CFAP206 — 79 ClinVar variants
All ClinVar germline CFAP206 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
1 Pathogenic · 2 Likely benign · 76 Uncertain significance
Full CFAP206 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CFAP206 p.Ala255Thr Uncertain significance Single submitter
- CFAP206 p.Ala265Val Uncertain significance Single submitter
- CFAP206 p.Arg114Gln Uncertain significance Single submitter
- CFAP206 p.Arg182Cys Uncertain significance Single submitter
- CFAP206 p.Arg182His Uncertain significance Single submitter
- CFAP206 p.Arg381Gly Uncertain significance Single submitter
- CFAP206 p.Arg601Cys Uncertain significance Single submitter
- CFAP206 p.Asn435His Uncertain significance Single submitter
- CFAP206 p.Asn477Ser Uncertain significance Single submitter
- CFAP206 p.Asn520Ser Uncertain significance Single submitter
- CFAP206 p.Asp209Glu Uncertain significance Single submitter
- CFAP206 p.Asp378Tyr Uncertain significance Single submitter
- CFAP206 p.Asp503Glu Uncertain significance Single submitter
- CFAP206 p.Cys21Tyr Uncertain significance Single submitter
- CFAP206 p.Gln258His Uncertain significance Single submitter
- CFAP206 p.Gln351His Uncertain significance Single submitter
- CFAP206 p.Gln498Lys Uncertain significance Single submitter
- CFAP206 p.Glu128Lys Uncertain significance Single submitter
- CFAP206 p.Glu445Gly Uncertain significance Single submitter
- CFAP206 p.Glu621Lys Uncertain significance Single submitter
- CFAP206 p.Gly286Ser Uncertain significance Single submitter
- CFAP206 p.Gly298Glu Uncertain significance Single submitter
- CFAP206 p.His225Arg Uncertain significance Single submitter
- CFAP206 p.His465Tyr Uncertain significance Single submitter
- CFAP206 p.His505Arg Uncertain significance Single submitter
- CFAP206 p.Ile10Val Uncertain significance Single submitter
- CFAP206 p.Ile322Val Uncertain significance Single submitter
- CFAP206 p.Ile440Val Uncertain significance Single submitter
- CFAP206 p.Ile507Leu Uncertain significance Single submitter
- CFAP206 p.Ile507Thr Uncertain significance Single submitter
- CFAP206 p.Leu561Phe Uncertain significance Single submitter
- CFAP206 p.Lys411Arg Uncertain significance Single submitter
- CFAP206 p.Lys473Arg Uncertain significance Single submitter
- CFAP206 p.Met366Arg Uncertain significance Single submitter
- CFAP206 p.Met36Val Uncertain significance Single submitter
- CFAP206 p.Met89Thr Uncertain significance Single submitter
- CFAP206 p.Ser8Asn Uncertain significance Single submitter
- CFAP206 p.Thr157Ala Uncertain significance Single submitter
- CFAP206 p.Thr171Ile Uncertain significance Single submitter
- CFAP206 p.Thr241Arg Uncertain significance Single submitter
- CFAP206 p.Thr449Ile Uncertain significance Single submitter
- CFAP206 p.Thr527Lys Uncertain significance Single submitter
- CFAP206 p.Thr527Met Uncertain significance Single submitter
- CFAP206 p.Tyr267Cys Uncertain significance Single submitter
- CFAP206 p.Val28Phe Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- CFAP206 p.Ala121Ser Uncertain significance Single submitter
- CFAP206 p.Ala213Val Uncertain significance Single submitter
- CFAP206 p.Ala265Glu Uncertain significance Single submitter
- CFAP206 p.Ala393Val Uncertain significance Single submitter
- CFAP206 p.Arg132Trp Uncertain significance Single submitter
- CFAP206 p.Arg234Trp Uncertain significance Single submitter
- CFAP206 p.Arg417Trp Uncertain significance Single submitter
- CFAP206 p.Arg550Leu Uncertain significance Single submitter
- CFAP206 p.Arg69Gln Uncertain significance Single submitter
- CFAP206 p.Arg69Trp Uncertain significance Single submitter
- CFAP206 p.Arg94Gln Uncertain significance Single submitter
- CFAP206 p.Asp282Gly Uncertain significance Single submitter
- CFAP206 p.Asp388Gly Uncertain significance Single submitter
