CHERP — 104 ClinVar variants
All ClinVar germline CHERP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
7 Likely benign · 97 Uncertain significance
Full CHERP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHERP p.Ala125Glu Uncertain significance Single submitter
- CHERP p.Ala125Thr Uncertain significance Single submitter
- CHERP p.Ala125Val Uncertain significance Single submitter
- CHERP p.Ala403Gly Uncertain significance Single submitter
- CHERP p.Ala61Val Uncertain significance Single submitter
- CHERP p.Ala831Val Uncertain significance Single submitter
- CHERP p.Ala93Thr Uncertain significance Single submitter
- CHERP p.Ala94Val Uncertain significance Single submitter
- CHERP p.Arg231Gln Uncertain significance Single submitter
- CHERP p.Arg467His Uncertain significance Single submitter
- CHERP p.Arg570His Uncertain significance Single submitter
- CHERP p.Arg726Lys Uncertain significance Single submitter
- CHERP p.Arg748His Uncertain significance Single submitter
- CHERP p.Arg748Ser Uncertain significance Single submitter
- CHERP p.Arg784Trp Uncertain significance Single submitter
- CHERP p.Arg788Cys Uncertain significance Single submitter
- CHERP p.Arg793His Uncertain significance Single submitter
- CHERP p.Arg795Trp Uncertain significance Single submitter
- CHERP p.Arg811His Uncertain significance Single submitter
- CHERP p.Arg811Leu Uncertain significance Single submitter
- CHERP p.Arg814Gln Uncertain significance Single submitter
- CHERP p.Arg814Trp Uncertain significance Single submitter
- CHERP p.Asn183Ser Uncertain significance Single submitter
- CHERP p.Asn297Asp Uncertain significance Single submitter
- CHERP p.Asn536Ser Uncertain significance Single submitter
- CHERP p.Asn644Ser Uncertain significance Single submitter
- CHERP p.Asn900Ser Uncertain significance Single submitter
- CHERP p.Asp412Ala Uncertain significance Single submitter
- CHERP p.Asp412Asn Uncertain significance Single submitter
- CHERP p.Asp8Gly Uncertain significance Single submitter
- CHERP p.Cys915Tyr Uncertain significance Single submitter
- CHERP p.Gln265Leu Uncertain significance Single submitter
- CHERP p.Gln483His Uncertain significance Single submitter
- CHERP p.Gln71Arg Uncertain significance Single submitter
- CHERP p.Glu914Lys Uncertain significance Single submitter
- CHERP p.Gly468Ser Uncertain significance Single submitter
- CHERP p.Gly474Ser Uncertain significance Single submitter
- CHERP p.Gly728Ala Uncertain significance Single submitter
- CHERP p.Gly728Val Uncertain significance Single submitter
- CHERP p.Gly762Asp Uncertain significance Single submitter
- CHERP p.His137Arg Uncertain significance Single submitter
- CHERP p.His540Leu Uncertain significance Single submitter
- CHERP p.Ile314Phe Uncertain significance Single submitter
- CHERP p.Lys145Asn Uncertain significance Single submitter
- CHERP p.Lys59Arg Uncertain significance Single submitter
- CHERP p.Met347Leu Uncertain significance Single submitter
- CHERP p.Pro188Leu Uncertain significance Single submitter
- CHERP p.Pro357Ser Uncertain significance Single submitter
- CHERP p.Pro362Leu Uncertain significance Single submitter
- CHERP p.Pro366Ser Uncertain significance Single submitter
- CHERP p.Pro376Ser Uncertain significance Single submitter
- CHERP p.Pro400Leu Uncertain significance Single submitter
- CHERP p.Pro416Ala Uncertain significance Single submitter
- CHERP p.Pro437Ser Uncertain significance Single submitter
- CHERP p.Pro443Leu Uncertain significance Single submitter
- CHERP p.Pro512Ser Uncertain significance Single submitter
- CHERP p.Pro541Leu Uncertain significance Single submitter
- CHERP p.Pro561His Uncertain significance Single submitter
- CHERP p.Pro86Thr Uncertain significance Single submitter
- CHERP p.Pro97Leu Uncertain significance Single submitter
- CHERP p.Pro98Leu Uncertain significance Single submitter
- CHERP p.Ser734Arg Uncertain significance Single submitter
- CHERP p.Ser823Pro Uncertain significance Single submitter
- CHERP p.Ser830Leu Uncertain significance Single submitter
- CHERP p.Thr819Ser Uncertain significance Single submitter
- CHERP p.Tyr391Cys Uncertain significance Single submitter
- CHERP p.Val876Ile Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- CHERP p.Ala175Val Uncertain significance Single submitter
- CHERP p.Ala367Asp Uncertain significance Single submitter
- CHERP p.Arg740Gln Uncertain significance Single submitter
- CHERP p.Arg770His Uncertain significance Single submitter
- CHERP p.Arg774Cys Uncertain significance Single submitter
- CHERP p.Arg774His Uncertain significance Single submitter
