CERS4 — 84 ClinVar variants
All ClinVar germline CERS4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
1 Benign · 5 Likely benign · 78 Uncertain significance
Full CERS4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CERS4 p.Ala162Val Uncertain significance Single submitter
- CERS4 p.Ala373Thr Uncertain significance Single submitter
- CERS4 p.Arg116Gln Uncertain significance Single submitter
- CERS4 p.Arg121His Uncertain significance Single submitter
- CERS4 p.Arg203Cys Uncertain significance Single submitter
- CERS4 p.Arg230Cys Uncertain significance Single submitter
- CERS4 p.Arg28Gln Uncertain significance Single submitter
- CERS4 p.Arg31Cys Uncertain significance Single submitter
- CERS4 p.Arg31His Uncertain significance Single submitter
- CERS4 p.Arg31Ser Uncertain significance Single submitter
- CERS4 p.Arg341Cys Uncertain significance Single submitter
- CERS4 p.Arg381Gln Uncertain significance Single submitter
- CERS4 p.Arg381Trp Uncertain significance Single submitter
- CERS4 p.Arg385Cys Uncertain significance Single submitter
- CERS4 p.Arg385Gly Uncertain significance Single submitter
- CERS4 p.Arg385His Uncertain significance Single submitter
- CERS4 p.Arg66Gln Uncertain significance Single submitter
- CERS4 p.Arg71Lys Uncertain significance Single submitter
- CERS4 p.Asn253Ser Uncertain significance Single submitter
- CERS4 p.Asn364His Uncertain significance Single submitter
- CERS4 p.Asp240Asn Uncertain significance Single submitter
- CERS4 p.Asp262Asn Uncertain significance Single submitter
- CERS4 p.Asp376Ala Uncertain significance Single submitter
- CERS4 p.Gln256Glu Uncertain significance Single submitter
- CERS4 p.Gln357Arg Uncertain significance Single submitter
- CERS4 p.Glu247Lys Uncertain significance Single submitter
- CERS4 p.Glu352Ala Uncertain significance Single submitter
- CERS4 p.Glu7Lys Uncertain significance Single submitter
- CERS4 p.Gly149Ser Uncertain significance Single submitter
- CERS4 p.Gly365Arg Uncertain significance Single submitter
- CERS4 p.Gly368Glu Uncertain significance Single submitter
- CERS4 p.Gly384Arg Uncertain significance Single submitter
- CERS4 p.His213Tyr Uncertain significance Single submitter
- CERS4 p.His35Arg Uncertain significance Single submitter
- CERS4 p.Ile293Met Uncertain significance Single submitter
- CERS4 p.Ile60Thr Uncertain significance Single submitter
- CERS4 p.Leu144Pro Uncertain significance Single submitter
- CERS4 p.Leu175Arg Uncertain significance Single submitter
- CERS4 p.Leu184Val Uncertain significance Single submitter
- CERS4 p.Leu277Arg Uncertain significance Single submitter
- CERS4 p.Leu49Phe Uncertain significance Single submitter
- CERS4 p.Leu64Met Uncertain significance Single submitter
- CERS4 p.Leu64Val Uncertain significance Single submitter
- CERS4 p.Lys131Arg Uncertain significance Single submitter
- CERS4 p.Lys332Arg Uncertain significance Single submitter
- CERS4 p.Lys338Glu Uncertain significance Single submitter
- CERS4 p.Lys363Asn Uncertain significance Single submitter
- CERS4 p.Met255Val Uncertain significance Single submitter
- CERS4 p.Met331Lys Uncertain significance Single submitter
- CERS4 p.Phe206Leu Uncertain significance Single submitter
- CERS4 p.Phe206Ser Uncertain significance Single submitter
- CERS4 p.Phe304Ser Uncertain significance Single submitter
- CERS4 p.Phe59Ile Uncertain significance Single submitter
- CERS4 p.Pro163Leu Uncertain significance Single submitter
- CERS4 p.Pro177Arg Uncertain significance Single submitter
- CERS4 p.Pro36Ser Uncertain significance Single submitter
- CERS4 p.Pro378Ser Uncertain significance Single submitter
- CERS4 p.Ser350Asn Uncertain significance Single submitter
- CERS4 p.Thr130Pro Uncertain significance Single submitter
