CERK — 110 ClinVar variants
All ClinVar germline CERK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
3 Benign · 7 Likely benign · 100 Uncertain significance
Full CERK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CERK p.Ala254Thr Uncertain significance Single submitter
- CERK p.Ala28Glu Uncertain significance Single submitter
- CERK p.Ala374Thr Uncertain significance Single submitter
- CERK p.Ala393Gly Uncertain significance Single submitter
- CERK p.Ala7Val Uncertain significance Single submitter
- CERK p.Arg120Gln Uncertain significance Single submitter
- CERK p.Arg148Gln Uncertain significance Single submitter
- CERK p.Arg223Gln Uncertain significance Single submitter
- CERK p.Arg348Trp Uncertain significance Single submitter
- CERK p.Arg401Cys Uncertain significance Single submitter
- CERK p.Arg454Cys Uncertain significance Single submitter
- CERK p.Arg454His Uncertain significance Single submitter
- CERK p.Arg479His Uncertain significance Single submitter
- CERK p.Arg94Gln Uncertain significance Single submitter
- CERK p.Arg96Cys Uncertain significance Single submitter
- CERK p.Arg96His Uncertain significance Single submitter
- CERK p.Asp189Tyr Uncertain significance Single submitter
- CERK p.Asp343Tyr Uncertain significance Single submitter
- CERK p.Gln117His Uncertain significance Single submitter
- CERK p.Gln76Arg Uncertain significance Single submitter
- CERK p.Glu109Lys Uncertain significance Single submitter
- CERK p.Glu121Lys Uncertain significance Single submitter
- CERK p.Gly196Arg Uncertain significance Single submitter
- CERK p.Gly294Arg Uncertain significance Single submitter
- CERK p.Gly475Val Uncertain significance Single submitter
- CERK p.Gly503Glu Uncertain significance Single submitter
- CERK p.Gly5Arg Uncertain significance Single submitter
- CERK p.Gly67Arg Uncertain significance Single submitter
- CERK p.Gly67Glu Uncertain significance Single submitter
- CERK p.Ile185Val Uncertain significance Single submitter
- CERK p.Ile483Val Uncertain significance Single submitter
- CERK p.Leu267Met Uncertain significance Single submitter
- CERK p.Lys477Arg Uncertain significance Single submitter
- CERK p.Met465Leu Uncertain significance Single submitter
- CERK p.Met78Leu Uncertain significance Single submitter
- CERK p.Phe136Ser Uncertain significance Single submitter
- CERK p.Pro139Leu Uncertain significance Single submitter
- CERK p.Ser278Arg Uncertain significance Single submitter
- CERK p.Ser489Cys Uncertain significance Single submitter
- CERK p.Thr337Met Uncertain significance Single submitter
- CERK p.Thr4Ser Uncertain significance Single submitter
- CERK p.Trp99Gly Uncertain significance Single submitter
- CERK p.Val494Ile Uncertain significance Single submitter
- CERK p.Val54Leu Uncertain significance Single submitter
- CERK p.Val65Ile Uncertain significance Single submitter
- CERK p.Val89Ala Uncertain significance Single submitter
Predictors split 54
The independent predictors disagree with each other — read with care.
