CFAP157 — 87 ClinVar variants
All ClinVar germline CFAP157 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
5 Likely benign · 82 Uncertain significance
Full CFAP157 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CFAP157 p.Ala121Val Uncertain significance Single submitter
- CFAP157 p.Ala420Glu Uncertain significance Single submitter
- CFAP157 p.Arg317Thr Uncertain significance Single submitter
- CFAP157 p.Arg382His Uncertain significance Single submitter
- CFAP157 p.Arg518Cys Uncertain significance Single submitter
- CFAP157 p.Arg51Leu Uncertain significance Single submitter
- CFAP157 p.Arg54Trp Uncertain significance Single submitter
- CFAP157 p.Arg57Gln Uncertain significance Single submitter
- CFAP157 p.Asn474Lys Uncertain significance Single submitter
- CFAP157 p.Asp181Val Uncertain significance Single submitter
- CFAP157 p.Asp195Asn Uncertain significance Single submitter
- CFAP157 p.Asp195Glu Uncertain significance Single submitter
- CFAP157 p.Asp461His Uncertain significance Single submitter
- CFAP157 p.Gln106His Uncertain significance Single submitter
- CFAP157 p.Gln203Arg Uncertain significance Single submitter
- CFAP157 p.Gln237Lys Uncertain significance Single submitter
- CFAP157 p.Gln326Glu Uncertain significance Single submitter
- CFAP157 p.Gln468Pro Uncertain significance Single submitter
- CFAP157 p.Glu103Lys Uncertain significance Single submitter
- CFAP157 p.Glu113Asp Uncertain significance Single submitter
- CFAP157 p.Glu140Gly Uncertain significance Single submitter
- CFAP157 p.Glu15Gln Uncertain significance Single submitter
- CFAP157 p.Glu170Lys Uncertain significance Single submitter
- CFAP157 p.Glu222Gln Uncertain significance Single submitter
- CFAP157 p.Glu296Ala Uncertain significance Single submitter
- CFAP157 p.Gly145Glu Uncertain significance Single submitter
- CFAP157 p.Gly145Val Uncertain significance Single submitter
- CFAP157 p.Gly488Glu Uncertain significance Single submitter
- CFAP157 p.Gly502Val Uncertain significance Single submitter
- CFAP157 p.Ile142Thr Uncertain significance Single submitter
- CFAP157 p.Ile286Asn Uncertain significance Single submitter
- CFAP157 p.Ile98Leu Uncertain significance Single submitter
- CFAP157 p.Leu105Pro Uncertain significance Single submitter
- CFAP157 p.Lys174Arg Uncertain significance Single submitter
- CFAP157 p.Lys23Glu Uncertain significance Single submitter
- CFAP157 p.Lys398Glu Uncertain significance Single submitter
- CFAP157 p.Lys4Glu Uncertain significance Single submitter
- CFAP157 p.Met246Arg Uncertain significance Single submitter
- CFAP157 p.Met380Thr Uncertain significance Single submitter
- CFAP157 p.Pro449Leu Uncertain significance Single submitter
- CFAP157 p.Ser446Pro Uncertain significance Single submitter
- CFAP157 p.Thr217Met Uncertain significance Single submitter
- CFAP157 p.Trp396Arg Uncertain significance Single submitter
- CFAP157 p.Val191Leu Uncertain significance Single submitter
- CFAP157 p.Val208Met Uncertain significance Single submitter
- CFAP157 p.Val241Phe Uncertain significance Single submitter
- CFAP157 p.Val323Met Uncertain significance Single submitter
- CFAP157 p.Val359Ile Uncertain significance Single submitter
- CFAP157 p.Val465Ile Uncertain significance Single submitter
- CFAP157 p.Val64Ala Uncertain significance Single submitter
- CFAP157 p.Val95Gly Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- CFAP157 p.Ala365Val Uncertain significance Single submitter
- CFAP157 p.Arg155Gln Uncertain significance Single submitter
- CFAP157 p.Arg155Trp Uncertain significance Single submitter
- CFAP157 p.Arg308His Uncertain significance Single submitter
- CFAP157 p.Arg348Trp Uncertain significance Single submitter
- CFAP157 p.Arg360Gln Uncertain significance Single submitter
- CFAP157 p.Arg436Trp Uncertain significance Single submitter
- CFAP157 p.Arg467Cys Uncertain significance Single submitter
- CFAP157 p.Arg486His Uncertain significance Single submitter
- CFAP157 p.Arg499Cys Uncertain significance Single submitter
- CFAP157 p.Arg70His Uncertain significance Single submitter
- CFAP157 p.Arg89Cys Uncertain significance Single submitter