- CFAP206 p.Asp428Tyr Uncertain significance Single submitter
- CFAP206 p.Asp454Tyr Uncertain significance Single submitter
- CFAP206 p.Asp88Asn Uncertain significance Single submitter
- CFAP206 p.Asp88Gly Uncertain significance Single submitter
- CFAP206 p.Glu358Lys Uncertain significance Single submitter
- CFAP206 p.Gly372Ala Uncertain significance Single submitter
- CFAP206 p.Leu326Phe Uncertain significance Single submitter
- CFAP206 p.Lys612Asn Uncertain significance Single submitter
- CFAP206 p.Met253Arg Uncertain significance Single submitter
- CFAP206 p.Pro220Leu Uncertain significance Single submitter
- CFAP206 p.Pro403Gln Uncertain significance Single submitter
- CFAP206 p.Ser136Thr Uncertain significance Single submitter
- CFAP206 p.Ser57Cys Uncertain significance Single submitter
- CFAP206 p.Thr406Arg Uncertain significance Single submitter
- CFAP206 p.Thr423Met Uncertain significance Single submitter
- CFAP206 p.Thr554Ala Uncertain significance Single submitter
- CFAP206 p.Val237Leu Uncertain significance Single submitter
- CFAP206 p.Val314Leu Uncertain significance Single submitter
All CFAP206 variants
Pathogenic 1
- p.Asn477fs No assertion criteria Abnormal sperm tail morphology
Likely benign 2
- p.Arg234Gln Single submitter
- p.Met67Val Single submitter
Uncertain significance 76
- p.Ala121Ser Single submitter ⚠
- p.Ala213Val Single submitter ⚠
- p.Ala255Thr Single submitter ⚠
- p.Ala265Glu Single submitter ⚠
- p.Ala265Val Single submitter ⚠
- p.Ala393Val Single submitter ⚠
- p.Arg114Gln Single submitter ⚠
- p.Arg132Trp Single submitter ⚠
- p.Arg182Cys Single submitter ⚠
- p.Arg182His Single submitter ⚠
- p.Arg234Trp Single submitter ⚠
- p.Arg381Gly Single submitter ⚠
- p.Arg417Trp Single submitter ⚠
- p.Arg550Leu Single submitter ⚠
- p.Arg601Cys Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Arg69Trp Single submitter ⚠
- p.Arg94Gln Single submitter ⚠
- p.Asn435His Single submitter ⚠
- p.Asn477Ser Single submitter ⚠
- p.Asn520Ser Single submitter ⚠
- p.Asp209Glu Single submitter ⚠
- p.Asp282Gly Single submitter ⚠
- p.Asp378Tyr Single submitter ⚠
- p.Asp388Gly Single submitter ⚠
- p.Asp428Tyr Single submitter ⚠
- p.Asp454Tyr Single submitter ⚠
- p.Asp503Glu Single submitter ⚠
- p.Asp88Asn Single submitter ⚠
- p.Asp88Gly Single submitter ⚠
- p.Cys21Tyr Single submitter ⚠
- p.Gln258His Single submitter ⚠
- p.Gln351His Single submitter ⚠
- p.Gln498Lys Single submitter ⚠
- p.Glu128Lys Single submitter ⚠
- p.Glu358Lys Single submitter ⚠
- p.Glu445Gly Single submitter ⚠
- p.Glu621Lys Single submitter ⚠
- p.Gly286Ser Single submitter ⚠
- p.Gly298Glu Single submitter ⚠
- p.Gly372Ala Single submitter ⚠
- p.His225Arg Single submitter ⚠
- p.His465Tyr Single submitter ⚠
- p.His505Arg Single submitter ⚠
- p.Ile10Val Single submitter ⚠
- p.Ile322Val Single submitter ⚠
- p.Ile440Val Single submitter ⚠
- p.Ile507Leu Single submitter ⚠
- p.Ile507Thr Single submitter ⚠
- p.Leu326Phe Single submitter ⚠
- p.Leu561Phe Single submitter ⚠
- p.Lys411Arg Single submitter ⚠
- p.Lys473Arg Single submitter ⚠
- p.Lys612Asn Single submitter ⚠
- p.Met253Arg Single submitter ⚠
- p.Met366Arg Single submitter ⚠
- p.Met36Val Single submitter ⚠
- p.Met89Thr Single submitter ⚠
- p.Pro220Leu Single submitter ⚠
- p.Pro403Gln Single submitter ⚠
- p.Ser136Thr Single submitter ⚠
- p.Ser57Cys Single submitter ⚠
- p.Ser8Asn Single submitter ⚠
- p.Thr157Ala Single submitter ⚠
- p.Thr171Ile Single submitter ⚠
- p.Thr241Arg Single submitter ⚠
- p.Thr406Arg Single submitter ⚠
- p.Thr423Met Single submitter ⚠
- p.Thr449Ile Single submitter ⚠
- p.Thr527Lys Single submitter ⚠
- p.Thr527Met Single submitter ⚠
- p.Thr554Ala Single submitter ⚠
- p.Tyr267Cys Single submitter ⚠
- p.Val237Leu Single submitter ⚠
- p.Val28Phe Single submitter ⚠
- p.Val314Leu Single submitter ⚠