CES2 — 72 ClinVar variants
All ClinVar germline CES2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
1 Benign · 7 Likely benign · 64 Uncertain significance
Full CES2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CES2 p.Ala132Val Uncertain significance Single submitter
- CES2 p.Ala405Val Uncertain significance Single submitter
- CES2 p.Ala541Val Uncertain significance Single submitter
- CES2 p.Ala8Glu Uncertain significance Single submitter
- CES2 p.Arg178Cys Uncertain significance Single submitter
- CES2 p.Arg221His Uncertain significance Single submitter
- CES2 p.Arg430Trp Uncertain significance Single submitter
- CES2 p.Arg7Cys Uncertain significance Single submitter
- CES2 p.Asn195Lys Uncertain significance Single submitter
- CES2 p.Asn218Ser Uncertain significance Single submitter
- CES2 p.Asp117Asn Uncertain significance Single submitter
- CES2 p.Asp200Gly Uncertain significance Single submitter
- CES2 p.Asp512Asn Uncertain significance Single submitter
- CES2 p.Cys95Tyr Uncertain significance Single submitter
- CES2 p.Gly148Arg Uncertain significance Single submitter
- CES2 p.Gly347Ser Uncertain significance Single submitter
- CES2 p.His425Tyr Uncertain significance Single submitter
- CES2 p.Ile242Thr Uncertain significance Single submitter
- CES2 p.Ile448Thr Uncertain significance Single submitter
- CES2 p.Ile474Thr Uncertain significance Single submitter
- CES2 p.Leu151Phe Uncertain significance Single submitter
- CES2 p.Met354Ile Uncertain significance Single submitter
- CES2 p.Met380Thr Uncertain significance Single submitter
- CES2 p.Met415Val Uncertain significance Single submitter
- CES2 p.Pro92Arg Uncertain significance Single submitter
- CES2 p.Ser368Cys Uncertain significance Single submitter
- CES2 p.Ser414Cys Uncertain significance Single submitter
- CES2 p.Thr232Met Uncertain significance Single submitter
- CES2 p.Thr557Ala Uncertain significance Single submitter
- CES2 p.Val238Ile Uncertain significance Single submitter
- CES2 p.Val269Ala Uncertain significance Single submitter
- CES2 p.Val269Phe Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CES2 p.Ala192Thr Uncertain significance Single submitter
- CES2 p.Ala213Pro Uncertain significance Single submitter
- CES2 p.Ala213Thr Uncertain significance Single submitter
- CES2 p.Ala532Asp Uncertain significance Single submitter
- CES2 p.Asn276Ile Uncertain significance Single submitter
- CES2 p.Asn343Lys Uncertain significance Single submitter
- CES2 p.Asn447Ile Uncertain significance Single submitter
- CES2 p.Asn501Ser Uncertain significance Single submitter
- CES2 p.Glu437Lys Uncertain significance Single submitter
- CES2 p.Glu77Ala Uncertain significance Single submitter
- CES2 p.Gly504Val Uncertain significance Single submitter
- CES2 p.Ile251Met Uncertain significance Single submitter
- CES2 p.Ile394Thr Uncertain significance Single submitter
- CES2 p.Leu262Arg Uncertain significance Single submitter
- CES2 p.Lys190Asn Uncertain significance Single submitter
- CES2 p.Met252Thr Uncertain significance Single submitter
- CES2 p.Met488Lys Uncertain significance Single submitter
- CES2 p.Pro141Ala Uncertain significance Single submitter
- CES2 p.Pro70Leu Likely benign Single submitter
- CES2 p.Ser127Gly Uncertain significance Single submitter
- CES2 p.Thr89Ala Uncertain significance Single submitter
- CES2 p.Val170Met Uncertain significance Single submitter
- CES2 p.Val256Met Uncertain significance Single submitter
All CES2 variants
Benign 1
- p.Glu366= Multiple submitters
Likely benign 7
- c.-188C>G Single submitter
- p.Arg23Gln Single submitter
- p.Asn447Asp Single submitter
- p.Gly458= Single submitter
- p.His147= Single submitter
- p.Leu17= Single submitter
- p.Pro70Leu Single submitter ⚠
Uncertain significance 64
- c.-100G>T Single submitter
- c.-107C>T Single submitter
- c.-108A>T Single submitter
- c.-143G>A Single submitter
- c.-150G>C Single submitter
- c.-16G>T Single submitter
- c.-29G>A Single submitter
- c.-56C>T Single submitter
- c.-65C>T Single submitter
- c.-95G>A Single submitter
- p.Ala132Val Single submitter ⚠
- p.Ala192Thr Single submitter ⚠
- p.Ala213Pro Single submitter ⚠
- p.Ala213Thr Single submitter ⚠
- p.Ala405Val Single submitter ⚠
- p.Ala532Asp Single submitter ⚠
- p.Ala541Val Single submitter ⚠
- p.Ala8Glu Single submitter ⚠
- p.Arg178Cys Single submitter ⚠
- p.Arg221His Single submitter ⚠
- p.Arg430Trp Single submitter ⚠
- p.Arg7Cys Single submitter ⚠
- p.Asn195Lys Single submitter ⚠
- p.Asn218Ser Single submitter ⚠
- p.Asn276Ile Single submitter ⚠
- p.Asn343Lys Single submitter ⚠
- p.Asn447Ile Single submitter ⚠
- p.Asn501Ser Single submitter ⚠
- p.Asp117Asn Single submitter ⚠
- p.Asp200Gly Single submitter ⚠
- p.Asp512Asn Single submitter ⚠
- p.Cys95Tyr Single submitter ⚠
- p.Glu437Lys Single submitter ⚠
- p.Glu77Ala Single submitter ⚠
- p.Gly148Arg Single submitter ⚠
- p.Gly347Ser Single submitter ⚠
- p.Gly504Val Single submitter ⚠
- p.His425Tyr Single submitter ⚠
- p.Ile242Thr Single submitter ⚠
- p.Ile251Met Single submitter ⚠
- p.Ile394Thr Single submitter ⚠
- p.Ile448Thr Single submitter ⚠
- p.Ile474Thr Single submitter ⚠
- p.Leu151Phe Single submitter ⚠
- p.Leu262Arg Single submitter ⚠
- p.Lys190Asn Single submitter ⚠
- p.Met252Thr Single submitter ⚠
- p.Met354Ile Single submitter ⚠
- p.Met380Thr Single submitter ⚠
- p.Met415Val Single submitter ⚠
- p.Met488Lys Single submitter ⚠
- p.Pro141Ala Single submitter ⚠
- p.Pro92Arg Single submitter ⚠
- p.Ser127Gly Single submitter ⚠
- p.Ser368Cys Single submitter ⚠
- p.Ser414Cys Single submitter ⚠
- p.Thr232Met Single submitter ⚠
- p.Thr557Ala Single submitter ⚠
- p.Thr89Ala Single submitter ⚠
- p.Val170Met Single submitter ⚠
- p.Val238Ile Single submitter ⚠
- p.Val256Met Single submitter ⚠
- p.Val269Ala Single submitter ⚠
- p.Val269Phe Single submitter ⚠