CFAP97 — 107 ClinVar variants
All ClinVar germline CFAP97 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 94 flagged for review →
4 Benign · 9 Likely benign · 94 Uncertain significance
Full CFAP97 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 94
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CFAP97 p.Ala152Gly Uncertain significance Single submitter
- CFAP97 p.Ala448Thr Uncertain significance Single submitter
- CFAP97 p.Arg508Pro Uncertain significance Single submitter
- CFAP97 p.Arg519Gln Uncertain significance Single submitter
- CFAP97 p.Arg99Gly Uncertain significance Single submitter
- CFAP97 p.Asn37Ser Uncertain significance Single submitter
- CFAP97 p.Asp297Val Uncertain significance Single submitter
- CFAP97 p.Asp332His Uncertain significance Single submitter
- CFAP97 p.Asp332Tyr Uncertain significance Single submitter
- CFAP97 p.Asp367Asn Uncertain significance Single submitter
- CFAP97 p.Asp512Gly Uncertain significance Single submitter
- CFAP97 p.Cys167Tyr Uncertain significance Single submitter
- CFAP97 p.Cys27Ser Uncertain significance Single submitter
- CFAP97 p.Gln337Arg Uncertain significance Single submitter
- CFAP97 p.Glu11Gln Uncertain significance Single submitter
- CFAP97 p.Glu231Val Uncertain significance Single submitter
- CFAP97 p.Glu316Lys Uncertain significance Single submitter
- CFAP97 p.Gly109Glu Uncertain significance Single submitter
- CFAP97 p.Gly10Asp Uncertain significance Single submitter
- CFAP97 p.His146Tyr Uncertain significance Single submitter
- CFAP97 p.His14Arg Uncertain significance Single submitter
- CFAP97 p.His243Tyr Uncertain significance Single submitter
- CFAP97 p.His333Arg Uncertain significance Single submitter
- CFAP97 p.His333Leu Uncertain significance Single submitter
- CFAP97 p.His341Arg Uncertain significance Single submitter
- CFAP97 p.His365Arg Uncertain significance Single submitter
- CFAP97 p.His465Arg Uncertain significance Single submitter
- CFAP97 p.His517Tyr Uncertain significance Single submitter
- CFAP97 p.Ile44Thr Uncertain significance Single submitter
- CFAP97 p.Ile7Thr Uncertain significance Single submitter
- CFAP97 p.Leu271Met Uncertain significance Single submitter
- CFAP97 p.Leu395Ser Uncertain significance Single submitter
- CFAP97 p.Leu398Pro Uncertain significance Single submitter
- CFAP97 p.Leu64Val Uncertain significance Single submitter
- CFAP97 p.Lys144Ile Uncertain significance Single submitter
- CFAP97 p.Lys310Thr Uncertain significance Single submitter
- CFAP97 p.Lys35Glu Uncertain significance Single submitter
- CFAP97 p.Phe379Val Uncertain significance Single submitter
- CFAP97 p.Pro117Arg Uncertain significance Single submitter
- CFAP97 p.Pro451Ala Uncertain significance Single submitter
- CFAP97 p.Pro475Ser Uncertain significance Single submitter
- CFAP97 p.Pro513Ser Uncertain significance Single submitter
- CFAP97 p.Pro522Leu Uncertain significance Single submitter
- CFAP97 p.Pro522Ser Uncertain significance Single submitter
- CFAP97 p.Pro76Ser Uncertain significance Single submitter
- CFAP97 p.Ser212Pro Uncertain significance Single submitter
- CFAP97 p.Ser378Phe Uncertain significance Single submitter
