CERS5 — 56 ClinVar variants
All ClinVar germline CERS5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
1 Likely benign · 55 Uncertain significance
Full CERS5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CERS5 p.Ala278Val Uncertain significance Single submitter
- CERS5 p.Ala377Thr Uncertain significance Single submitter
- CERS5 p.Arg284Gln Uncertain significance Single submitter
- CERS5 p.Arg349Cys Uncertain significance Single submitter
- CERS5 p.Arg45Gln Uncertain significance Single submitter
- CERS5 p.Arg45Trp Uncertain significance Single submitter
- CERS5 p.Cys72Phe Uncertain significance Single submitter
- CERS5 p.Gln6Leu Uncertain significance Single submitter
- CERS5 p.Glu392Gln Uncertain significance Single submitter
- CERS5 p.Glu79Asp Uncertain significance Single submitter
- CERS5 p.Glu79Lys Uncertain significance Single submitter
- CERS5 p.Gly110Val Uncertain significance Single submitter
- CERS5 p.Gly34Glu Uncertain significance Single submitter
- CERS5 p.His176Arg Uncertain significance Single submitter
- CERS5 p.Ile225Asn Uncertain significance Single submitter
- CERS5 p.Ile47Val Uncertain significance Single submitter
- CERS5 p.Ile97Leu Uncertain significance Single submitter
- CERS5 p.Ser231Phe Uncertain significance Single submitter
- CERS5 p.Ser300Ile Uncertain significance Single submitter
- CERS5 p.Ser350Thr Uncertain significance Single submitter
- CERS5 p.Trp169Cys Uncertain significance Single submitter
- CERS5 p.Trp301Cys Uncertain significance Single submitter
- CERS5 p.Tyr232His Uncertain significance Single submitter
- CERS5 p.Tyr388His Uncertain significance Single submitter
- CERS5 p.Tyr39Phe Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- CERS5 p.Ala2Thr Uncertain significance Single submitter
- CERS5 p.Ala338Ser Uncertain significance Single submitter
- CERS5 p.Arg127His Uncertain significance Single submitter
- CERS5 p.Arg238Gln Uncertain significance Single submitter
- CERS5 p.Arg267Gln Uncertain significance Single submitter
- CERS5 p.Asn235His Uncertain significance Single submitter
- CERS5 p.Asn314Ser Uncertain significance Single submitter
- CERS5 p.Gln132Lys Uncertain significance Single submitter
- CERS5 p.Gln205His Uncertain significance Single submitter
- CERS5 p.Glu25Asp Uncertain significance Single submitter
- CERS5 p.Gly305Arg Uncertain significance Single submitter
- CERS5 p.Gly376Ala Uncertain significance Single submitter
- CERS5 p.Gly38Asp Uncertain significance Single submitter
- CERS5 p.Ile122Leu Uncertain significance Single submitter
- CERS5 p.Ile228Met Uncertain significance Single submitter
- CERS5 p.Ile233Leu Uncertain significance Single submitter
- CERS5 p.Leu115Met Uncertain significance Single submitter
- CERS5 p.Leu12Pro Uncertain significance Single submitter
- CERS5 p.Leu272Phe Uncertain significance Single submitter
- CERS5 p.Leu32Val Uncertain significance Single submitter
- CERS5 p.Leu9Pro Uncertain significance Single submitter
- CERS5 p.Lys264Asn Uncertain significance Single submitter
- CERS5 p.Lys94Asn Uncertain significance Single submitter
- CERS5 p.Phe155Cys Uncertain significance Single submitter
- CERS5 p.Phe67Leu Uncertain significance Single submitter
- CERS5 p.Ser49Pro Uncertain significance Single submitter
- CERS5 p.Thr137Ala Uncertain significance Single submitter
- CERS5 p.Thr295Met Uncertain significance Single submitter
- CERS5 p.Trp199Ser Uncertain significance Single submitter
- CERS5 p.Val344Ala Uncertain significance Single submitter
All CERS5 variants
Likely benign 1
- p.Thr319Ile Single submitter
Uncertain significance 55
- p.Ala278Val Single submitter ⚠
- p.Ala2Thr Single submitter ⚠
- p.Ala338Ser Single submitter ⚠
- p.Ala377Thr Single submitter ⚠
- p.Arg127His Single submitter ⚠
- p.Arg238Gln Single submitter ⚠
- p.Arg267Gln Single submitter ⚠
- p.Arg284Gln Single submitter ⚠
- p.Arg349Cys Single submitter ⚠
- p.Arg45Gln Single submitter ⚠
- p.Arg45Trp Single submitter ⚠
- p.Asn235His Single submitter ⚠
- p.Asn314Ser Single submitter ⚠
- p.Cys72Phe Single submitter ⚠
- p.Gln132Lys Single submitter ⚠
- p.Gln205His Single submitter ⚠
- p.Gln6Leu Single submitter ⚠
- p.Glu25Asp Single submitter ⚠
- p.Glu392Gln Single submitter ⚠
- p.Glu79Asp Single submitter ⚠
- p.Glu79Lys Single submitter ⚠
- p.Gly110Val Single submitter ⚠
- p.Gly305Arg Single submitter ⚠
- p.Gly34Glu Single submitter ⚠
- p.Gly376Ala Single submitter ⚠
- p.Gly38Asp Single submitter ⚠
- p.His176Arg Single submitter ⚠
- p.Ile122Leu Single submitter ⚠
- p.Ile225Asn Single submitter ⚠
- p.Ile228Met Single submitter ⚠
- p.Ile233Leu Single submitter ⚠
- p.Ile47Val Single submitter ⚠
- p.Ile97Leu Single submitter ⚠
- p.Leu115Met Single submitter ⚠
- p.Leu12Pro Single submitter ⚠
- p.Leu272Phe Single submitter ⚠
- p.Leu32Val Single submitter ⚠
- p.Leu9Pro Single submitter ⚠
- p.Lys264Asn Single submitter ⚠
- p.Lys94Asn Single submitter ⚠
- p.Phe155Cys Single submitter ⚠
- p.Phe67Leu Single submitter ⚠
- p.Ser231Phe Single submitter ⚠
- p.Ser300Ile Single submitter ⚠
- p.Ser350Thr Single submitter ⚠
- p.Ser49Pro Single submitter ⚠
- p.Thr137Ala Single submitter ⚠
- p.Thr295Met Single submitter ⚠
- p.Trp169Cys Single submitter ⚠
- p.Trp199Ser Single submitter ⚠
- p.Trp301Cys Single submitter ⚠
- p.Tyr232His Single submitter ⚠
- p.Tyr388His Single submitter ⚠
- p.Tyr39Phe Single submitter ⚠
- p.Val344Ala Single submitter ⚠