submitter ⚠
- p.Ser553Phe Single submitter ⚠
- p.Ser586Gly Single submitter ⚠
- p.Thr216Ile Single submitter ⚠
- p.Thr474Met Single submitter ⚠
- p.Thr69Met Single submitter ⚠
- p.Thr76Asn Single submitter ⚠
- p.Tyr267Cys Single submitter ⚠
- p.Tyr375Cys Single submitter ⚠
- p.Tyr472Cys Single submitter ⚠
- p.Tyr49Cys Single submitter ⚠
- p.Tyr91Asp Single submitter ⚠
- p.Val247Ile Single submitter ⚠
- p.Val261Met Single submitter ⚠
- p.Val274Ala Single submitter ⚠
- p.Val417Met Single submitter ⚠
- p.Val451Met Single submitter ⚠
- p.Val459Met Single submitter ⚠
- p.Val94Gly Single submitter ⚠