CHRAC1 — 17 ClinVar variants
All ClinVar germline CHRAC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
1 Likely benign · 16 Uncertain significance
Full CHRAC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHRAC1 p.Asn120Lys Uncertain significance Single submitter
- CHRAC1 p.Gln54Glu Uncertain significance Single submitter
- CHRAC1 p.Gln83Arg Uncertain significance Single submitter
- CHRAC1 p.Glu113Lys Uncertain significance Single submitter
- CHRAC1 p.Glu13Gly Uncertain significance Single submitter
- CHRAC1 p.Glu33Asp Uncertain significance Single submitter
- CHRAC1 p.Leu19Val Uncertain significance Single submitter
- CHRAC1 p.Ser75Asn Uncertain significance Single submitter
- CHRAC1 p.Val43Met Uncertain significance Single submitter
- CHRAC1 p.Val4Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CHRAC1 p.Glu114Asp Likely benign Single submitter
- CHRAC1 p.Glu68Ala Uncertain significance Single submitter
- CHRAC1 p.Gly64Cys Uncertain significance Single submitter
- CHRAC1 p.Ile93Thr Uncertain significance Single submitter
- CHRAC1 p.Leu104Val Uncertain significance Single submitter
- CHRAC1 p.Lys69Thr Uncertain significance Single submitter
- CHRAC1 p.Tyr61Cys Uncertain significance Single submitter
All CHRAC1 variants
Likely benign 1
- p.Glu114Asp Single submitter ⚠
Uncertain significance 16
- p.Asn120Lys Single submitter ⚠
- p.Gln54Glu Single submitter ⚠
- p.Gln83Arg Single submitter ⚠
- p.Glu113Lys Single submitter ⚠
- p.Glu13Gly Single submitter ⚠
- p.Glu33Asp Single submitter ⚠
- p.Glu68Ala Single submitter ⚠
- p.Gly64Cys Single submitter ⚠
- p.Ile93Thr Single submitter ⚠
- p.Leu104Val Single submitter ⚠
- p.Leu19Val Single submitter ⚠
- p.Lys69Thr Single submitter ⚠
- p.Ser75Asn Single submitter ⚠
- p.Tyr61Cys Single submitter ⚠
- p.Val43Met Single submitter ⚠
- p.Val4Ala Single submitter ⚠