CERS6 — 44 ClinVar variants
All ClinVar germline CERS6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
2 Benign · 5 Likely benign · 37 Uncertain significance
Full CERS6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CERS6 p.Ala30Ser Uncertain significance Single submitter
- CERS6 p.Ala326Val Uncertain significance Single submitter
- CERS6 p.Ala362Val Uncertain significance Single submitter
- CERS6 p.Arg121Cys Uncertain significance Single submitter
- CERS6 p.Asn168Lys Uncertain significance Single submitter
- CERS6 p.Cys380Arg Uncertain significance Single submitter
- CERS6 p.Gly3Ala Uncertain significance Single submitter
- CERS6 p.His17Arg Uncertain significance Single submitter
- CERS6 p.Ile200Val Uncertain significance Single submitter
- CERS6 p.Ile54Val Uncertain significance Single submitter
- CERS6 p.Leu143Phe Uncertain significance Single submitter
- CERS6 p.Leu213Val Uncertain significance Single submitter
- CERS6 p.Phe146Leu Uncertain significance Single submitter
- CERS6 p.Pro355Ala Uncertain significance Single submitter
- CERS6 p.Pro62Arg Uncertain significance Single submitter
- CERS6 p.Pro62Ser Uncertain significance Single submitter
- CERS6 p.Ser331Ala Uncertain significance Single submitter
- CERS6 p.Thr176Ala Uncertain significance Single submitter
- CERS6 p.Thr274Pro Uncertain significance Single submitter
- CERS6 p.Tyr374Cys Uncertain significance Single submitter
- CERS6 p.Val295Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CERS6 p.Ala6Val Uncertain significance Single submitter
- CERS6 p.Asn10Lys Uncertain significance Single submitter
- CERS6 p.Asn122Ser Uncertain significance Single submitter
- CERS6 p.Asn18Ser Uncertain significance Single submitter
- CERS6 p.Asn366Ser Uncertain significance Single submitter
- CERS6 p.Asn80Ser Uncertain significance Single submitter
- CERS6 p.Gln119Glu Uncertain significance Single submitter
- CERS6 p.Gly206Val Uncertain significance Single submitter
- CERS6 p.Leu5Phe Uncertain significance Single submitter
- CERS6 p.Lys61Glu Uncertain significance Single submitter
- CERS6 p.Pro78Leu Uncertain significance Single submitter
- CERS6 p.Thr128Met Uncertain significance Single submitter
- CERS6 p.Thr162Met Uncertain significance Single submitter
- CERS6 p.Thr365Pro Uncertain significance Single submitter
- CERS6 p.Tyr167Cys Uncertain significance Single submitter
- CERS6 p.Tyr39Cys Uncertain significance Single submitter
- CERS6 p.Val269Met Likely benign Single submitter
All CERS6 variants
Benign 2
- p.Gly206= Single submitter
- p.Leu237Val Single submitter
Likely benign 5
- p.Arg57= Single submitter
- p.Asn72Ser Single submitter
- p.Ile207Val Single submitter
- p.Leu306= Single submitter
- p.Val269Met Single submitter ⚠
Uncertain significance 37
- p.Ala30Ser Single submitter ⚠
- p.Ala326Val Single submitter ⚠
- p.Ala362Val Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Arg121Cys Single submitter ⚠
- p.Asn10Lys Single submitter ⚠
- p.Asn122Ser Single submitter ⚠
- p.Asn168Lys Single submitter ⚠
- p.Asn18Ser Single submitter ⚠
- p.Asn366Ser Single submitter ⚠
- p.Asn80Ser Single submitter ⚠
- p.Cys380Arg Single submitter ⚠
- p.Gln119Glu Single submitter ⚠
- p.Gly206Val Single submitter ⚠
- p.Gly3Ala Single submitter ⚠
- p.His17Arg Single submitter ⚠
- p.Ile200Val Single submitter ⚠
- p.Ile54Val Single submitter ⚠
- p.Leu143Phe Single submitter ⚠
- p.Leu213Val Single submitter ⚠
- p.Leu5Phe Single submitter ⚠
- p.Lys61Glu Single submitter ⚠
- p.Phe146Leu Single submitter ⚠
- p.Pro355Ala Single submitter ⚠
- p.Pro62Arg Single submitter ⚠
- p.Pro62Ser Single submitter ⚠
- p.Pro78Leu Single submitter ⚠
- p.Ser331Ala Single submitter ⚠
- p.Thr128Met Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Thr176Ala Single submitter ⚠
- p.Thr274Pro Single submitter ⚠
- p.Thr365Pro Single submitter ⚠
- p.Tyr167Cys Single submitter ⚠
- p.Tyr374Cys Single submitter ⚠
- p.Tyr39Cys Single submitter ⚠
- p.Val295Ile Single submitter ⚠