CFAP77 — 68 ClinVar variants
All ClinVar germline CFAP77 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
4 Likely benign · 64 Uncertain significance
Full CFAP77 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CFAP77 c.196-16283C>G Uncertain significance Single submitter
- CFAP77 c.196-16327A>G Uncertain significance Single submitter
- CFAP77 c.196-16333C>T Uncertain significance Single submitter
- CFAP77 p.Arg13Gln Uncertain significance Single submitter
- CFAP77 p.Arg173Gln Uncertain significance Single submitter
- CFAP77 p.Arg22Ser Uncertain significance Single submitter
- CFAP77 p.Arg23Leu Uncertain significance Single submitter
- CFAP77 p.Arg247Cys Uncertain significance Single submitter
- CFAP77 p.Arg266Gln Uncertain significance Single submitter
- CFAP77 p.Arg266Trp Uncertain significance Single submitter
- CFAP77 p.Arg272Cys Uncertain significance Single submitter
- CFAP77 p.Arg90Gln Uncertain significance Single submitter
- CFAP77 p.Asp153His Uncertain significance Single submitter
- CFAP77 p.Glu115Gln Uncertain significance Single submitter
- CFAP77 p.Glu115Lys Uncertain significance Single submitter
- CFAP77 p.Glu160Lys Uncertain significance Single submitter
- CFAP77 p.Glu48Lys Uncertain significance Single submitter
- CFAP77 p.Gly131Arg Uncertain significance Single submitter
- CFAP77 p.Gly51Arg Uncertain significance Single submitter
- CFAP77 p.His238Tyr Uncertain significance Single submitter
- CFAP77 p.His241Gln Uncertain significance Single submitter
- CFAP77 p.Ile41Leu Uncertain significance Single submitter
- CFAP77 p.Leu92Pro Uncertain significance Single submitter
- CFAP77 p.Met157Val Uncertain significance Single submitter
- CFAP77 p.Met45Leu Uncertain significance Single submitter
- CFAP77 p.Pro162His Uncertain significance Single submitter
- CFAP77 p.Pro179Thr Uncertain significance Single submitter
- CFAP77 p.Pro230Leu Uncertain significance Single submitter
- CFAP77 p.Pro32Leu Uncertain significance Single submitter
- CFAP77 p.Ser6Ile Uncertain significance Single submitter
- CFAP77 p.Ser6Thr Uncertain significance Single submitter
- CFAP77 p.Tyr217Phe Uncertain significance Single submitter
- CFAP77 p.Val193Leu Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- CFAP77 c.196-16315C>T Uncertain significance Single submitter
- CFAP77 c.196-16357C>T Uncertain significance Single submitter
- CFAP77 p.Ala127Val Uncertain significance Single submitter
- CFAP77 p.Ala256Val Uncertain significance Single submitter
- CFAP77 p.Arg118Gln Uncertain significance Single submitter
- CFAP77 p.Arg125Cys Uncertain significance Single submitter
- CFAP77 p.Arg125His Uncertain significance Single submitter
- CFAP77 p.Arg136Gln Likely benign Single submitter
- CFAP77 p.Arg136Gly Uncertain significance Single submitter
- CFAP77 p.Arg142His Uncertain significance Single submitter
- CFAP77 p.Arg156Cys Uncertain significance Single submitter
- CFAP77 p.Arg156His Uncertain significance Single submitter
- CFAP77 p.Arg187Trp Uncertain significance Single submitter
- CFAP77 p.Arg258His Uncertain significance Single submitter
- CFAP77 p.Arg49Pro Uncertain significance Single submitter
- CFAP77 p.Arg72Gln Uncertain significance Single submitter
