CGB8 — 53 ClinVar variants
All ClinVar germline CGB8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
7 Likely benign · 46 Uncertain significance
Full CGB8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CGB8 p.Ala143Ser Uncertain significance Single submitter
- CGB8 p.Arg114His Uncertain significance Single submitter
- CGB8 p.Arg134Pro Uncertain significance Single submitter
- CGB8 p.Arg153Pro Uncertain significance Single submitter
- CGB8 p.Arg26Gln Uncertain significance Single submitter
- CGB8 p.Arg26Trp Uncertain significance Single submitter
- CGB8 p.Arg28Gln Uncertain significance Single submitter
- CGB8 p.Arg30His Uncertain significance Single submitter
- CGB8 p.Arg80His Uncertain significance Single submitter
- CGB8 p.Arg94His Uncertain significance Single submitter
- CGB8 p.Asp119Gly Uncertain significance Single submitter
- CGB8 p.Asp125Val Uncertain significance Single submitter
- CGB8 p.Gln109Glu Uncertain significance Single submitter
- CGB8 p.Gly17Arg Uncertain significance Single submitter
- CGB8 p.Gly6Glu Uncertain significance Single submitter
- CGB8 p.Gly95Asp Uncertain significance Single submitter
- CGB8 p.Ile47Leu Uncertain significance Single submitter
- CGB8 p.Met3Thr Uncertain significance Single submitter
- CGB8 p.Met61Val Uncertain significance Single submitter
- CGB8 p.Phe4Val Uncertain significance Single submitter
- CGB8 p.Pro127His Uncertain significance Single submitter
- CGB8 p.Pro133Thr Uncertain significance Single submitter
- CGB8 p.Pro145His Uncertain significance Single submitter
- CGB8 p.Pro145Leu Uncertain significance Single submitter
- CGB8 p.Pro151Leu Uncertain significance Single submitter
- CGB8 p.Pro155Arg Uncertain significance Single submitter
- CGB8 p.Pro161Arg Uncertain significance Single submitter
- CGB8 p.Pro161Leu Uncertain significance Single submitter
- CGB8 p.Pro24Leu Uncertain significance Single submitter
- CGB8 p.Pro27Leu Uncertain significance Single submitter
- CGB8 p.Pro70Arg Uncertain significance Single submitter
- CGB8 p.Pro93Leu Uncertain significance Single submitter
- CGB8 p.Ser138Phe Uncertain significance Single submitter
- CGB8 p.Ser14Asn Uncertain significance Single submitter
- CGB8 p.Ser150Arg Uncertain significance Single submitter
- CGB8 p.Thr129Ile Uncertain significance Single submitter
- CGB8 p.Val49Leu Uncertain significance Single submitter
- CGB8 p.Val75Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CGB8 variants
Likely benign 7
- p.Arg134His Single submitter
- p.Arg153= Single submitter
- p.Asn78Thr Single submitter
- p.Cys120= Single submitter
- p.Gly67Ala Single submitter
- p.Met15Val Single submitter
- p.Ser150= Single submitter
Uncertain significance 46
- p.Ala143Ser Single submitter ⚠
- p.Arg114His Single submitter ⚠
- p.Arg134Pro Single submitter ⚠
- p.Arg153Pro Single submitter ⚠
- p.Arg26Gln Single submitter ⚠
- p.Arg26Trp Single submitter ⚠
- p.Arg28Gln Single submitter ⚠
- p.Arg30His Single submitter ⚠
- p.Arg80His Single submitter ⚠
- p.Arg94Cys Single submitter
- p.Arg94His Single submitter ⚠
- p.Asn33Ser Single submitter ⚠
- p.Asp119Ala Single submitter ⚠
- p.Asp119Gly Single submitter ⚠
- p.Asp125Val Single submitter ⚠
- p.Gln109Glu Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly6Glu Single submitter ⚠
- p.Gly95Arg Single submitter
- p.Gly95Asp Single submitter ⚠
- p.Ile47Leu Single submitter ⚠
- p.Met3Thr Single submitter ⚠
- p.Met61Val Single submitter ⚠
- p.Phe4Val Single submitter ⚠
- p.Pro127His Single submitter ⚠
- p.Pro133Thr Single submitter ⚠
- p.Pro145His Single submitter ⚠
- p.Pro145Leu Single submitter ⚠
- p.Pro151Leu Single submitter ⚠
- p.Pro155Arg Single submitter ⚠
- p.Pro161Arg Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro27Leu Single submitter ⚠
- p.Pro70Arg Single submitter ⚠
- p.Pro93Leu Single submitter ⚠
- p.Ser107Asn Single submitter
- p.Ser138Phe Single submitter ⚠
- p.Ser14Asn Single submitter ⚠
- p.Ser150Arg Single submitter ⚠
- p.Thr129Ile Single submitter ⚠
- p.Val49Leu Single submitter ⚠
- p.Val64Met Single submitter ⚠
- p.Val75Met Single submitter ⚠
- p.Val82Ala Single submitter ⚠
- p.Val96Leu Single submitter