CHI3L2 — 62 ClinVar variants
All ClinVar germline CHI3L2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
2 Benign · 1 Benign/Likely benign · 3 Likely benign · 56 Uncertain significance
Full CHI3L2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHI3L2 p.Gln196Glu Uncertain significance Single submitter
- CHI3L2 p.Glu67Lys Uncertain significance Single submitter
- CHI3L2 p.Gly290Arg Uncertain significance Single submitter
- CHI3L2 p.Ile362Val Uncertain significance Single submitter
- CHI3L2 p.Ile73Phe Uncertain significance Single submitter
- CHI3L2 p.Lys199Asn Uncertain significance Single submitter
- CHI3L2 p.Lys384Arg Uncertain significance Single submitter
- CHI3L2 p.Met264Leu Uncertain significance Single submitter
- CHI3L2 p.Ser240Arg Uncertain significance Single submitter
- CHI3L2 p.Ser341Arg Uncertain significance Single submitter
- CHI3L2 p.Thr171Lys Uncertain significance Single submitter
- CHI3L2 p.Thr4Asn Uncertain significance Single submitter
- CHI3L2 p.Trp234Leu Uncertain significance Single submitter
- CHI3L2 p.Trp252Arg Uncertain significance Single submitter
Predictors split 42
The independent predictors disagree with each other — read with care.
- CHI3L2 p.Val184Ile Benign/Likely benign Multiple submitters
- CHI3L2 p.Ala292Thr Uncertain significance Single submitter
- CHI3L2 p.Ala327Thr Uncertain significance Single submitter
- CHI3L2 p.Ala327Val Uncertain significance Single submitter
- CHI3L2 p.Ala64Thr Uncertain significance Single submitter
- CHI3L2 p.Arg385Gly Uncertain significance Single submitter
- CHI3L2 p.Arg40Trp Uncertain significance Single submitter
- CHI3L2 p.Asn136Lys Uncertain significance Single submitter
- CHI3L2 p.Asp236Ala Uncertain significance Single submitter
- CHI3L2 p.Asp321Tyr Uncertain significance Single submitter
- CHI3L2 p.Cys372Gly Uncertain significance Single submitter
- CHI3L2 p.Gln374Lys Uncertain significance Single submitter
- CHI3L2 p.Gln83His Uncertain significance Single submitter
- CHI3L2 p.Gly107Val Uncertain significance Single submitter
- CHI3L2 p.Gly238Arg Uncertain significance Single submitter
- CHI3L2 p.Gly23Glu Uncertain significance Single submitter
- CHI3L2 p.Gly300Ala Uncertain significance Single submitter
- CHI3L2 p.His215Arg Uncertain significance Single submitter
- CHI3L2 p.Ile129Thr Uncertain significance Single submitter
- CHI3L2 p.Ile253Met Uncertain significance Single submitter
- CHI3L2 p.Ile51Thr Uncertain significance Single submitter
- CHI3L2 p.Ile97Asn Uncertain significance Single submitter
- CHI3L2 p.Leu11Ile Uncertain significance Single submitter
- CHI3L2 p.Leu20Phe Uncertain significance Single submitter
- CHI3L2 p.Leu29Val Uncertain significance Single submitter
- CHI3L2 p.Lys315Met Uncertain significance Single submitter
- CHI3L2 p.Lys76Glu Uncertain significance Single submitter
- CHI3L2 p.Met114Ile Uncertain significance Single submitter
- CHI3L2 p.Met342Thr Uncertain significance Single submitter
- CHI3L2 p.Phe106Leu Uncertain significance Single submitter
- CHI3L2 p.Pro258Leu Uncertain significance Single submitter
- CHI3L2 p.Pro289Ser Uncertain significance Single submitter
- CHI3L2 p.Pro93Thr Uncertain significance Single submitter
- CHI3L2 p.Ser173Phe Uncertain significance Single submitter
- CHI3L2 p.Ser25Tyr Uncertain significance Single submitter
- CHI3L2 p.Ser277Phe Uncertain significance Single submitter
- CHI3L2 p.Ser341Asn Uncertain significance Single submitter
- CHI3L2 p.Ser386Asn Uncertain significance Single submitter
- CHI3L2 p.Ser57Pro Uncertain significance Single submitter
- CHI3L2 p.Ser62Leu Uncertain significance Single submitter
- CHI3L2 p.Thr296Ala Uncertain significance Single submitter
- CHI3L2 p.Thr317Met Uncertain significance Single submitter
All CHI3L2 variants
Benign 2
- p.Arg318Trp Multiple submitters
- p.Leu390= Multiple submitters
Benign/Likely benign 1
- p.Val184Ile Multiple submitters ⚠
Likely benign 3
- p.Gly110= Single submitter
- p.Leu88= Single submitter
- p.Val142Ile Single submitter
Uncertain significance 56
- p.Ala292Thr Single submitter ⚠
- p.Ala327Thr Single submitter ⚠
- p.Ala327Val Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Arg385Gly Single submitter ⚠
- p.Arg40Trp Single submitter ⚠
- p.Asn136Lys Single submitter ⚠
- p.Asp236Ala Single submitter ⚠
- p.Asp321Tyr Single submitter ⚠
- p.Cys372Gly Single submitter ⚠
- p.Gln196Glu Single submitter ⚠
- p.Gln374Lys Single submitter ⚠
- p.Gln83His Single submitter ⚠
- p.Glu67Lys Single submitter ⚠
- p.Gly107Val Single submitter ⚠
- p.Gly238Arg Single submitter ⚠
- p.Gly23Glu Single submitter ⚠
- p.Gly290Arg Single submitter ⚠
- p.Gly300Ala Single submitter ⚠
- p.Gly388fs Single submitter
- p.His215Arg Single submitter ⚠
- p.Ile129Thr Single submitter ⚠
- p.Ile253Met Single submitter ⚠
- p.Ile362Val Single submitter ⚠
- p.Ile51Thr Single submitter ⚠
- p.Ile73Phe Single submitter ⚠
- p.Ile97Asn Single submitter ⚠
- p.Leu11Ile Single submitter ⚠
- p.Leu20Phe Single submitter ⚠
- p.Leu29Val Single submitter ⚠
- p.Lys199Asn Single submitter ⚠
- p.Lys315Met Single submitter ⚠
- p.Lys384Arg Single submitter ⚠
- p.Lys76Glu Single submitter ⚠
- p.Met114Ile Single submitter ⚠
- p.Met264Leu Single submitter ⚠
- p.Met342Thr Single submitter ⚠
- p.Phe106Leu Single submitter ⚠
- p.Pro258Leu Single submitter ⚠
- p.Pro289Ser Single submitter ⚠
- p.Pro93Thr Single submitter ⚠
- p.Ser173Phe Single submitter ⚠
- p.Ser240Arg Single submitter ⚠
- p.Ser25Tyr Single submitter ⚠
- p.Ser277Phe Single submitter ⚠
- p.Ser341Arg Single submitter ⚠
- p.Ser341Asn Single submitter ⚠
- p.Ser386Asn Single submitter ⚠
- p.Ser57Pro Single submitter ⚠
- p.Ser62Leu Single submitter ⚠
- p.Thr171Lys Single submitter ⚠
- p.Thr296Ala Single submitter ⚠
- p.Thr317Met Single submitter ⚠
- p.Thr4Asn Single submitter ⚠
- p.Trp234Leu Single submitter ⚠
- p.Trp252Arg Single submitter ⚠