CHMP4C — 39 ClinVar variants
All ClinVar germline CHMP4C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Benign · 38 Uncertain significance
Full CHMP4C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHMP4C p.Ala115Thr Uncertain significance Single submitter
- CHMP4C p.Ala19Pro Uncertain significance Single submitter
- CHMP4C p.Ala65Thr Uncertain significance Single submitter
- CHMP4C p.Arg184His Uncertain significance Single submitter
- CHMP4C p.Arg208Gly Uncertain significance Single submitter
- CHMP4C p.Arg209Gln Uncertain significance Single submitter
- CHMP4C p.Arg211Gln Uncertain significance Single submitter
- CHMP4C p.Arg217Lys Uncertain significance Single submitter
- CHMP4C p.Arg74Ser Uncertain significance Single submitter
- CHMP4C p.Asn198Lys Uncertain significance Single submitter
- CHMP4C p.Asn45Ser Uncertain significance Single submitter
- CHMP4C p.Asn98Lys Uncertain significance Single submitter
- CHMP4C p.Asn98Ser Uncertain significance Single submitter
- CHMP4C p.Asp124Gly Uncertain significance Single submitter
- CHMP4C p.Asp157Asn Uncertain significance Single submitter
- CHMP4C p.Glu167Asp Uncertain significance Single submitter
- CHMP4C p.Gly110Ser Uncertain significance Single submitter
- CHMP4C p.Gly58Arg Uncertain significance Single submitter
- CHMP4C p.Ile183Thr Uncertain significance Single submitter
- CHMP4C p.Leu164Trp Uncertain significance Single submitter
- CHMP4C p.Leu86Phe Uncertain significance Single submitter
- CHMP4C p.Lys179Arg Uncertain significance Single submitter
- CHMP4C p.Lys3Thr Uncertain significance Single submitter
- CHMP4C p.Lys56Thr Uncertain significance Single submitter
- CHMP4C p.Met132Val Uncertain significance Single submitter
- CHMP4C p.Ser210Thr Uncertain significance Single submitter
- CHMP4C p.Thr103Ala Uncertain significance Single submitter
- CHMP4C p.Thr136Lys Uncertain significance Single submitter
- CHMP4C p.Thr233Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CHMP4C p.Arg74Met Uncertain significance Single submitter
- CHMP4C p.Asn102Lys Uncertain significance Single submitter
- CHMP4C p.Asp162Asn Uncertain significance Single submitter
- CHMP4C p.Gln40Glu Uncertain significance Single submitter
- CHMP4C p.Glu134Gly Uncertain significance Single submitter
- CHMP4C p.Glu174Lys Uncertain significance Single submitter
- CHMP4C p.Val188Met Uncertain significance Single submitter
All CHMP4C variants
Benign 1
- p.Ala232Thr Multiple submitters
Uncertain significance 38
- p.Ala115Thr Single submitter ⚠
- p.Ala19Pro Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Arg152Trp Single submitter
- p.Arg184His Single submitter ⚠
- p.Arg208Gly Single submitter ⚠
- p.Arg209Gln Single submitter ⚠
- p.Arg211Gln Single submitter ⚠
- p.Arg217Lys Single submitter ⚠
- p.Arg74Met Single submitter ⚠
- p.Arg74Ser Single submitter ⚠
- p.Asn102Lys Single submitter ⚠
- p.Asn198Lys Single submitter ⚠
- p.Asn45Ser Single submitter ⚠
- p.Asn98Lys Single submitter ⚠
- p.Asn98Ser Single submitter ⚠
- p.Asp124Gly Single submitter ⚠
- p.Asp157Asn Single submitter ⚠
- p.Asp162Asn Single submitter ⚠
- p.Gln40Glu Single submitter ⚠
- p.Glu134Gly Single submitter ⚠
- p.Glu167Asp Single submitter ⚠
- p.Glu174Lys Single submitter ⚠
- p.Gly110Ser Single submitter ⚠
- p.Gly58Arg Single submitter ⚠
- p.Ile183Thr Single submitter ⚠
- p.Leu164Trp Single submitter ⚠
- p.Leu86Phe Single submitter ⚠
- p.Lys179Arg Single submitter ⚠
- p.Lys3Thr Single submitter ⚠
- p.Lys56Thr Single submitter ⚠
- p.Met132Val Single submitter ⚠
- p.Pro189Leu Single submitter
- p.Ser210Thr Single submitter ⚠
- p.Thr103Ala Single submitter ⚠
- p.Thr136Lys Single submitter ⚠
- p.Thr233Ile Single submitter ⚠
- p.Val188Met Single submitter ⚠