CFL1 — 9 ClinVar variants
All ClinVar germline CFL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
1 Benign · 8 Uncertain significance
Full CFL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CFL1 p.Arg146Cys Uncertain significance Single submitter
- CFL1 p.Glu162Ala Uncertain significance Single submitter
- CFL1 p.Pro165Ala Uncertain significance Single submitter
- CFL1 p.Ser156Gly Uncertain significance Single submitter
- CFL1 p.Tyr68Cys Uncertain significance Single submitter
- CFL1 p.Tyr89Cys Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All CFL1 variants
Benign 1
- p.Asp66= Multiple submitters
Uncertain significance 8
- p.Arg146Cys Single submitter ⚠
- p.Asp66Asn Single submitter ⚠
- p.Glu162Ala Single submitter ⚠
- p.Pro165Ala Single submitter ⚠
- p.Ser156Gly Single submitter ⚠
- p.Tyr68Cys Single submitter ⚠
- p.Tyr89Cys Single submitter ⚠
- p.Val60Met Single submitter ⚠