- CFAP157 p.Asn325Tyr Uncertain significance Single submitter
- CFAP157 p.Gln326Arg Uncertain significance Single submitter
- CFAP157 p.Gln347His Uncertain significance Single submitter
- CFAP157 p.Glu120Gln Uncertain significance Single submitter
- CFAP157 p.Glu270Ala Uncertain significance Single submitter
- CFAP157 p.Glu66Val Uncertain significance Single submitter
- CFAP157 p.Leu507Phe Likely benign Single submitter
- CFAP157 p.Lys112Thr Uncertain significance Single submitter
- CFAP157 p.Lys147Arg Uncertain significance Single submitter
- CFAP157 p.Lys147Asn Uncertain significance Single submitter
- CFAP157 p.Lys174Met Uncertain significance Single submitter
- CFAP157 p.Lys4Gln Uncertain significance Single submitter
- CFAP157 p.Met289Ile Uncertain significance Single submitter
- CFAP157 p.Pro3Ser Uncertain significance Single submitter
- CFAP157 p.Thr139Met Uncertain significance Single submitter
- CFAP157 p.Thr392Met Uncertain significance Single submitter
- CFAP157 p.Thr411Pro Uncertain significance Single submitter
- CFAP157 p.Thr414Met Uncertain significance Single submitter
- CFAP157 p.Val126Ala Uncertain significance Single submitter
- CFAP157 p.Val29Met Likely benign Single submitter
- CFAP157 p.Val391Met Uncertain significance Single submitter
All CFAP157 variants
Likely benign 5
- p.Arg219Gln Single submitter
- p.Arg240Lys Single submitter
- p.Arg491Gln Single submitter
- p.Leu507Phe Single submitter ⚠
- p.Val29Met Single submitter ⚠
Uncertain significance 82
- p.Ala121Val Single submitter ⚠
- p.Ala365Val Single submitter ⚠
- p.Ala420Glu Single submitter ⚠
- p.Arg155Gln Single submitter ⚠
- p.Arg155Trp Single submitter ⚠
- p.Arg308His Single submitter ⚠
- p.Arg317Thr Single submitter ⚠
- p.Arg348Trp Single submitter ⚠
- p.Arg360Gln Single submitter ⚠
- p.Arg382His Single submitter ⚠
- p.Arg436Trp Single submitter ⚠
- p.Arg467Cys Single submitter ⚠
- p.Arg486His Single submitter ⚠
- p.Arg499Cys Single submitter ⚠
- p.Arg518Cys Single submitter ⚠
- p.Arg51Leu Single submitter ⚠
- p.Arg54Trp Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg70His Single submitter ⚠
- p.Arg89Cys Single submitter ⚠
- p.Asn325Tyr Single submitter ⚠
- p.Asn474Lys Single submitter ⚠
- p.Asp181Val Single submitter ⚠
- p.Asp195Asn Single submitter ⚠
- p.Asp195Glu Single submitter ⚠
- p.Asp461His Single submitter ⚠
- p.Gln106His Single submitter ⚠
- p.Gln203Arg Single submitter ⚠
- p.Gln237Lys Single submitter ⚠
- p.Gln326Arg Single submitter ⚠
- p.Gln326Glu Single submitter ⚠
- p.Gln347His Single submitter ⚠
- p.Gln468Pro Single submitter ⚠
- p.Glu103Lys Single submitter ⚠
- p.Glu113Asp Single submitter ⚠
- p.Glu120Gln Single submitter ⚠
- p.Glu140Gly Single submitter ⚠
- p.Glu15Gln Single submitter ⚠
- p.Glu170Lys Single submitter ⚠
- p.Glu222Gln Single submitter ⚠
- p.Glu270Ala Single submitter ⚠
- p.Glu296Ala Single submitter ⚠
- p.Glu66Val Single submitter ⚠
- p.Gly145Glu Single submitter ⚠
- p.Gly145Val Single submitter ⚠
- p.Gly488Glu Single submitter ⚠
- p.Gly502Val Single submitter ⚠
- p.Ile142Thr Single submitter ⚠
- p.Ile286Asn Single submitter ⚠
- p.Ile98Leu Single submitter ⚠
- p.Leu105Pro Single submitter ⚠
- p.Lys112Thr Single submitter ⚠
- p.Lys147Arg Single submitter ⚠
- p.Lys147Asn Single submitter ⚠
- p.Lys174Arg Single submitter ⚠
- p.Lys174Met Single submitter ⚠
- p.Lys23Glu Single submitter ⚠
- p.Lys398Glu Single submitter ⚠
- p.Lys4Gln Single submitter ⚠
- p.Lys4Glu Single submitter ⚠
- p.Met246Arg Single submitter ⚠
- p.Met289Ile Single submitter ⚠
- p.Met380Thr Single submitter ⚠
- p.Pro3Ser Single submitter ⚠
- p.Pro449Leu Single submitter ⚠
- p.Ser446Pro Single submitter ⚠
- p.Thr139Met Single submitter ⚠
- p.Thr217Met Single submitter ⚠
- p.Thr392Met Single submitter ⚠
- p.Thr411Pro Single submitter ⚠
- p.Thr414Met Single submitter ⚠
- p.Trp396Arg Single submitter ⚠
- p.Val126Ala Single submitter ⚠
- p.Val191Leu Single submitter ⚠
- p.Val208Met Single submitter ⚠
- p.Val241Phe Single submitter ⚠
- p.Val323Met Single submitter ⚠
- p.Val359Ile Single submitter ⚠
- p.Val391Met Single submitter ⚠
- p.Val465Ile Single submitter ⚠
- p.Val64Ala Single submitter ⚠
- p.Val95Gly Single submitter ⚠