- CERS4 p.Thr174Ile Uncertain significance Single submitter
- CERS4 p.Thr21Arg Uncertain significance Single submitter
- CERS4 p.Thr90Met Uncertain significance Single submitter
- CERS4 p.Trp159Arg Uncertain significance Single submitter
- CERS4 p.Tyr33His Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CERS4 p.Ala46Val Uncertain significance Single submitter
- CERS4 p.Arg28Trp Uncertain significance Single submitter
- CERS4 p.Arg66Trp Uncertain significance Single submitter
- CERS4 p.Gln209His Uncertain significance Single submitter
- CERS4 p.Glu208Val Uncertain significance Single submitter
- CERS4 p.Ile231Thr Uncertain significance Single submitter
- CERS4 p.Leu327Arg Uncertain significance Single submitter
- CERS4 p.Phe273Ser Uncertain significance Single submitter
- CERS4 p.Pro198Arg Uncertain significance Single submitter
- CERS4 p.Thr110Met Uncertain significance Single submitter
- CERS4 p.Val70Gly Uncertain significance Single submitter
All CERS4 variants
Benign 1
- p.Leu194= Multiple submitters
Likely benign 5
- p.Ala82Thr Multiple submitters
- c.520-5T>A Single submitter
- p.Glu351Asp Single submitter
- p.Leu362= Single submitter
- p.Pro44= Single submitter
Uncertain significance 78
- p.Ala162Val Single submitter ⚠
- p.Ala373Thr Single submitter ⚠
- p.Ala46Val Single submitter ⚠
- p.Arg116Gln Single submitter ⚠
- p.Arg121His Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg230Cys Single submitter ⚠
- p.Arg28Gln Single submitter ⚠
- p.Arg28Trp Single submitter ⚠
- p.Arg31Cys Single submitter ⚠
- p.Arg31His Single submitter ⚠
- p.Arg31Ser Single submitter ⚠
- p.Arg341Cys Single submitter ⚠
- p.Arg381Gln Single submitter ⚠
- p.Arg381Trp Single submitter ⚠
- p.Arg385Cys Single submitter ⚠
- p.Arg385Gly Single submitter ⚠
- p.Arg385His Single submitter ⚠
- p.Arg66Gln Single submitter ⚠
- p.Arg66Pro Single submitter
- p.Arg66Trp Single submitter ⚠
- p.Arg71Lys Single submitter ⚠
- p.Asn253Ser Single submitter ⚠
- p.Asn364His Single submitter ⚠
- p.Asp240Asn Single submitter ⚠
- p.Asp262Asn Single submitter ⚠
- p.Asp376Ala Single submitter ⚠
- p.Gln209His Single submitter ⚠
- p.Gln256Glu Single submitter ⚠
- p.Gln357Arg Single submitter ⚠
- p.Glu208Val Single submitter ⚠
- p.Glu247Lys Single submitter ⚠
- p.Glu352Ala Single submitter ⚠
- p.Glu7Lys Single submitter ⚠
- p.Gly149Ser Single submitter ⚠
- p.Gly365Arg Single submitter ⚠
- p.Gly368Glu Single submitter ⚠
- p.Gly384Arg Single submitter ⚠
- p.His213Tyr Single submitter ⚠
- p.His35Arg Single submitter ⚠
- p.Ile231Thr Single submitter ⚠
- p.Ile293Met Single submitter ⚠
- p.Ile60Thr Single submitter ⚠
- p.Leu144Pro Single submitter ⚠
- p.Leu175Arg Single submitter ⚠
- p.Leu184Val Single submitter ⚠
- p.Leu277Arg Single submitter ⚠
- p.Leu327Arg Single submitter ⚠
- p.Leu40Ser Single submitter
- p.Leu49Phe Single submitter ⚠
- p.Leu64Met Single submitter ⚠
- p.Leu64Val Single submitter ⚠
- p.Lys131Arg Single submitter ⚠
- p.Lys332Arg Single submitter ⚠
- p.Lys338Glu Single submitter ⚠
- p.Lys363Asn Single submitter ⚠
- p.Met255Val Single submitter ⚠
- p.Met331Lys Single submitter ⚠
- p.Phe206Leu Single submitter ⚠
- p.Phe206Ser Single submitter ⚠
- p.Phe273Ser Single submitter ⚠
- p.Phe304Ser Single submitter ⚠
- p.Phe59Ile Single submitter ⚠
- p.Pro163Leu Single submitter ⚠
- p.Pro177Arg Single submitter ⚠
- p.Pro198Arg Single submitter ⚠
- p.Pro36Ser Single submitter ⚠
- p.Pro378Ser Single submitter ⚠
- p.Ser350Asn Single submitter ⚠
- p.Thr110Met Single submitter ⚠
- p.Thr130Pro Single submitter ⚠
- p.Thr174Ile Single submitter ⚠
- p.Thr21Arg Single submitter ⚠
- p.Thr90Met Single submitter ⚠
- p.Trp159Arg Single submitter ⚠
- p.Tyr33Asn Single submitter
- p.Tyr33His Single submitter ⚠
- p.Val70Gly Single submitter ⚠