CFAP263 — 74 ClinVar variants
All ClinVar germline CFAP263 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →
2 Likely benign · 72 Uncertain significance
Full CFAP263 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 72
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CFAP263 p.Ala371Thr Uncertain significance Single submitter
- CFAP263 p.Ala39Thr Uncertain significance Single submitter
- CFAP263 p.Arg116Gln Uncertain significance Single submitter
- CFAP263 p.Arg181Gln Uncertain significance Single submitter
- CFAP263 p.Arg86Gln Uncertain significance Single submitter
- CFAP263 p.Arg91His Uncertain significance Single submitter
- CFAP263 p.Asn258Ser Uncertain significance Single submitter
- CFAP263 p.Asp219Val Uncertain significance Single submitter
- CFAP263 p.Gln127Arg Uncertain significance Single submitter
- CFAP263 p.Glu277Asp Uncertain significance Single submitter
- CFAP263 p.Glu55Lys Uncertain significance Single submitter
- CFAP263 p.His117Tyr Uncertain significance Single submitter
- CFAP263 p.His128Gln Uncertain significance Single submitter
- CFAP263 p.His148Leu Uncertain significance Single submitter
- CFAP263 p.Ile175Val Uncertain significance Single submitter
- CFAP263 p.Ile270Val Uncertain significance Single submitter
- CFAP263 p.Ile69Val Uncertain significance Single submitter
- CFAP263 p.Lys156Arg Uncertain significance Single submitter
- CFAP263 p.Lys266Gln Uncertain significance Single submitter
- CFAP263 p.Lys301Arg Uncertain significance Single submitter
- CFAP263 p.Lys353Arg Uncertain significance Single submitter
- CFAP263 p.Met172Thr Uncertain significance Single submitter
- CFAP263 p.Met46Val Uncertain significance Single submitter
- CFAP263 p.Ser141Gly Uncertain significance Single submitter
- CFAP263 p.Ser144Leu Uncertain significance Single submitter
- CFAP263 p.Ser337Arg Uncertain significance Single submitter
- CFAP263 p.Ser337Asn Uncertain significance Single submitter
- CFAP263 p.Ser70Ala Uncertain significance Single submitter
- CFAP263 p.Thr87Arg Uncertain significance Single submitter
- CFAP263 p.Tyr271His Uncertain significance Single submitter
- CFAP263 p.Val305Met Uncertain significance Single submitter
- CFAP263 p.Val321Leu Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- CFAP263 p.Ala122Val Uncertain significance Single submitter
- CFAP263 p.Ala131Val Uncertain significance Single submitter
- CFAP263 p.Ala167Ser Uncertain significance Single submitter
- CFAP263 p.Arg124Cys Uncertain significance Single submitter
- CFAP263 p.Arg124His Uncertain significance Single submitter
- CFAP263 p.Arg180His Uncertain significance Single submitter
- CFAP263 p.Arg190His Uncertain significance Single submitter
- CFAP263 p.Arg190Ser Uncertain significance Single submitter
- CFAP263 p.Arg299Gln Uncertain significance Single submitter
- CFAP263 p.Arg310Gln Uncertain significance Single submitter
- CFAP263 p.Arg317Gln Uncertain significance Single submitter
- CFAP263 p.Arg317Pro Uncertain significance Single submitter
- CFAP263 p.Arg361Gly Uncertain significance Single submitter
- CFAP263 p.Arg361Leu Uncertain significance Single submitter
- CFAP263 p.Arg81Leu Uncertain significance Single submitter
- CFAP263 p.Arg82Thr Uncertain significance Single submitter
- CFAP263 p.Arg91Cys Uncertain significance Single submitter
- CFAP263 p.Asn240Ser Uncertain significance Single submitter
- CFAP263 p.Asp219Asn Uncertain significance Single submitter
- CFAP263 p.Gln206Arg Uncertain significance Single submitter
- CFAP263 p.Glu315Lys Uncertain significance Single submitter
- CFAP263 p.Glu367Gly Uncertain significance Single submitter
