CH25H — 41 ClinVar variants
All ClinVar germline CH25H variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
1 Likely benign · 40 Uncertain significance
Full CH25H gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CH25H p.Ala271Glu Uncertain significance Single submitter
- CH25H p.Arg109Cys Uncertain significance Single submitter
- CH25H p.Arg272Gln Uncertain significance Single submitter
- CH25H p.Asn219Lys Uncertain significance Single submitter
- CH25H p.Asn249Thr Uncertain significance Single submitter
- CH25H p.Asp8Gly Uncertain significance Single submitter
- CH25H p.Cys13Phe Uncertain significance Single submitter
- CH25H p.Gln10Leu Uncertain significance Single submitter
- CH25H p.His160Arg Uncertain significance Single submitter
- CH25H p.His204Arg Uncertain significance Single submitter
- CH25H p.His204Gln Uncertain significance Single submitter
- CH25H p.Ile128Phe Uncertain significance Single submitter
- CH25H p.Ile208Thr Uncertain significance Single submitter
- CH25H p.Ile73Thr Uncertain significance Single submitter
- CH25H p.Met137Val Uncertain significance Single submitter
- CH25H p.Met187Val Uncertain significance Single submitter
- CH25H p.Pro86Leu Uncertain significance Single submitter
- CH25H p.Ser110Asn Uncertain significance Single submitter
- CH25H p.Ser63Cys Uncertain significance Single submitter
- CH25H p.Thr47Ala Uncertain significance Single submitter
- CH25H p.Tyr233Asn Uncertain significance Single submitter
- CH25H p.Val11Ala Uncertain significance Single submitter
- CH25H p.Val205Met Uncertain significance Single submitter
- CH25H p.Val237Gly Uncertain significance Single submitter
- CH25H p.Val49Leu Uncertain significance Single submitter
- CH25H p.Val96Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CH25H p.Arg265Trp Uncertain significance Single submitter
- CH25H p.Gly217Ser Uncertain significance Single submitter
- CH25H p.Gly89Arg Uncertain significance Single submitter
- CH25H p.Leu105Met Uncertain significance Single submitter
- CH25H p.Lys72Arg Uncertain significance Single submitter
- CH25H p.Phe135Leu Uncertain significance Single submitter
- CH25H p.Pro22Thr Uncertain significance Single submitter
- CH25H p.Pro66Ser Uncertain significance Single submitter
- CH25H p.Ser175Gly Uncertain significance Single submitter
- CH25H p.Thr103Met Uncertain significance Single submitter
- CH25H p.Tyr71Cys Uncertain significance Single submitter
- CH25H p.Val190Leu Uncertain significance Single submitter
- CH25H p.Val49Met Uncertain significance Single submitter
- CH25H p.Val65Met Uncertain significance Single submitter
All CH25H variants
Likely benign 1
- p.Ser63Pro Single submitter
Uncertain significance 40
- p.Ala271Glu Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg265Trp Single submitter ⚠
- p.Arg272Gln Single submitter ⚠
- p.Asn219Lys Single submitter ⚠
- p.Asn249Thr Single submitter ⚠
- p.Asp8Gly Single submitter ⚠
- p.Cys13Phe Single submitter ⚠
- p.Gln10Leu Single submitter ⚠
- p.Gly217Ser Single submitter ⚠
- p.Gly89Arg Single submitter ⚠
- p.His160Arg Single submitter ⚠
- p.His204Arg Single submitter ⚠
- p.His204Gln Single submitter ⚠
- p.Ile128Phe Single submitter ⚠
- p.Ile208Thr Single submitter ⚠
- p.Ile73Thr Single submitter ⚠
- p.Leu105Met Single submitter ⚠
- p.Lys72Arg Single submitter ⚠
- p.Met137Val Single submitter ⚠
- p.Met187Val Single submitter ⚠
- p.Phe135Leu Single submitter ⚠
- p.Pro22Thr Single submitter ⚠
- p.Pro66Ser Single submitter ⚠
- p.Pro86Leu Single submitter ⚠
- p.Ser110Asn Single submitter ⚠
- p.Ser175Gly Single submitter ⚠
- p.Ser63Cys Single submitter ⚠
- p.Thr103Met Single submitter ⚠
- p.Thr47Ala Single submitter ⚠
- p.Tyr233Asn Single submitter ⚠
- p.Tyr71Cys Single submitter ⚠
- p.Val11Ala Single submitter ⚠
- p.Val190Leu Single submitter ⚠
- p.Val205Met Single submitter ⚠
- p.Val237Gly Single submitter ⚠
- p.Val49Leu Single submitter ⚠
- p.Val49Met Single submitter ⚠
- p.Val65Met Single submitter ⚠
- p.Val96Ala Single submitter ⚠