CGRRF1 — 37 ClinVar variants
All ClinVar germline CGRRF1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
2 Benign · 35 Uncertain significance
Full CGRRF1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CGRRF1 p.Ala125Thr Uncertain significance Single submitter
- CGRRF1 p.Ala218Thr Uncertain significance Single submitter
- CGRRF1 p.Asn233Asp Uncertain significance Single submitter
- CGRRF1 p.Asn234Asp Uncertain significance Single submitter
- CGRRF1 p.Asp157Glu Uncertain significance Single submitter
- CGRRF1 p.Asp250Gly Uncertain significance Single submitter
- CGRRF1 p.Asp93Ala Uncertain significance Single submitter
- CGRRF1 p.Gln304His Uncertain significance Single submitter
- CGRRF1 p.Glu127Asp Uncertain significance Single submitter
- CGRRF1 p.Glu255Gly Uncertain significance Single submitter
- CGRRF1 p.Glu269Asp Uncertain significance Single submitter
- CGRRF1 p.Glu49Asp Uncertain significance Single submitter
- CGRRF1 p.Ile43Leu Uncertain significance Single submitter
- CGRRF1 p.Leu107Phe Uncertain significance Single submitter
- CGRRF1 p.Leu286Phe Uncertain significance Single submitter
- CGRRF1 p.Leu86Trp Uncertain significance Single submitter
- CGRRF1 p.Lys113Asn Uncertain significance Single submitter
- CGRRF1 p.Ser169Cys Uncertain significance Single submitter
- CGRRF1 p.Ser267Leu Uncertain significance Single submitter
- CGRRF1 p.Thr158Ala Uncertain significance Single submitter
- CGRRF1 p.Thr158Asn Uncertain significance Single submitter
- CGRRF1 p.Thr249Arg Uncertain significance Single submitter
- CGRRF1 p.Thr54Ala Uncertain significance Single submitter
- CGRRF1 p.Thr87Ala Uncertain significance Single submitter
- CGRRF1 p.Thr97Ile Uncertain significance Single submitter
- CGRRF1 p.Tyr131His Uncertain significance Single submitter
- CGRRF1 p.Tyr188His Uncertain significance Single submitter
- CGRRF1 p.Val20Met Uncertain significance Single submitter
- CGRRF1 p.Val7Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CGRRF1 p.Ala3Val Uncertain significance Single submitter
- CGRRF1 p.Ile199Thr Uncertain significance Single submitter
- CGRRF1 p.Leu86Val Uncertain significance Single submitter
- CGRRF1 p.Leu95Pro Uncertain significance Single submitter
- CGRRF1 p.Pro14Leu Uncertain significance Single submitter
- CGRRF1 p.Pro167Ala Uncertain significance Single submitter
All CGRRF1 variants
Benign 2
- p.Arg185Trp Multiple submitters
- p.Pro329= Multiple submitters
Uncertain significance 35
- p.Ala125Thr Single submitter ⚠
- p.Ala218Thr Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Asn233Asp Single submitter ⚠
- p.Asn234Asp Single submitter ⚠
- p.Asp157Glu Single submitter ⚠
- p.Asp250Gly Single submitter ⚠
- p.Asp93Ala Single submitter ⚠
- p.Gln304His Single submitter ⚠
- p.Glu127Asp Single submitter ⚠
- p.Glu255Gly Single submitter ⚠
- p.Glu269Asp Single submitter ⚠
- p.Glu49Asp Single submitter ⚠
- p.Ile199Thr Single submitter ⚠
- p.Ile43Leu Single submitter ⚠
- p.Leu107Phe Single submitter ⚠
- p.Leu286Phe Single submitter ⚠
- p.Leu86Trp Single submitter ⚠
- p.Leu86Val Single submitter ⚠
- p.Leu95Pro Single submitter ⚠
- p.Lys113Asn Single submitter ⚠
- p.Pro14Leu Single submitter ⚠
- p.Pro167Ala Single submitter ⚠
- p.Ser169Cys Single submitter ⚠
- p.Ser267Leu Single submitter ⚠
- p.Thr158Ala Single submitter ⚠
- p.Thr158Asn Single submitter ⚠
- p.Thr249Arg Single submitter ⚠
- p.Thr54Ala Single submitter ⚠
- p.Thr87Ala Single submitter ⚠
- p.Thr97Ile Single submitter ⚠
- p.Tyr131His Single submitter ⚠
- p.Tyr188His Single submitter ⚠
- p.Val20Met Single submitter ⚠
- p.Val7Leu Single submitter ⚠