- CFAP263 p.Glu7Lys Uncertain significance Single submitter
- CFAP263 p.His148Pro Uncertain significance Single submitter
- CFAP263 p.His355Arg Uncertain significance Single submitter
- CFAP263 p.Leu196Val Uncertain significance Single submitter
- CFAP263 p.Lys156Asn Uncertain significance Single submitter
- CFAP263 p.Met172Lys Uncertain significance Single submitter
- CFAP263 p.Met350Ile Uncertain significance Single submitter
- CFAP263 p.Met362Arg Uncertain significance Single submitter
- CFAP263 p.Phe222Val Uncertain significance Single submitter
- CFAP263 p.Ser159Phe Uncertain significance Single submitter
- CFAP263 p.Ser250Cys Uncertain significance Single submitter
- CFAP263 p.Ser6Phe Uncertain significance Single submitter
- CFAP263 p.Ser85Tyr Uncertain significance Single submitter
- CFAP263 p.Thr235Ile Uncertain significance Single submitter
- CFAP263 p.Thr253Ile Uncertain significance Single submitter
- CFAP263 p.Thr323Ile Uncertain significance Single submitter
- CFAP263 p.Tyr324His Uncertain significance Single submitter
- CFAP263 p.Val325Ile Uncertain significance Single submitter
All CFAP263 variants
Likely benign 2
- p.Arg82Lys Single submitter
- p.Tyr51= Single submitter
Uncertain significance 72
- p.Ala122Val Single submitter ⚠
- p.Ala131Val Single submitter ⚠
- p.Ala167Ser Single submitter ⚠
- p.Ala371Thr Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Arg116Gln Single submitter ⚠
- p.Arg124Cys Single submitter ⚠
- p.Arg124His Single submitter ⚠
- p.Arg180His Single submitter ⚠
- p.Arg181Gln Single submitter ⚠
- p.Arg190His Single submitter ⚠
- p.Arg190Ser Single submitter ⚠
- p.Arg299Gln Single submitter ⚠
- p.Arg310Gln Single submitter ⚠
- p.Arg317Gln Single submitter ⚠
- p.Arg317Pro Single submitter ⚠
- p.Arg361Gly Single submitter ⚠
- p.Arg361Leu Single submitter ⚠
- p.Arg81Leu Single submitter ⚠
- p.Arg82Thr Single submitter ⚠
- p.Arg86Gln Single submitter ⚠
- p.Arg91Cys Single submitter ⚠
- p.Arg91His Single submitter ⚠
- p.Asn240Ser Single submitter ⚠
- p.Asn258Ser Single submitter ⚠
- p.Asp219Asn Single submitter ⚠
- p.Asp219Val Single submitter ⚠
- p.Gln127Arg Single submitter ⚠
- p.Gln206Arg Single submitter ⚠
- p.Glu277Asp Single submitter ⚠
- p.Glu315Lys Single submitter ⚠
- p.Glu367Gly Single submitter ⚠
- p.Glu55Lys Single submitter ⚠
- p.Glu7Lys Single submitter ⚠
- p.His117Tyr Single submitter ⚠
- p.His128Gln Single submitter ⚠
- p.His148Leu Single submitter ⚠
- p.His148Pro Single submitter ⚠
- p.His355Arg Single submitter ⚠
- p.Ile175Val Single submitter ⚠
- p.Ile270Val Single submitter ⚠
- p.Ile69Val Single submitter ⚠
- p.Leu196Val Single submitter ⚠
- p.Lys156Arg Single submitter ⚠
- p.Lys156Asn Single submitter ⚠
- p.Lys266Gln Single submitter ⚠
- p.Lys301Arg Single submitter ⚠
- p.Lys353Arg Single submitter ⚠
- p.Met172Lys Single submitter ⚠
- p.Met172Thr Single submitter ⚠
- p.Met350Ile Single submitter ⚠
- p.Met362Arg Single submitter ⚠
- p.Met46Val Single submitter ⚠
- p.Phe222Val Single submitter ⚠
- p.Ser141Gly Single submitter ⚠
- p.Ser144Leu Single submitter ⚠
- p.Ser159Phe Single submitter ⚠
- p.Ser250Cys Single submitter ⚠
- p.Ser337Arg Single submitter ⚠
- p.Ser337Asn Single submitter ⚠
- p.Ser6Phe Single submitter ⚠
- p.Ser70Ala Single submitter ⚠
- p.Ser85Tyr Single submitter ⚠
- p.Thr235Ile Single submitter ⚠
- p.Thr253Ile Single submitter ⚠
- p.Thr323Ile Single submitter ⚠
- p.Thr87Arg Single submitter ⚠
- p.Tyr271His Single submitter ⚠
- p.Tyr324His Single submitter ⚠
- p.Val305Met Single submitter ⚠
- p.Val321Leu Single submitter ⚠
- p.Val325Ile Single submitter ⚠