CHP2 — 41 ClinVar variants
All ClinVar germline CHP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
1 Likely benign · 40 Uncertain significance
Full CHP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHP2 p.Ala37Thr Uncertain significance Single submitter
- CHP2 p.Arg127His Uncertain significance Single submitter
- CHP2 p.Arg4His Uncertain significance Single submitter
- CHP2 p.Asp126Tyr Uncertain significance Single submitter
- CHP2 p.Asp95Asn Uncertain significance Single submitter
- CHP2 p.Asp97Asn Uncertain significance Single submitter
- CHP2 p.Glu99Asp Uncertain significance Single submitter
- CHP2 p.Gly129Arg Uncertain significance Single submitter
- CHP2 p.His89Tyr Uncertain significance Single submitter
- CHP2 p.Ile156Asn Uncertain significance Single submitter
- CHP2 p.Leu116Phe Uncertain significance Single submitter
- CHP2 p.Leu46Pro Uncertain significance Single submitter
- CHP2 p.Lys196Thr Uncertain significance Single submitter
- CHP2 p.Phe177Ser Uncertain significance Single submitter
- CHP2 p.Phe177Val Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CHP2 p.Arg159Cys Uncertain significance Single submitter
- CHP2 p.Arg159His Uncertain significance Single submitter
- CHP2 p.Arg193Gly Uncertain significance Single submitter
- CHP2 p.Arg30Cys Uncertain significance Single submitter
- CHP2 p.Arg30His Uncertain significance Single submitter
- CHP2 p.Arg36Trp Uncertain significance Single submitter
- CHP2 p.Arg48Cys Uncertain significance Single submitter
- CHP2 p.Arg65Gln Uncertain significance Single submitter
- CHP2 p.Arg77Gly Uncertain significance Single submitter
- CHP2 p.Arg91Cys Uncertain significance Single submitter
- CHP2 p.Asp128Asn Uncertain significance Single submitter
- CHP2 p.Asp79Tyr Uncertain significance Single submitter
- CHP2 p.Gly170Arg Uncertain significance Single submitter
- CHP2 p.Gly22Val Uncertain significance Single submitter
- CHP2 p.His32Arg Uncertain significance Single submitter
- CHP2 p.His33Tyr Uncertain significance Single submitter
- CHP2 p.His7Tyr Uncertain significance Single submitter
- CHP2 p.Ile67Thr Uncertain significance Single submitter
- CHP2 p.Leu195Val Uncertain significance Single submitter
- CHP2 p.Lys42Thr Uncertain significance Single submitter
- CHP2 p.Phe174Leu Uncertain significance Single submitter
- CHP2 p.Ser191Gly Uncertain significance Single submitter
- CHP2 p.Ser5Thr Uncertain significance Single submitter
- CHP2 p.Val144Ile Uncertain significance Single submitter
- CHP2 p.Val186Phe Uncertain significance Single submitter
All CHP2 variants
Likely benign 1
- p.Val186Ile Single submitter
Uncertain significance 40
- p.Ala37Thr Single submitter ⚠
- p.Arg127His Single submitter ⚠
- p.Arg159Cys Single submitter ⚠
- p.Arg159His Single submitter ⚠
- p.Arg193Gly Single submitter ⚠
- p.Arg30Cys Single submitter ⚠
- p.Arg30His Single submitter ⚠
- p.Arg36Trp Single submitter ⚠
- p.Arg48Cys Single submitter ⚠
- p.Arg4His Single submitter ⚠
- p.Arg65Gln Single submitter ⚠
- p.Arg77Gly Single submitter ⚠
- p.Arg91Cys Single submitter ⚠
- p.Asp126Tyr Single submitter ⚠
- p.Asp128Asn Single submitter ⚠
- p.Asp79Tyr Single submitter ⚠
- p.Asp95Asn Single submitter ⚠
- p.Asp97Asn Single submitter ⚠
- p.Glu99Asp Single submitter ⚠
- p.Gly129Arg Single submitter ⚠
- p.Gly170Arg Single submitter ⚠
- p.Gly22Val Single submitter ⚠
- p.His32Arg Single submitter ⚠
- p.His33Tyr Single submitter ⚠
- p.His7Tyr Single submitter ⚠
- p.His89Tyr Single submitter ⚠
- p.Ile156Asn Single submitter ⚠
- p.Ile67Thr Single submitter ⚠
- p.Leu116Phe Single submitter ⚠
- p.Leu195Val Single submitter ⚠
- p.Leu46Pro Single submitter ⚠
- p.Lys196Thr Single submitter ⚠
- p.Lys42Thr Single submitter ⚠
- p.Phe174Leu Single submitter ⚠
- p.Phe177Ser Single submitter ⚠
- p.Phe177Val Single submitter ⚠
- p.Ser191Gly Single submitter ⚠
- p.Ser5Thr Single submitter ⚠
- p.Val144Ile Single submitter ⚠
- p.Val186Phe Single submitter ⚠