CFAP36 — 44 ClinVar variants
All ClinVar germline CFAP36 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
1 Likely benign · 43 Uncertain significance
Full CFAP36 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CFAP36 p.Arg126Gln Uncertain significance Single submitter
- CFAP36 p.Arg280Thr Uncertain significance Single submitter
- CFAP36 p.Asn132Ser Uncertain significance Single submitter
- CFAP36 p.Asp144Asn Uncertain significance Single submitter
- CFAP36 p.Asp281Tyr Uncertain significance Single submitter
- CFAP36 p.Cys83Arg Uncertain significance Single submitter
- CFAP36 p.Gln129Glu Uncertain significance Single submitter
- CFAP36 p.Gln296Glu Uncertain significance Single submitter
- CFAP36 p.Glu14Lys Uncertain significance Single submitter
- CFAP36 p.Glu307Lys Uncertain significance Single submitter
- CFAP36 p.Glu8Asp Uncertain significance Single submitter
- CFAP36 p.His151Tyr Uncertain significance Single submitter
- CFAP36 p.His191Gln Uncertain significance Single submitter
- CFAP36 p.His218Arg Uncertain significance Single submitter
- CFAP36 p.Ile127Leu Uncertain significance Single submitter
- CFAP36 p.Ile254Thr Uncertain significance Single submitter
- CFAP36 p.Lys288Arg Uncertain significance Single submitter
- CFAP36 p.Lys288Gln Uncertain significance Single submitter
- CFAP36 p.Lys322Arg Uncertain significance Single submitter
- CFAP36 p.Met286Lys Uncertain significance Single submitter
- CFAP36 p.Met298Ile Uncertain significance Single submitter
- CFAP36 p.Pro315Ser Uncertain significance Single submitter
- CFAP36 p.Thr140Ile Uncertain significance Single submitter
- CFAP36 p.Thr312Ile Uncertain significance Single submitter
- CFAP36 p.Thr324Ile Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CFAP36 p.Ala332Thr Uncertain significance Single submitter
- CFAP36 p.Arg176Thr Uncertain significance Single submitter
- CFAP36 p.Arg21Pro Uncertain significance Single submitter
- CFAP36 p.Arg328Lys Uncertain significance Single submitter
- CFAP36 p.Glu104Ala Uncertain significance Single submitter
- CFAP36 p.Glu152Asp Uncertain significance Single submitter
- CFAP36 p.Glu232Gly Uncertain significance Single submitter
- CFAP36 p.Glu268Asp Uncertain significance Single submitter
- CFAP36 p.Glu44Gly Uncertain significance Single submitter
- CFAP36 p.Ile118Thr Uncertain significance Single submitter
- CFAP36 p.Ile29Met Uncertain significance Single submitter
- CFAP36 p.Leu122Met Uncertain significance Single submitter
- CFAP36 p.Ser15Gly Uncertain significance Single submitter
- CFAP36 p.Ser262Pro Uncertain significance Single submitter
- CFAP36 p.Ser93Leu Uncertain significance Single submitter
- CFAP36 p.Thr292Ile Uncertain significance Single submitter
- CFAP36 p.Val100Leu Uncertain significance Single submitter
- CFAP36 p.Val12Leu Uncertain significance Single submitter
All CFAP36 variants
Likely benign 1
- p.His151= Single submitter
Uncertain significance 43
- p.Ala332Thr Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg176Thr Single submitter ⚠
- p.Arg21Pro Single submitter ⚠
- p.Arg280Thr Single submitter ⚠
- p.Arg328Lys Single submitter ⚠
- p.Asn132Ser Single submitter ⚠
- p.Asp144Asn Single submitter ⚠
- p.Asp281Tyr Single submitter ⚠
- p.Cys83Arg Single submitter ⚠
- p.Gln129Glu Single submitter ⚠
- p.Gln296Glu Single submitter ⚠
- p.Glu104Ala Single submitter ⚠
- p.Glu14Lys Single submitter ⚠
- p.Glu152Asp Single submitter ⚠
- p.Glu232Gly Single submitter ⚠
- p.Glu268Asp Single submitter ⚠
- p.Glu307Lys Single submitter ⚠
- p.Glu44Gly Single submitter ⚠
- p.Glu8Asp Single submitter ⚠
- p.His151Tyr Single submitter ⚠
- p.His191Gln Single submitter ⚠
- p.His218Arg Single submitter ⚠
- p.Ile118Thr Single submitter ⚠
- p.Ile127Leu Single submitter ⚠
- p.Ile254Thr Single submitter ⚠
- p.Ile29Met Single submitter ⚠
- p.Leu122Met Single submitter ⚠
- p.Lys288Arg Single submitter ⚠
- p.Lys288Gln Single submitter ⚠
- p.Lys322Arg Single submitter ⚠
- p.Met286Lys Single submitter ⚠
- p.Met298Ile Single submitter ⚠
- p.Pro315Ser Single submitter ⚠
- p.Ser15Gly Single submitter ⚠
- p.Ser262Pro Single submitter ⚠
- p.Ser93Leu Single submitter ⚠
- p.Thr140Ile Single submitter ⚠
- p.Thr292Ile Single submitter ⚠
- p.Thr312Ile Single submitter ⚠
- p.Thr324Ile Single submitter ⚠
- p.Val100Leu Single submitter ⚠
- p.Val12Leu Single submitter ⚠