CHIC1 — 24 ClinVar variants
All ClinVar germline CHIC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
24 Uncertain significance
Full CHIC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHIC1 p.Arg222Gln Uncertain significance Single submitter
- CHIC1 p.Arg74Trp Uncertain significance Single submitter
- CHIC1 p.Asp44Asn Uncertain significance Single submitter
- CHIC1 p.Glu24Ala Uncertain significance Single submitter
- CHIC1 p.Glu79Asp Uncertain significance Single submitter
- CHIC1 p.Leu215Val Uncertain significance Single submitter
- CHIC1 p.Lys143Arg Uncertain significance Single submitter
- CHIC1 p.Pro86Ala Uncertain significance Single submitter
- CHIC1 p.Ser35Leu Uncertain significance Single submitter
- CHIC1 p.Val113Ile Uncertain significance Single submitter
-
CHIC1 p.Pro111Ser
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 7
The independent predictors disagree with each other — read with care.
- CHIC1 p.Glu45Lys Uncertain significance Single submitter
- CHIC1 p.Glu50Gly Uncertain significance Single submitter
- CHIC1 p.Glu52Ala Uncertain significance Single submitter
- CHIC1 p.Glu55Gly Uncertain significance Single submitter
- CHIC1 p.Ile210Met Uncertain significance Single submitter
- CHIC1 p.Pro139Leu Uncertain significance Single submitter
- CHIC1 p.Ser77Arg Uncertain significance Single submitter
All CHIC1 variants
Uncertain significance 24
- p.Arg222Gln Single submitter ⚠
- p.Arg74Trp Single submitter ⚠
- p.Asn204Thr Single submitter
- p.Asp44Asn Single submitter ⚠
- p.Cys133Ser Single submitter
- p.Glu24Ala Single submitter ⚠
- p.Glu45Lys Single submitter ⚠
- p.Glu50Gly Single submitter ⚠
- p.Glu52Ala Single submitter ⚠
- p.Glu55Gly Single submitter ⚠
- p.Glu64_Glu68del Single submitter
- p.Glu79Asp Single submitter ⚠
- p.Ile210Met Single submitter ⚠
- p.Leu215Val Single submitter ⚠
- p.Lys143Arg Single submitter ⚠
- p.Pro139Leu Single submitter ⚠
- p.Pro86Ala Single submitter ⚠
- p.Pro86Leu Single submitter
- p.Pro86Ser Single submitter
- p.Ser35Leu Single submitter ⚠
- p.Ser77Arg Single submitter ⚠
- p.Thr170Ser Single submitter
- p.Val113Ile Single submitter ⚠
- p.Pro111Ser No assertion criteria prostate cancer ⚠