CETN2 — 9 ClinVar variants
All ClinVar germline CETN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
1 Likely benign · 8 Uncertain significance
Full CETN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
All CETN2 variants
Likely benign 1
- p.Ser158Asn Multiple submitters
Uncertain significance 8
- p.Arg164His Single submitter ⚠
- p.Asn136Ser Single submitter ⚠
- p.Asp49Glu Single submitter ⚠
- p.Glu132Gly Single submitter ⚠
- p.Lys70Arg Single submitter ⚠
- p.Met10Val Single submitter ⚠
- p.Met19Val Single submitter ⚠
- p.Val50Ile Single submitter ⚠