- CERK p.Ala215Thr Uncertain significance Single submitter
- CERK p.Ala215Val Uncertain significance Single submitter
- CERK p.Ala238Ser Uncertain significance Single submitter
- CERK p.Ala238Thr Uncertain significance Single submitter
- CERK p.Ala258Val Uncertain significance Single submitter
- CERK p.Ala44Gly Uncertain significance Single submitter
- CERK p.Ala6Val Uncertain significance Single submitter
- CERK p.Arg120Trp Uncertain significance Single submitter
- CERK p.Arg223Trp Uncertain significance Single submitter
- CERK p.Arg232Leu Uncertain significance Single submitter
- CERK p.Arg232Trp Uncertain significance Single submitter
- CERK p.Arg282Cys Uncertain significance Single submitter
- CERK p.Arg282His Uncertain significance Single submitter
- CERK p.Arg29Pro Uncertain significance Single submitter
- CERK p.Arg402Gln Uncertain significance Single submitter
- CERK p.Arg402Trp Uncertain significance Single submitter
- CERK p.Arg424Gln Uncertain significance Single submitter
- CERK p.Arg94Trp Uncertain significance Single submitter
- CERK p.Asp189Asn Uncertain significance Single submitter
- CERK p.Asp189His Uncertain significance Single submitter
- CERK p.Asp218Asn Uncertain significance Single submitter
- CERK p.Asp253Asn Uncertain significance Single submitter
- CERK p.Cys106Tyr Uncertain significance Single submitter
- CERK p.Cys484Tyr Uncertain significance Single submitter
- CERK p.Glu255Asp Uncertain significance Single submitter
- CERK p.Glu26Lys Uncertain significance Single submitter
- CERK p.Glu362Asp Uncertain significance Single submitter
- CERK p.Glu364Gly Uncertain significance Single submitter
- CERK p.Glu8Asp Uncertain significance Single submitter
- CERK p.Gly146Ser Uncertain significance Single submitter
- CERK p.Gly206Ser Uncertain significance Single submitter
- CERK p.Gly216Arg Uncertain significance Single submitter
- CERK p.Ile163Val Uncertain significance Single submitter
- CERK p.Ile191Phe Uncertain significance Single submitter
- CERK p.Ile296Asn Uncertain significance Single submitter
- CERK p.Leu25Val Uncertain significance Single submitter
- CERK p.Leu407Val Uncertain significance Single submitter
- CERK p.Leu472Phe Uncertain significance Single submitter
- CERK p.Met199Ile Uncertain significance Single submitter
- CERK p.Phe447Leu Uncertain significance Single submitter
- CERK p.Pro409Leu Uncertain significance Single submitter
- CERK p.Pro45Ser Uncertain significance Single submitter
- CERK p.Ser201Asn Uncertain significance Single submitter
- CERK p.Ser321Phe Uncertain significance Single submitter
- CERK p.Ser321Pro Uncertain significance Single submitter
- CERK p.Ser462Leu Uncertain significance Single submitter
- CERK p.Tyr453Asp Uncertain significance Single submitter
- CERK p.Val169Gly Uncertain significance Single submitter
- CERK p.Val192Ile Uncertain significance Single submitter
- CERK p.Val262Ala Uncertain significance Single submitter
- CERK p.Val384Ala Uncertain significance Single submitter
- CERK p.Val384Phe Uncertain significance Single submitter
- CERK p.Val513Ile Uncertain significance Single submitter
- CERK p.Val513Phe Uncertain significance Single submitter
All CERK variants
Benign 3
- p.His113= Multiple submitters
- p.Pro509= Multiple submitters
- p.Thr461Met Multiple submitters
Likely benign 7
- p.Asn496Ser Single submitter
- p.Gly190= Single submitter
