CES3 — 91 ClinVar variants
All ClinVar germline CES3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →
10 Likely benign · 81 Uncertain significance
Full CES3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 86
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CES3 p.Ala230Gly Uncertain significance Single submitter
- CES3 p.Ala449Glu Uncertain significance Single submitter
- CES3 p.Arg179Cys Uncertain significance Single submitter
- CES3 p.Arg479His Uncertain significance Single submitter
- CES3 p.Arg534Gln Uncertain significance Single submitter
- CES3 p.Asn112Asp Uncertain significance Single submitter
- CES3 p.Asn128Lys Uncertain significance Single submitter
- CES3 p.Asn419Thr Uncertain significance Single submitter
- CES3 p.Asp369Glu Uncertain significance Single submitter
- CES3 p.Asp73Glu Uncertain significance Single submitter
- CES3 p.Cys97Gly Uncertain significance Single submitter
- CES3 p.Gln210Lys Uncertain significance Single submitter
- CES3 p.Gln499Pro Uncertain significance Single submitter
- CES3 p.Glu476Lys Uncertain significance Single submitter
- CES3 p.Gly169Glu Uncertain significance Single submitter
- CES3 p.Gly298Glu Uncertain significance Single submitter
- CES3 p.Gly469Arg Uncertain significance Single submitter
- CES3 p.Ile63Thr Uncertain significance Single submitter
- CES3 p.Ile63Val Uncertain significance Single submitter
- CES3 p.Leu328Ile Uncertain significance Single submitter
- CES3 p.Leu473Phe Uncertain significance Single submitter
- CES3 p.Met289Thr Uncertain significance Single submitter
- CES3 p.Met387Ile Uncertain significance Single submitter
- CES3 p.Met413Ile Uncertain significance Single submitter
- CES3 p.Pro509Arg Uncertain significance Single submitter
- CES3 p.Ser187Arg Uncertain significance Single submitter
- CES3 p.Ser266Pro Uncertain significance Single submitter
- CES3 p.Ser349Thr Uncertain significance Single submitter
- CES3 p.Thr422Ile Uncertain significance Single submitter
- CES3 p.Thr495Pro Uncertain significance Single submitter
- CES3 p.Tyr428His Uncertain significance Single submitter
- CES3 p.Val101Met Uncertain significance Single submitter
- CES3 p.Val377Ile Uncertain significance Single submitter
- CES3 p.Val7Met Uncertain significance Single submitter
Predictors split 52
The independent predictors disagree with each other — read with care.
- CES3 p.Ala133Pro Uncertain significance Single submitter
- CES3 p.Ala137Thr Uncertain significance Single submitter
- CES3 p.Ala214Thr Likely benign Single submitter
- CES3 p.Ala214Val Uncertain significance Single submitter
- CES3 p.Ala244Thr Uncertain significance Single submitter
- CES3 p.Ala408Glu Uncertain significance Single submitter
- CES3 p.Ala449Val Uncertain significance Single submitter
- CES3 p.Ala481Asp Uncertain significance Single submitter
- CES3 p.Ala481Val Uncertain significance Single submitter
- CES3 p.Ala81Ser Uncertain significance Single submitter
- CES3 p.Arg207Cys Uncertain significance Single submitter
- CES3 p.Arg430Gln Likely benign Single submitter
- CES3 p.Arg44Gln Uncertain significance Single submitter
- CES3 p.Arg74Trp Uncertain significance Single submitter
- CES3 p.Arg88Gln Uncertain significance Single submitter
- CES3 p.Asn521Ile Uncertain significance Single submitter
- CES3 p.Asp170Asn Uncertain significance Single submitter
- CES3 p.Asp265Gly Uncertain significance Single submitter
- CES3 p.Asp369Gly Uncertain significance Single submitter
- CES3 p.Asp37Tyr Uncertain significance Single submitter
- CES3 p.Asp570His Uncertain significance Single submitter
- CES3 p.Gln525His Uncertain significance Single submitter
- CES3 p.Glu30Lys Likely benign Single submitter
- CES3 p.Glu394Gly Uncertain significance Single submitter
- CES3 p.Gly113Arg Uncertain significance Single submitter
- CES3 p.Gly218Ser Uncertain significance Single submitter
- CES3 p.Gly298Arg Uncertain significance Single submitter
- CES3 p.Gly71Asp Uncertain significance Single submitter
- CES3 p.Ile529Val Uncertain significance Single submitter
- CES3 p.Leu473His Uncertain significance Single submitter
- CES3 p.Leu551Phe Uncertain significance Single submitter
- CES3 p.Met413Thr Uncertain significance Single submitter
