CHORDC1 — 35 ClinVar variants
All ClinVar germline CHORDC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
35 Uncertain significance
Full CHORDC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHORDC1 p.Arg290Gln Uncertain significance Single submitter
- CHORDC1 p.Gln278Glu Uncertain significance Single submitter
- CHORDC1 p.Glu146Asp Uncertain significance Single submitter
- CHORDC1 p.His34Gln Uncertain significance Single submitter
- CHORDC1 p.Ile153Thr Uncertain significance Single submitter
- CHORDC1 p.Ile184Val Uncertain significance Single submitter
- CHORDC1 p.Leu130Val Uncertain significance Single submitter
- CHORDC1 p.Lys321Glu Uncertain significance Single submitter
- CHORDC1 p.Lys325Glu Uncertain significance Single submitter
- CHORDC1 p.Lys38Glu Uncertain significance Single submitter
- CHORDC1 p.Met115Leu Uncertain significance Single submitter
- CHORDC1 p.Met115Val Uncertain significance Single submitter
- CHORDC1 p.Pro102Ser Uncertain significance Single submitter
- CHORDC1 p.Ser20Ala Uncertain significance Single submitter
- CHORDC1 p.Ser41Ala Uncertain significance Single submitter
- CHORDC1 p.Thr303Ser Uncertain significance Single submitter
- CHORDC1 p.Thr330Ala Uncertain significance Single submitter
- CHORDC1 p.Val280Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CHORDC1 p.Ala23Gly Uncertain significance Single submitter
- CHORDC1 p.Ala2Pro Uncertain significance Single submitter
- CHORDC1 p.Arg13His Uncertain significance Single submitter
- CHORDC1 p.Asp112Glu Uncertain significance Single submitter
- CHORDC1 p.Asp15Gly Uncertain significance Single submitter
- CHORDC1 p.Asp15Tyr Uncertain significance Single submitter
- CHORDC1 p.Asp328Tyr Uncertain significance Single submitter
- CHORDC1 p.Gln128Arg Uncertain significance Single submitter
- CHORDC1 p.Leu120Ser Uncertain significance Single submitter
- CHORDC1 p.Leu3Met Uncertain significance Single submitter
- CHORDC1 p.Lys220Arg Uncertain significance Single submitter
- CHORDC1 p.Met295Val Uncertain significance Single submitter
- CHORDC1 p.Pro90Leu Uncertain significance Single submitter
- CHORDC1 p.Thr298Ala Uncertain significance Single submitter
- CHORDC1 p.Tyr178Cys Uncertain significance Single submitter
- CHORDC1 p.Val228Ala Uncertain significance Single submitter
- CHORDC1 p.Val293Ile Uncertain significance Single submitter
All CHORDC1 variants
Uncertain significance 35
- p.Ala23Gly Single submitter ⚠
- p.Ala2Pro Single submitter ⚠
- p.Arg13His Single submitter ⚠
- p.Arg290Gln Single submitter ⚠
- p.Asp112Glu Single submitter ⚠
- p.Asp15Gly Single submitter ⚠
- p.Asp15Tyr Single submitter ⚠
- p.Asp328Tyr Single submitter ⚠
- p.Gln128Arg Single submitter ⚠
- p.Gln278Glu Single submitter ⚠
- p.Glu146Asp Single submitter ⚠
- p.His34Gln Single submitter ⚠
- p.Ile153Thr Single submitter ⚠
- p.Ile184Val Single submitter ⚠
- p.Leu120Ser Single submitter ⚠
- p.Leu130Val Single submitter ⚠
- p.Leu3Met Single submitter ⚠
- p.Lys220Arg Single submitter ⚠
- p.Lys321Glu Single submitter ⚠
- p.Lys325Glu Single submitter ⚠
- p.Lys38Glu Single submitter ⚠
- p.Met115Leu Single submitter ⚠
- p.Met115Val Single submitter ⚠
- p.Met295Val Single submitter ⚠
- p.Pro102Ser Single submitter ⚠
- p.Pro90Leu Single submitter ⚠
- p.Ser20Ala Single submitter ⚠
- p.Ser41Ala Single submitter ⚠
- p.Thr298Ala Single submitter ⚠
- p.Thr303Ser Single submitter ⚠
- p.Thr330Ala Single submitter ⚠
- p.Tyr178Cys Single submitter ⚠
- p.Val228Ala Single submitter ⚠
- p.Val280Met Single submitter ⚠
- p.Val293Ile Single submitter ⚠