- p.Gly475Arg Single submitter
- p.Gly475Glu Single submitter
- p.Pro531Leu Single submitter
- p.Val262Ile Single submitter
- p.Val384Ile Single submitter
Uncertain significance 100
- p.Ala215Thr Single submitter ⚠
- p.Ala215Val Single submitter ⚠
- p.Ala238Ser Single submitter ⚠
- p.Ala238Thr Single submitter ⚠
- p.Ala254Thr Single submitter ⚠
- p.Ala258Val Single submitter ⚠
- p.Ala28Glu Single submitter ⚠
- p.Ala374Thr Single submitter ⚠
- p.Ala393Gly Single submitter ⚠
- p.Ala44Gly Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg120Trp Single submitter ⚠
- p.Arg148Gln Single submitter ⚠
- p.Arg223Gln Single submitter ⚠
- p.Arg223Trp Single submitter ⚠
- p.Arg232Leu Single submitter ⚠
- p.Arg232Trp Single submitter ⚠
- p.Arg282Cys Single submitter ⚠
- p.Arg282His Single submitter ⚠
- p.Arg29Pro Single submitter ⚠
- p.Arg348Trp Single submitter ⚠
- p.Arg401Cys Single submitter ⚠
- p.Arg402Gln Single submitter ⚠
- p.Arg402Trp Single submitter ⚠
- p.Arg424Gln Single submitter ⚠
- p.Arg454Cys Single submitter ⚠
- p.Arg454His Single submitter ⚠
- p.Arg479His Single submitter ⚠
- p.Arg94Gln Single submitter ⚠
- p.Arg94Trp Single submitter ⚠
- p.Arg96Cys Single submitter ⚠
- p.Arg96His Single submitter ⚠
- p.Asp189Asn Single submitter ⚠
- p.Asp189His Single submitter ⚠
- p.Asp189Tyr Single submitter ⚠
- p.Asp218Asn Single submitter ⚠
- p.Asp253Asn Single submitter ⚠
- p.Asp343Tyr Single submitter ⚠
- p.Cys106Tyr Single submitter ⚠
- p.Cys484Tyr Single submitter ⚠
- p.Gln117His Single submitter ⚠
- p.Gln76Arg Single submitter ⚠
- p.Glu109Lys Single submitter ⚠
- p.Glu121Lys Single submitter ⚠
- p.Glu255Asp Single submitter ⚠
- p.Glu26Lys Single submitter ⚠
- p.Glu362Asp Single submitter ⚠
- p.Glu364Gly Single submitter ⚠
- p.Glu8Asp Single submitter ⚠
- p.Gly146Ser Single submitter ⚠
- p.Gly196Arg Single submitter ⚠
- p.Gly206Ser Single submitter ⚠
- p.Gly216Arg Single submitter ⚠
- p.Gly294Arg Single submitter ⚠
- p.Gly475Val Single submitter ⚠
- p.Gly503Glu Single submitter ⚠
- p.Gly5Arg Single submitter ⚠
- p.Gly67Arg Single submitter ⚠
- p.Gly67Glu Single submitter ⚠
- p.Ile163Val Single submitter ⚠
- p.Ile185Val Single submitter ⚠
- p.Ile191Phe Single submitter ⚠
- p.Ile296Asn Single submitter ⚠
- p.Ile483Val Single submitter ⚠
- p.Leu25Val Single submitter ⚠
- p.Leu267Met Single submitter ⚠
- p.Leu407Val Single submitter ⚠
- p.Leu472Phe Single submitter ⚠
- p.Lys477Arg Single submitter ⚠
- p.Met199Ile Single submitter ⚠
- p.Met465Leu Single submitter ⚠
- p.Met78Leu Single submitter ⚠
- p.Phe136Ser Single submitter ⚠
- p.Phe447Leu Single submitter ⚠
- p.Pro139Leu Single submitter ⚠
- p.Pro409Leu Single submitter ⚠
- p.Pro45Ser Single submitter ⚠
- p.Ser201Asn Single submitter ⚠
- p.Ser278Arg Single submitter ⚠
- p.Ser321Phe Single submitter ⚠
- p.Ser321Pro Single submitter ⚠
- p.Ser462Leu Single submitter ⚠
- p.Ser489Cys Single submitter ⚠
- p.Thr337Met Single submitter ⚠
- p.Thr4Ser Single submitter ⚠
- p.Trp99Gly Single submitter ⚠
- p.Tyr453Asp Single submitter ⚠
- p.Val169Gly Single submitter ⚠
- p.Val192Ile Single submitter ⚠
- p.Val262Ala Single submitter ⚠
- p.Val384Ala Single submitter ⚠
- p.Val384Phe Single submitter ⚠
- p.Val494Ile Single submitter ⚠
- p.Val513Ile Single submitter ⚠
- p.Val513Phe Single submitter ⚠
- p.Val54Leu Single submitter ⚠
- p.Val65Ile Single submitter ⚠
- p.Val89Ala Single submitter ⚠