CFAP161 — 52 ClinVar variants
All ClinVar germline CFAP161 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
4 Likely benign · 48 Uncertain significance
Full CFAP161 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CFAP161 p.Ala295Ser Uncertain significance Single submitter
- CFAP161 p.Ala2Ser Uncertain significance Single submitter
- CFAP161 p.Arg226Gln Uncertain significance Single submitter
- CFAP161 p.Arg87His Uncertain significance Single submitter
- CFAP161 p.Asn14Lys Uncertain significance Single submitter
- CFAP161 p.Asn262Lys Uncertain significance Single submitter
- CFAP161 p.Asn4Lys Uncertain significance Single submitter
- CFAP161 p.Asp146Tyr Uncertain significance Single submitter
- CFAP161 p.Asp18Asn Uncertain significance Single submitter
- CFAP161 p.Asp253His Uncertain significance Single submitter
- CFAP161 p.Cys93Ser Uncertain significance Single submitter
- CFAP161 p.Gln48Lys Uncertain significance Single submitter
- CFAP161 p.Glu106Lys Uncertain significance Single submitter
- CFAP161 p.Ile122Thr Uncertain significance Single submitter
- CFAP161 p.Leu160Ser Uncertain significance Single submitter
- CFAP161 p.Leu21Arg Uncertain significance Single submitter
- CFAP161 p.Leu38Phe Uncertain significance Single submitter
- CFAP161 p.Lys69Glu Uncertain significance Single submitter
- CFAP161 p.Met159Val Uncertain significance Single submitter
- CFAP161 p.Met54Thr Uncertain significance Single submitter
- CFAP161 p.Phe235Ser Uncertain significance Single submitter
- CFAP161 p.Pro285Arg Uncertain significance Single submitter
- CFAP161 p.Pro75Leu Uncertain significance Single submitter
- CFAP161 p.Pro96Leu Uncertain significance Single submitter
- CFAP161 p.Ser176Phe Uncertain significance Single submitter
- CFAP161 p.Thr95Ala Uncertain significance Single submitter
- CFAP161 p.Tyr239Cys Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CFAP161 p.Ala115Thr Uncertain significance Single submitter
- CFAP161 p.Arg203Cys Uncertain significance Single submitter
- CFAP161 p.Arg203His Uncertain significance Single submitter
- CFAP161 p.Arg226Trp Uncertain significance Single submitter
- CFAP161 p.Asn220Tyr Uncertain significance Single submitter
- CFAP161 p.Asp273His Uncertain significance Single submitter
- CFAP161 p.Asp89Val Uncertain significance Single submitter
- CFAP161 p.Cys148Gly Uncertain significance Single submitter
- CFAP161 p.Gly208Ala Uncertain significance Single submitter
- CFAP161 p.His249Asn Uncertain significance Single submitter
- CFAP161 p.Ile64Met Uncertain significance Single submitter
- CFAP161 p.Lys216Asn Uncertain significance Single submitter
- CFAP161 p.Pro110Leu Uncertain significance Single submitter
- CFAP161 p.Pro200Ser Uncertain significance Single submitter
- CFAP161 p.Pro212Leu Uncertain significance Single submitter
- CFAP161 p.Pro8Leu Uncertain significance Single submitter
- CFAP161 p.Ser275Leu Uncertain significance Single submitter
- CFAP161 p.Thr126Ser Uncertain significance Single submitter
- CFAP161 p.Tyr66Asn Uncertain significance Single submitter
- CFAP161 p.Val10Ile Uncertain significance Single submitter
- CFAP161 p.Val187Asp Uncertain significance Single submitter
All CFAP161 variants
Likely benign 4
- p.Leu160= Single submitter
- p.Met292Leu Single submitter
- p.Val132Ala Single submitter
- p.Val58Ile Single submitter
Uncertain significance 48
- p.Ala115Thr Single submitter ⚠
- p.Ala295Ser Single submitter ⚠
- p.Ala2Ser Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg226Gln Single submitter ⚠
- p.Arg226Trp Single submitter ⚠
- p.Arg87His Single submitter ⚠
- p.Asn14Lys Single submitter ⚠
- p.Asn220Tyr Single submitter ⚠
- p.Asn262Lys Single submitter ⚠
- p.Asn4Lys Single submitter ⚠
- p.Asp146Tyr Single submitter ⚠
- p.Asp18Asn Single submitter ⚠
- p.Asp253His Single submitter ⚠
- p.Asp273His Single submitter ⚠
- p.Asp89Val Single submitter ⚠
- p.Cys148Gly Single submitter ⚠
- p.Cys93Ser Single submitter ⚠
- p.Gln48Lys Single submitter ⚠
- p.Glu106Lys Single submitter ⚠
- p.Gly208Ala Single submitter ⚠
- p.His249Asn Single submitter ⚠
- p.Ile122Thr Single submitter ⚠
- p.Ile64Met Single submitter ⚠
- p.Leu160Ser Single submitter ⚠
- p.Leu21Arg Single submitter ⚠
- p.Leu38Phe Single submitter ⚠
- p.Lys216Asn Single submitter ⚠
- p.Lys69Glu Single submitter ⚠
- p.Met159Val Single submitter ⚠
- p.Met54Thr Single submitter ⚠
- p.Phe235Ser Single submitter ⚠
- p.Pro110Leu Single submitter ⚠
- p.Pro200Ser Single submitter ⚠
- p.Pro212Leu Single submitter ⚠
- p.Pro285Arg Single submitter ⚠
- p.Pro75Leu Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Pro96Leu Single submitter ⚠
- p.Ser176Phe Single submitter ⚠
- p.Ser275Leu Single submitter ⚠
- p.Thr126Ser Single submitter ⚠
- p.Thr95Ala Single submitter ⚠
- p.Tyr239Cys Single submitter ⚠
- p.Tyr66Asn Single submitter ⚠
- p.Val10Ile Single submitter ⚠
- p.Val187Asp Single submitter ⚠