- CFAP77 p.Arg74Gly Uncertain significance Single submitter
- CFAP77 p.Asp10Tyr Uncertain significance Single submitter
- CFAP77 p.Asp146Asn Uncertain significance Single submitter
- CFAP77 p.Glu195Val Uncertain significance Single submitter
- CFAP77 p.Glu48Gln Uncertain significance Single submitter
- CFAP77 p.Gly126Arg Uncertain significance Single submitter
- CFAP77 p.Gly131Ser Uncertain significance Single submitter
- CFAP77 p.Gly94Arg Uncertain significance Single submitter
- CFAP77 p.Leu62Ile Uncertain significance Single submitter
- CFAP77 p.Pro229Leu Uncertain significance Single submitter
- CFAP77 p.Pro61Ala Uncertain significance Single submitter
- CFAP77 p.Pro71Leu Uncertain significance Single submitter
- CFAP77 p.Ser177Phe Uncertain significance Single submitter
- CFAP77 p.Thr178Ile Uncertain significance Single submitter
- CFAP77 p.Val53Met Uncertain significance Single submitter
- CFAP77 p.Val96Ile Uncertain significance Single submitter
All CFAP77 variants
Likely benign 4
- p.Arg102His Single submitter
- p.Arg136Gln Single submitter ⚠
- p.Leu11Pro Single submitter
- p.Met157Leu Single submitter
Uncertain significance 64
- c.196-16283C>G Single submitter ⚠
- c.196-16315C>T Single submitter ⚠
- c.196-16327A>G Single submitter ⚠
- c.196-16333C>T Single submitter ⚠
- c.196-16357C>T Single submitter ⚠
- p.Ala127Val Single submitter ⚠
- p.Ala256Val Single submitter ⚠
- p.Arg118Gln Single submitter ⚠
- p.Arg125Cys Single submitter ⚠
- p.Arg125His Single submitter ⚠
- p.Arg136Gly Single submitter ⚠
- p.Arg13Gln Single submitter ⚠
- p.Arg142His Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg156His Single submitter ⚠
- p.Arg173Gln Single submitter ⚠
- p.Arg187Trp Single submitter ⚠
- p.Arg22Ser Single submitter ⚠
- p.Arg23Leu Single submitter ⚠
- p.Arg247Cys Single submitter ⚠
- p.Arg258His Single submitter ⚠
- p.Arg266Gln Single submitter ⚠
- p.Arg266Trp Single submitter ⚠
- p.Arg272Cys Single submitter ⚠
- p.Arg49Pro Single submitter ⚠
- p.Arg72Gln Single submitter ⚠
- p.Arg74Gly Single submitter ⚠
- p.Arg90Gln Single submitter ⚠
- p.Asp10Tyr Single submitter ⚠
- p.Asp146Asn Single submitter ⚠
- p.Asp153His Single submitter ⚠
- p.Glu115Gln Single submitter ⚠
- p.Glu115Lys Single submitter ⚠
- p.Glu160Lys Single submitter ⚠
- p.Glu195Val Single submitter ⚠
- p.Glu48Gln Single submitter ⚠
- p.Glu48Lys Single submitter ⚠
- p.Gly126Arg Single submitter ⚠
- p.Gly131Arg Single submitter ⚠
- p.Gly131Ser Single submitter ⚠
- p.Gly51Arg Single submitter ⚠
- p.Gly94Arg Single submitter ⚠
- p.His238Tyr Single submitter ⚠
- p.His241Gln Single submitter ⚠
- p.Ile41Leu Single submitter ⚠
- p.Leu62Ile Single submitter ⚠
- p.Leu92Pro Single submitter ⚠
- p.Met157Val Single submitter ⚠
- p.Met45Leu Single submitter ⚠
- p.Pro162His Single submitter ⚠
- p.Pro179Thr Single submitter ⚠
- p.Pro229Leu Single submitter ⚠
- p.Pro230Leu Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Pro61Ala Single submitter ⚠
- p.Pro71Leu Single submitter ⚠
- p.Ser177Phe Single submitter ⚠
- p.Ser6Ile Single submitter ⚠
- p.Ser6Thr Single submitter ⚠
- p.Thr178Ile Single submitter ⚠
- p.Tyr217Phe Single submitter ⚠
- p.Val193Leu Single submitter ⚠
- p.Val53Met Single submitter ⚠
- p.Val96Ile Single submitter ⚠