- CES3 p.Phe438Ser Uncertain significance Single submitter
- CES3 p.Phe448Leu Uncertain significance Single submitter
- CES3 p.Phe539Leu Likely benign Single submitter
- CES3 p.Pro142Leu Uncertain significance Single submitter
- CES3 p.Pro325Ser Uncertain significance Single submitter
- CES3 p.Pro64Gln Uncertain significance Single submitter
- CES3 p.Pro68Leu Uncertain significance Single submitter
- CES3 p.Thr319Ser Uncertain significance Single submitter
- CES3 p.Thr506Ala Uncertain significance Single submitter
- CES3 p.Thr550Met Uncertain significance Single submitter
- CES3 p.Tyr439Cys Uncertain significance Single submitter
- CES3 p.Val173Ala Uncertain significance Single submitter
- CES3 p.Val173Met Uncertain significance Single submitter
- CES3 p.Val203Glu Uncertain significance Single submitter
- CES3 p.Val257Ile Uncertain significance Single submitter
- CES3 p.Val316Ile Likely benign Single submitter
- CES3 p.Val31Ile Uncertain significance Single submitter
- CES3 p.Val383Met Uncertain significance Single submitter
- CES3 p.Val456Leu Uncertain significance Single submitter
- CES3 p.Val456Met Uncertain significance Single submitter
All CES3 variants
Likely benign 10
- p.Ala214Thr Single submitter ⚠
- p.Ala535Val Single submitter
- p.Arg179His Single submitter
- p.Arg430Gln Single submitter ⚠
- p.Glu30Lys Single submitter ⚠
- p.Gly536Arg Single submitter
- p.Phe539Leu Single submitter ⚠
- p.Val120Ile Single submitter
- p.Val147Ile Single submitter
- p.Val316Ile Single submitter ⚠
Uncertain significance 81
- p.Ala133Pro Single submitter ⚠
- p.Ala137Thr Single submitter ⚠
- p.Ala214Val Single submitter ⚠
- p.Ala230Gly Single submitter ⚠
- p.Ala244Thr Single submitter ⚠
- p.Ala408Glu Single submitter ⚠
- p.Ala449Glu Single submitter ⚠
- p.Ala449Val Single submitter ⚠
- p.Ala481Asp Single submitter ⚠
- p.Ala481Val Single submitter ⚠
- p.Ala81Ser Single submitter ⚠
- p.Arg179Cys Single submitter ⚠
- p.Arg207Cys Single submitter ⚠
- p.Arg44Gln Single submitter ⚠
- p.Arg479His Single submitter ⚠
- p.Arg534Gln Single submitter ⚠
- p.Arg74Trp Single submitter ⚠
- p.Arg88Gln Single submitter ⚠
- p.Asn112Asp Single submitter ⚠
- p.Asn128Lys Single submitter ⚠
- p.Asn419Thr Single submitter ⚠
- p.Asn521Ile Single submitter ⚠
- p.Asp170Asn Single submitter ⚠
- p.Asp265Gly Single submitter ⚠
- p.Asp369Glu Single submitter ⚠
- p.Asp369Gly Single submitter ⚠
- p.Asp37Tyr Single submitter ⚠
- p.Asp570His Single submitter ⚠
- p.Asp73Glu Single submitter ⚠
- p.Cys97Gly Single submitter ⚠
- p.Gln210Lys Single submitter ⚠
- p.Gln499Pro Single submitter ⚠
- p.Gln525His Single submitter ⚠
- p.Glu394Gly Single submitter ⚠
- p.Glu476Lys Single submitter ⚠
- p.Gly113Arg Single submitter ⚠
- p.Gly169Glu Single submitter ⚠
- p.Gly218Ser Single submitter ⚠
- p.Gly298Arg Single submitter ⚠
- p.Gly298Glu Single submitter ⚠
- p.Gly469Arg Single submitter ⚠
- p.Gly71Asp Single submitter ⚠
- p.Ile529Val Single submitter ⚠
- p.Ile63Thr Single submitter ⚠
- p.Ile63Val Single submitter ⚠
- p.Leu328Ile Single submitter ⚠
- p.Leu473His Single submitter ⚠
- p.Leu473Phe Single submitter ⚠
- p.Leu551Phe Single submitter ⚠
- p.Met289Thr Single submitter ⚠
- p.Met387Ile Single submitter ⚠
- p.Met413Ile Single submitter ⚠
- p.Met413Thr Single submitter ⚠
- p.Phe438Ser Single submitter ⚠
- p.Phe448Leu Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro325Ser Single submitter ⚠
- p.Pro509Arg Single submitter ⚠
- p.Pro64Gln Single submitter ⚠
- p.Pro68Leu Single submitter ⚠
- p.Ser187Arg Single submitter ⚠
- p.Ser266Pro Single submitter ⚠
- p.Ser349Thr Single submitter ⚠
- p.Thr319Ser Single submitter ⚠
- p.Thr422Ile Single submitter ⚠
- p.Thr495Pro Single submitter ⚠
- p.Thr506Ala Single submitter ⚠
- p.Thr550Met Single submitter ⚠
- p.Tyr428His Single submitter ⚠
- p.Tyr439Cys Single submitter ⚠
- p.Val101Met Single submitter ⚠
- p.Val173Ala Single submitter ⚠
- p.Val173Met Single submitter ⚠
- p.Val203Glu Single submitter ⚠
- p.Val257Ile Single submitter ⚠
- p.Val31Ile Single submitter ⚠
- p.Val377Ile Single submitter ⚠
- p.Val383Met Single submitter ⚠
- p.Val456Leu Single submitter ⚠
- p.Val456Met Single submitter ⚠
- p.Val7Met Single submitter ⚠