CGB7 — 43 ClinVar variants
All ClinVar germline CGB7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
6 Likely benign · 37 Uncertain significance
Full CGB7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CGB7 p.Ala103Thr Uncertain significance Single submitter
- CGB7 p.Arg115His Uncertain significance Single submitter
- CGB7 p.Arg30Pro Uncertain significance Single submitter
- CGB7 p.Arg63Cys Uncertain significance Single submitter
- CGB7 p.Arg80Gly Uncertain significance Single submitter
- CGB7 p.Arg83Cys Uncertain significance Single submitter
- CGB7 p.Arg88Gln Uncertain significance Single submitter
- CGB7 p.Cys54Phe Uncertain significance Single submitter
- CGB7 p.Gly156Ala Uncertain significance Single submitter
- CGB7 p.Gly17Arg Uncertain significance Single submitter
- CGB7 p.Gly95Arg Uncertain significance Single submitter
- CGB7 p.Ile53Val Uncertain significance Single submitter
- CGB7 p.Leu112Phe Uncertain significance Single submitter
- CGB7 p.Leu25Pro Uncertain significance Single submitter
- CGB7 p.Met61Arg Uncertain significance Single submitter
- CGB7 p.Pro145Ala Uncertain significance Single submitter
- CGB7 p.Pro145Thr Uncertain significance Single submitter
- CGB7 p.Pro146Leu Uncertain significance Single submitter
- CGB7 p.Pro155Ser Uncertain significance Single submitter
- CGB7 p.Pro157Ser Uncertain significance Single submitter
- CGB7 p.Pro161Gln Uncertain significance Single submitter
- CGB7 p.Pro70Leu Uncertain significance Single submitter
- CGB7 p.Val104Gly Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CGB7 p.Arg30His Uncertain significance Single submitter
- CGB7 p.Arg80His Uncertain significance Single submitter
- CGB7 p.Arg88Trp Uncertain significance Single submitter
- CGB7 p.Gln109Leu Uncertain significance Single submitter
- CGB7 p.Glu85Lys Uncertain significance Single submitter
- CGB7 p.Gly95Asp Uncertain significance Single submitter
- CGB7 p.Leu9Met Uncertain significance Single submitter
- CGB7 p.Phe84Leu Uncertain significance Single submitter
- CGB7 p.Pro155Ala Uncertain significance Single submitter
- CGB7 p.Pro155Leu Likely benign Single submitter
- CGB7 p.Pro73Leu Uncertain significance Single submitter
- CGB7 p.Pro93Leu Uncertain significance Single submitter
- CGB7 p.Ser139Phe Uncertain significance Single submitter
- CGB7 p.Ser152Phe Uncertain significance Single submitter
- CGB7 p.Ser152Tyr Uncertain significance Single submitter
- CGB7 p.Val99Met Likely benign Single submitter
All CGB7 variants
Likely benign 6
- p.Asn78Thr Single submitter
- p.Gln109His Single submitter
- p.Pro155Leu Single submitter ⚠
- p.Pro31= Single submitter
- p.Val68Ala Single submitter
- p.Val99Met Single submitter ⚠
Uncertain significance 37
- p.Ala103Thr Single submitter ⚠
- p.Arg115His Single submitter ⚠
- p.Arg30His Single submitter ⚠
- p.Arg30Pro Single submitter ⚠
- p.Arg63Cys Single submitter ⚠
- p.Arg80Gly Single submitter ⚠
- p.Arg80His Single submitter ⚠
- p.Arg83Cys Single submitter ⚠
- p.Arg88Gln Single submitter ⚠
- p.Arg88Trp Single submitter ⚠
- p.Cys54Phe Single submitter ⚠
- p.Gln109Leu Single submitter ⚠
- p.Glu85Lys Single submitter ⚠
- p.Gly156Ala Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly95Arg Single submitter ⚠
- p.Gly95Asp Single submitter ⚠
- p.Ile53Val Single submitter ⚠
- p.Leu112Phe Single submitter ⚠
- p.Leu25Pro Single submitter ⚠
- p.Leu9Met Single submitter ⚠
- p.Met61Arg Single submitter ⚠
- p.Phe84Leu Single submitter ⚠
- p.Pro145Ala Single submitter ⚠
- p.Pro145Thr Single submitter ⚠
- p.Pro146Leu Single submitter ⚠
- p.Pro155Ala Single submitter ⚠
- p.Pro155Ser Single submitter ⚠
- p.Pro157Ser Single submitter ⚠
- p.Pro161Gln Single submitter ⚠
- p.Pro70Leu Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Pro93Leu Single submitter ⚠
- p.Ser139Phe Single submitter ⚠
- p.Ser152Phe Single submitter ⚠
- p.Ser152Tyr Single submitter ⚠
- p.Val104Gly Single submitter ⚠