- CFAP97 p.Thr156Pro Uncertain significance Single submitter
- CFAP97 p.Thr238Ile Uncertain significance Single submitter
- CFAP97 p.Thr251Ser Uncertain significance Single submitter
- CFAP97 p.Thr410Ile Uncertain significance Single submitter
- CFAP97 p.Thr529Ser Uncertain significance Single submitter
- CFAP97 p.Thr59Ala Uncertain significance Single submitter
- CFAP97 p.Tyr292Asn Uncertain significance Single submitter
- CFAP97 p.Tyr292His Uncertain significance Single submitter
- CFAP97 p.Val295Ala Uncertain significance Single submitter
- CFAP97 p.Val319Ala Uncertain significance Single submitter
- CFAP97 p.Val326Leu Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- CFAP97 p.Arg381Ser Uncertain significance Single submitter
- CFAP97 p.Arg389Gln Uncertain significance Single submitter
- CFAP97 p.Arg457His Uncertain significance Single submitter
- CFAP97 p.Arg479Trp Uncertain significance Single submitter
- CFAP97 p.Arg508Gln Uncertain significance Single submitter
- CFAP97 p.Arg528Cys Uncertain significance Single submitter
- CFAP97 p.Asn376Lys Uncertain significance Single submitter
- CFAP97 p.Asn467Asp Uncertain significance Single submitter
- CFAP97 p.Asp254Asn Uncertain significance Single submitter
- CFAP97 p.Asp463Gly Uncertain significance Single submitter
- CFAP97 p.Glu23Ala Uncertain significance Single submitter
- CFAP97 p.Glu431Gln Uncertain significance Single submitter
- CFAP97 p.Glu9Lys Uncertain significance Single submitter
- CFAP97 p.His335Pro Uncertain significance Single submitter
- CFAP97 p.Lys111Ile Uncertain significance Single submitter
- CFAP97 p.Lys150Gln Uncertain significance Single submitter
- CFAP97 p.Lys164Glu Uncertain significance Single submitter
- CFAP97 p.Lys408Asn Uncertain significance Single submitter
- CFAP97 p.Met462Ile Uncertain significance Single submitter
- CFAP97 p.Phe353Leu Uncertain significance Single submitter
- CFAP97 p.Pro265Ser Uncertain significance Single submitter
- CFAP97 p.Ser200Leu Uncertain significance Single submitter
- CFAP97 p.Ser236Gly Uncertain significance Single submitter
- CFAP97 p.Ser320Pro Uncertain significance Single submitter
- CFAP97 p.Ser329Cys Uncertain significance Single submitter
- CFAP97 p.Ser414Leu Uncertain significance Single submitter
- CFAP97 p.Ser458Ala Uncertain significance Single submitter
- CFAP97 p.Ser509Leu Uncertain significance Single submitter
- CFAP97 p.Ser97Phe Uncertain significance Single submitter
- CFAP97 p.Thr380Ile Uncertain significance Single submitter
- CFAP97 p.Tyr470Cys Uncertain significance Single submitter
- CFAP97 p.Tyr470Phe Uncertain significance Single submitter
- CFAP97 p.Val114Met Uncertain significance Single submitter
- CFAP97 p.Val287Met Uncertain significance Single submitter
- CFAP97 p.Val449Met Uncertain significance Single submitter
- CFAP97 p.Val73Met Uncertain significance Single submitter
All CFAP97 variants
Benign 4
- p.Glu383= Multiple submitters
- p.Thr499Met Multiple submitters
- p.His113= Single submitter
- p.Ile387= Single submitter
Likely benign 9
- p.Ala510= Single submitter
- p.Ala510Val Single submitter
- p.Gly374Arg Single submitter
- p.His335Tyr Single submitter
- p.Leu421= Single submitter
- p.Met57Ile Single submitter
