CGB2 — 36 ClinVar variants
All ClinVar germline CGB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
1 Benign · 6 Likely benign · 29 Uncertain significance
Full CGB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CGB2 p.Ala141Gly Uncertain significance Single submitter
- CGB2 p.Arg24Gln Uncertain significance Single submitter
- CGB2 p.Arg26Gln Uncertain significance Single submitter
- CGB2 p.Arg78Gly Uncertain significance Single submitter
- CGB2 p.Asn76Ser Uncertain significance Single submitter
- CGB2 p.Asp130Glu Uncertain significance Single submitter
- CGB2 p.Cys128Ser Uncertain significance Single submitter
- CGB2 p.Cys75Tyr Uncertain significance Single submitter
- CGB2 p.Gln107Lys Uncertain significance Single submitter
- CGB2 p.Glu83Gln Uncertain significance Single submitter
- CGB2 p.Gly15Arg Uncertain significance Single submitter
- CGB2 p.Leu110Phe Uncertain significance Single submitter
- CGB2 p.Met59Thr Uncertain significance Single submitter
- CGB2 p.Pro143Ser Uncertain significance Single submitter
- CGB2 p.Pro155Ser Uncertain significance Single submitter
- CGB2 p.Ser145Arg Uncertain significance Single submitter
- CGB2 p.Thr116Ile Uncertain significance Single submitter
- CGB2 p.Thr33Ile Uncertain significance Single submitter
- CGB2 p.Thr58Asn Uncertain significance Single submitter
- CGB2 p.Val43Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CGB2 p.Arg113Cys Uncertain significance Single submitter
- CGB2 p.Arg26Trp Uncertain significance Single submitter
- CGB2 p.Arg81His Uncertain significance Single submitter
- CGB2 p.Arg92Cys Uncertain significance Single submitter
- CGB2 p.Asn48Asp Uncertain significance Single submitter
- CGB2 p.Gly65Ala Likely benign Single submitter
- CGB2 p.Pro131His Uncertain significance Single submitter
- CGB2 p.Pro131Leu Uncertain significance Single submitter
- CGB2 p.Pro147Arg Uncertain significance Single submitter
- CGB2 p.Ser19Pro Uncertain significance Single submitter
All CGB2 variants
Benign 1
- p.Ala135Asp Multiple submitters
Likely benign 6
- p.Asn95Asp Single submitter
- p.Gln107Arg Single submitter
- p.Gln107His Single submitter
- p.Gly65Ala Single submitter ⚠
- p.Leu70Val Single submitter
- p.Ser156= Single submitter
Uncertain significance 29
- p.Ala141Gly Single submitter ⚠
- p.Arg113Cys Single submitter ⚠
- p.Arg24Gln Single submitter ⚠
- p.Arg26Gln Single submitter ⚠
- p.Arg26Trp Single submitter ⚠
- p.Arg78Gly Single submitter ⚠
- p.Arg81His Single submitter ⚠
- p.Arg92Cys Single submitter ⚠
- p.Asn48Asp Single submitter ⚠
- p.Asn76Ser Single submitter ⚠
- p.Asp130Glu Single submitter ⚠
- p.Cys128Ser Single submitter ⚠
- p.Cys75Tyr Single submitter ⚠
- p.Gln107Lys Single submitter ⚠
- p.Glu83Gln Single submitter ⚠
- p.Gly15Arg Single submitter ⚠
- p.Leu110Phe Single submitter ⚠
- p.Met59Thr Single submitter ⚠
- p.Pro131His Single submitter ⚠
- p.Pro131Leu Single submitter ⚠
- p.Pro143Ser Single submitter ⚠
- p.Pro147Arg Single submitter ⚠
- p.Pro155Ser Single submitter ⚠
- p.Ser145Arg Single submitter ⚠
- p.Ser19Pro Single submitter ⚠
- p.Thr116Ile Single submitter ⚠
- p.Thr33Ile Single submitter ⚠
- p.Thr58Asn Single submitter ⚠
- p.Val43Met Single submitter ⚠