CHMP7 — 60 ClinVar variants
All ClinVar germline CHMP7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
2 Benign · 58 Uncertain significance
Full CHMP7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHMP7 p.Ala12Gly Uncertain significance Single submitter
- CHMP7 p.Ala300Thr Uncertain significance Single submitter
- CHMP7 p.Ala327Thr Uncertain significance Single submitter
- CHMP7 p.Arg290Trp Uncertain significance Single submitter
- CHMP7 p.Arg311Trp Uncertain significance Single submitter
- CHMP7 p.Arg415Thr Uncertain significance Single submitter
- CHMP7 p.Arg83Cys Uncertain significance Single submitter
- CHMP7 p.Asp338Gly Uncertain significance Single submitter
- CHMP7 p.Cys191Trp Uncertain significance Single submitter
- CHMP7 p.Gln249Glu Uncertain significance Single submitter
- CHMP7 p.Gly433Glu Uncertain significance Single submitter
- CHMP7 p.Gly68Trp Uncertain significance Single submitter
- CHMP7 p.His299Tyr Uncertain significance Single submitter
- CHMP7 p.Leu387Val Uncertain significance Single submitter
- CHMP7 p.Lys343Arg Uncertain significance Single submitter
- CHMP7 p.Lys382Glu Uncertain significance Single submitter
- CHMP7 p.Lys393Arg Uncertain significance Single submitter
- CHMP7 p.Met111Ile Uncertain significance Single submitter
- CHMP7 p.Phe375Ile Uncertain significance Single submitter
- CHMP7 p.Pro130Leu Uncertain significance Single submitter
- CHMP7 p.Pro88Ala Uncertain significance Single submitter
- CHMP7 p.Ser173Phe Uncertain significance Single submitter
- CHMP7 p.Thr364Ser Uncertain significance Single submitter
- CHMP7 p.Val239Ile Uncertain significance Single submitter
- CHMP7 p.Val339Ile Uncertain significance Single submitter
- CHMP7 p.Val411Leu Uncertain significance Single submitter
- CHMP7 p.Val436Gly Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- CHMP7 p.Ala112Asp Uncertain significance Single submitter
- CHMP7 p.Ala146Thr Uncertain significance Single submitter
- CHMP7 p.Ala160Gly Uncertain significance Single submitter
- CHMP7 p.Ala17Thr Uncertain significance Single submitter
- CHMP7 p.Ala188Val Uncertain significance Single submitter
- CHMP7 p.Ala272Thr Uncertain significance Single submitter
- CHMP7 p.Arg101Gln Uncertain significance Single submitter
- CHMP7 p.Arg101Leu Uncertain significance Single submitter
- CHMP7 p.Arg209Ser Uncertain significance Single submitter
- CHMP7 p.Arg271Trp Uncertain significance Single submitter
- CHMP7 p.Asp310Glu Uncertain significance Single submitter
- CHMP7 p.Cys273Tyr Uncertain significance Single submitter
- CHMP7 p.Gln78Leu Uncertain significance Single submitter
- CHMP7 p.Glu256Lys Uncertain significance Single submitter
- CHMP7 p.Glu256Val Uncertain significance Single submitter
- CHMP7 p.Glu7Lys Uncertain significance Single submitter
- CHMP7 p.Glu9Lys Uncertain significance Single submitter
- CHMP7 p.Leu155Met Uncertain significance Single submitter
- CHMP7 p.Leu186His Uncertain significance Single submitter
- CHMP7 p.Leu280Gln Uncertain significance Single submitter
- CHMP7 p.Met31Leu Uncertain significance Single submitter
- CHMP7 p.Phe197Leu Uncertain significance Single submitter
- CHMP7 p.Pro192Leu Uncertain significance Single submitter
- CHMP7 p.Pro22Leu Uncertain significance Single submitter
- CHMP7 p.Pro448Leu Uncertain significance Single submitter
- CHMP7 p.Ser284Phe Uncertain significance Single submitter
- CHMP7 p.Ser431Pro Uncertain significance Single submitter
- CHMP7 p.Ser51Cys Uncertain significance Single submitter
- CHMP7 p.Tyr313Cys Uncertain significance Single submitter
- CHMP7 p.Val125Phe Uncertain significance Single submitter
- CHMP7 p.Val163Ala Uncertain significance Single submitter
All CHMP7 variants
Uncertain significance 58
- p.Ala112Asp Single submitter ⚠
- p.Ala12Gly Single submitter ⚠
- p.Ala146Thr Single submitter ⚠
- p.Ala160Gly Single submitter ⚠
- p.Ala17Thr Single submitter ⚠
- p.Ala188Val Single submitter ⚠
- p.Ala272Thr Single submitter ⚠
- p.Ala300Thr Single submitter ⚠
- p.Ala327Thr Single submitter ⚠
- p.Arg101Gln Single submitter ⚠
- p.Arg101Leu Single submitter ⚠
- p.Arg209Ser Single submitter ⚠
- p.Arg271Trp Single submitter ⚠
- p.Arg290Trp Single submitter ⚠
- p.Arg311Trp Single submitter ⚠
- p.Arg415Thr Single submitter ⚠
- p.Arg83Cys Single submitter ⚠
- p.Asp310Glu Single submitter ⚠
- p.Asp338Gly Single submitter ⚠
- p.Cys191Trp Single submitter ⚠
- p.Cys273Tyr Single submitter ⚠
- p.Gln249Glu Single submitter ⚠
- p.Gln78Leu Single submitter ⚠
- p.Glu256Lys Single submitter ⚠
- p.Glu256Val Single submitter ⚠
- p.Glu7Lys Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly433Glu Single submitter ⚠
- p.Gly68Trp Single submitter ⚠
- p.His299Tyr Single submitter ⚠
- p.Leu155Met Single submitter ⚠
- p.Leu186His Single submitter ⚠
- p.Leu280Gln Single submitter ⚠
- p.Leu387Val Single submitter ⚠
- p.Lys343Arg Single submitter ⚠
- p.Lys382Glu Single submitter ⚠
- p.Lys393Arg Single submitter ⚠
- p.Met111Ile Single submitter ⚠
- p.Met31Leu Single submitter ⚠
- p.Phe197Leu Single submitter ⚠
- p.Phe375Ile Single submitter ⚠
- p.Pro130Leu Single submitter ⚠
- p.Pro192Leu Single submitter ⚠
- p.Pro22Leu Single submitter ⚠
- p.Pro448Leu Single submitter ⚠
- p.Pro88Ala Single submitter ⚠
- p.Ser173Phe Single submitter ⚠
- p.Ser284Phe Single submitter ⚠
- p.Ser431Pro Single submitter ⚠
- p.Ser51Cys Single submitter ⚠
- p.Thr364Ser Single submitter ⚠
- p.Tyr313Cys Single submitter ⚠
- p.Val125Phe Single submitter ⚠
- p.Val163Ala Single submitter ⚠
- p.Val239Ile Single submitter ⚠
- p.Val339Ile Single submitter ⚠
- p.Val411Leu Single submitter ⚠
- p.Val436Gly Single submitter ⚠