- p.Ser161Gly Single submitter
- p.Ser90Asn Single submitter
- p.Val73Leu Single submitter
Uncertain significance 94
- p.Ala152Gly Single submitter ⚠
- p.Ala448Thr Single submitter ⚠
- p.Arg381Ser Single submitter ⚠
- p.Arg389Gln Single submitter ⚠
- p.Arg457His Single submitter ⚠
- p.Arg479Trp Single submitter ⚠
- p.Arg508Gln Single submitter ⚠
- p.Arg508Pro Single submitter ⚠
- p.Arg519Gln Single submitter ⚠
- p.Arg528Cys Single submitter ⚠
- p.Arg99Gly Single submitter ⚠
- p.Asn376Lys Single submitter ⚠
- p.Asn37Ser Single submitter ⚠
- p.Asn467Asp Single submitter ⚠
- p.Asp254Asn Single submitter ⚠
- p.Asp297Val Single submitter ⚠
- p.Asp332His Single submitter ⚠
- p.Asp332Tyr Single submitter ⚠
- p.Asp367Asn Single submitter ⚠
- p.Asp463Gly Single submitter ⚠
- p.Asp512Gly Single submitter ⚠
- p.Cys167Tyr Single submitter ⚠
- p.Cys27Ser Single submitter ⚠
- p.Gln337Arg Single submitter ⚠
- p.Glu11Gln Single submitter ⚠
- p.Glu231Val Single submitter ⚠
- p.Glu23Ala Single submitter ⚠
- p.Glu316Lys Single submitter ⚠
- p.Glu431Gln Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly109Glu Single submitter ⚠
- p.Gly10Asp Single submitter ⚠
- p.His146Tyr Single submitter ⚠
- p.His14Arg Single submitter ⚠
- p.His243Tyr Single submitter ⚠
- p.His333Arg Single submitter ⚠
- p.His333Leu Single submitter ⚠
- p.His335Pro Single submitter ⚠
- p.His341Arg Single submitter ⚠
- p.His365Arg Single submitter ⚠
- p.His465Arg Single submitter ⚠
- p.His517Tyr Single submitter ⚠
- p.Ile44Thr Single submitter ⚠
- p.Ile7Thr Single submitter ⚠
- p.Leu271Met Single submitter ⚠
- p.Leu395Ser Single submitter ⚠
- p.Leu398Pro Single submitter ⚠
- p.Leu64Val Single submitter ⚠
- p.Lys111Ile Single submitter ⚠
- p.Lys144Ile Single submitter ⚠
- p.Lys150Gln Single submitter ⚠
- p.Lys164Glu Single submitter ⚠
- p.Lys310Thr Single submitter ⚠
- p.Lys35Glu Single submitter ⚠
- p.Lys408Asn Single submitter ⚠
- p.Met462Ile Single submitter ⚠
- p.Phe353Leu Single submitter ⚠
- p.Phe379Val Single submitter ⚠
- p.Pro117Arg Single submitter ⚠
- p.Pro265Ser Single submitter ⚠
- p.Pro451Ala Single submitter ⚠
- p.Pro475Ser Single submitter ⚠
- p.Pro513Ser Single submitter ⚠
- p.Pro522Leu Single submitter ⚠
- p.Pro522Ser Single submitter ⚠
- p.Pro76Ser Single submitter ⚠
- p.Ser200Leu Single submitter ⚠
- p.Ser212Pro Single submitter ⚠
- p.Ser236Gly Single submitter ⚠
- p.Ser320Pro Single submitter ⚠
- p.Ser329Cys Single submitter ⚠
- p.Ser378Phe Single submitter ⚠
- p.Ser414Leu Single submitter ⚠
- p.Ser458Ala Single submitter ⚠
- p.Ser509Leu Single submitter ⚠
- p.Ser97Phe Single submitter ⚠
- p.Thr156Pro Single submitter ⚠
- p.Thr238Ile Single submitter ⚠
- p.Thr251Ser Single submitter ⚠
- p.Thr380Ile Single submitter ⚠
- p.Thr410Ile Single submitter ⚠
- p.Thr529Ser Single submitter ⚠
- p.Thr59Ala Single submitter ⚠
- p.Tyr292Asn Single submitter ⚠
- p.Tyr292His Single submitter ⚠
- p.Tyr470Cys Single submitter ⚠
- p.Tyr470Phe Single submitter ⚠
- p.Val114Met Single submitter ⚠
- p.Val287Met Single submitter ⚠
- p.Val295Ala Single submitter ⚠
- p.Val319Ala Single submitter ⚠
- p.Val326Leu Single submitter ⚠
- p.Val449Met Single submitter ⚠
- p.Val73Met Single submitter ⚠