- CHERP p.Arg778Cys Uncertain significance Single submitter
- CHERP p.Arg795Gln Uncertain significance Single submitter
- CHERP p.Asp166Asn Uncertain significance Single submitter
- CHERP p.Gln336His Uncertain significance Single submitter
- CHERP p.Glu465Lys Uncertain significance Single submitter
- CHERP p.His529Arg Uncertain significance Single submitter
- CHERP p.Lys32Asn Uncertain significance Single submitter
- CHERP p.Met193Ile Uncertain significance Single submitter
- CHERP p.Met516Ile Uncertain significance Single submitter
- CHERP p.Phe157Leu Uncertain significance Single submitter
- CHERP p.Pro358Arg Uncertain significance Single submitter
- CHERP p.Pro454Arg Uncertain significance Single submitter
- CHERP p.Pro585Ser Uncertain significance Single submitter
- CHERP p.Pro616Arg Uncertain significance Single submitter
- CHERP p.Pro616Leu Uncertain significance Single submitter
- CHERP p.Pro631Leu Uncertain significance Single submitter
- CHERP p.Ser749Phe Uncertain significance Single submitter
- CHERP p.Ser769Leu Uncertain significance Single submitter
- CHERP p.Val306Met Uncertain significance Single submitter
- CHERP p.Val659Met Uncertain significance Single submitter
All CHERP variants
Likely benign 7
- p.Ala102Thr Single submitter
- p.Asn482Ser Single submitter
- p.Gly395= Single submitter
- p.Gly885= Single submitter
- p.Ile260= Single submitter
- p.Pro539= Single submitter
- p.Ser763= Single submitter
Uncertain significance 97
- c.675-3_675-2del Single submitter
- p.Ala125Glu Single submitter ⚠
- p.Ala125Thr Single submitter ⚠
- p.Ala125Val Single submitter ⚠
- p.Ala175Val Single submitter ⚠
- p.Ala367Asp Single submitter ⚠
- p.Ala403Gly Single submitter ⚠
- p.Ala61Val Single submitter ⚠
- p.Ala831Val Single submitter ⚠
- p.Ala93Thr Single submitter ⚠
- p.Ala94Val Single submitter ⚠
- p.Arg231Gln Single submitter ⚠
- p.Arg467His Single submitter ⚠
- p.Arg570His Single submitter ⚠
- p.Arg726Lys Single submitter ⚠
- p.Arg740Gln Single submitter ⚠
- p.Arg748His Single submitter ⚠
- p.Arg748Ser Single submitter ⚠
- p.Arg770His Single submitter ⚠
- p.Arg774Cys Single submitter ⚠
- p.Arg774His Single submitter ⚠
- p.Arg778Cys Single submitter ⚠
- p.Arg784Trp Single submitter ⚠
- p.Arg788Cys Single submitter ⚠
- p.Arg793His Single submitter ⚠
- p.Arg795Gln Single submitter ⚠
- p.Arg795Trp Single submitter ⚠
- p.Arg811His Single submitter ⚠
- p.Arg811Leu Single submitter ⚠
- p.Arg814Gln Single submitter ⚠
- p.Arg814Trp Single submitter ⚠
- p.Asn183Ser Single submitter ⚠
- p.Asn297Asp Single submitter ⚠
- p.Asn536Ser Single submitter ⚠
- p.Asn644Ser Single submitter ⚠
- p.Asn900Ser Single submitter ⚠
- p.Asp166Asn Single submitter ⚠
- p.Asp412Ala Single submitter ⚠
- p.Asp412Asn Single submitter ⚠
- p.Asp572Asn Single submitter
- p.Asp8Gly Single submitter ⚠
- p.Cys915Tyr Single submitter ⚠
- p.Gln265Leu Single submitter ⚠
- p.Gln311Arg Single submitter
- p.Gln336His Single submitter ⚠
- p.Gln483His Single submitter ⚠
- p.Gln71Arg Single submitter ⚠
- p.Glu465Lys Single submitter ⚠
- p.Glu914Lys Single submitter ⚠
- p.Gly468Ser Single submitter ⚠
- p.Gly474Ser Single submitter ⚠
- p.Gly728Ala Single submitter ⚠
- p.Gly728Val Single submitter ⚠
- p.Gly762Asp Single submitter ⚠
- p.His137Arg Single submitter ⚠
- p.His529Arg Single submitter ⚠
- p.His540Leu Single submitter ⚠
- p.Ile314Phe Single submitter ⚠
- p.Lys145Asn Single submitter ⚠
- p.Lys32Asn Single submitter ⚠
- p.Lys59Arg Single submitter ⚠
- p.Met193Ile Single submitter ⚠
- p.Met347Leu Single submitter ⚠
- p.Met516Ile Single submitter ⚠
- p.Phe157Leu Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Pro357Ser Single submitter ⚠
- p.Pro358Arg Single submitter ⚠
- p.Pro362Leu Single submitter ⚠
- p.Pro366Ser Single submitter ⚠
- p.Pro376Ser Single submitter ⚠
- p.Pro400Leu Single submitter ⚠
- p.Pro416Ala Single submitter ⚠
- p.Pro437Ser Single submitter ⚠
- p.Pro443Leu Single submitter ⚠
- p.Pro454Arg Single submitter ⚠
- p.Pro512Ser Single submitter ⚠
- p.Pro541Leu Single submitter ⚠
- p.Pro561His Single submitter ⚠
- p.Pro566Leu Single submitter
- p.Pro585Ser Single submitter ⚠
- p.Pro616Arg Single submitter ⚠
- p.Pro616Leu Single submitter ⚠
- p.Pro631Leu Single submitter ⚠
- p.Pro86Thr Single submitter ⚠
- p.Pro97Leu Single submitter ⚠
- p.Pro98Leu Single submitter ⚠
- p.Ser734Arg Single submitter ⚠
- p.Ser749Phe Single submitter ⚠
- p.Ser769Leu Single submitter ⚠
- p.Ser823Pro Single submitter ⚠
- p.Ser830Leu Single submitter ⚠
- p.Thr819Ser Single submitter ⚠
- p.Tyr391Cys Single submitter ⚠
- p.Val306Met Single submitter ⚠
- p.Val659Met Single submitter ⚠
- p.Val876Ile Single submitter ⚠