CHRM1 — 51 ClinVar variants
All ClinVar germline CHRM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
1 Likely pathogenic · 2 Benign · 5 Likely benign · 43 Uncertain significance
Full CHRM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CHRM1 p.Ala271Thr Uncertain significance Single submitter
- CHRM1 p.Arg137Cys Uncertain significance Single submitter
- CHRM1 p.Arg213Gln Uncertain significance Single submitter
- CHRM1 p.Arg334His Uncertain significance Single submitter
- CHRM1 p.Arg336Gln Uncertain significance Single submitter
- CHRM1 p.Arg344His Uncertain significance Single submitter
- CHRM1 p.Arg352Trp Uncertain significance Single submitter
- CHRM1 p.Arg441His Uncertain significance Single submitter
- CHRM1 p.Arg448His Uncertain significance Single submitter
- CHRM1 p.Asn80His Uncertain significance Single submitter
- CHRM1 p.Cys205Arg Uncertain significance Single submitter
- CHRM1 p.Cys259Phe Uncertain significance Single submitter
- CHRM1 p.Glu229Lys Uncertain significance Single submitter
- CHRM1 p.Gly147Ser Uncertain significance Single submitter
- CHRM1 p.Gly19Glu Uncertain significance Single submitter
- CHRM1 p.Gly283Val Uncertain significance Single submitter
- CHRM1 p.Gly297Cys Uncertain significance Single submitter
- CHRM1 p.Gly338Ser Uncertain significance Single submitter
- CHRM1 p.Leu371Phe Uncertain significance Single submitter
- CHRM1 p.Lys331Gln Uncertain significance Single submitter
- CHRM1 p.Lys353Arg Uncertain significance Single submitter
- CHRM1 p.Met306Lys Uncertain significance Single submitter
- CHRM1 p.Pro11Leu Uncertain significance Single submitter
- CHRM1 p.Pro231Ser Uncertain significance Single submitter
- CHRM1 p.Pro246Arg Uncertain significance Single submitter
- CHRM1 p.Pro246Leu Uncertain significance Single submitter
- CHRM1 p.Pro314Leu Uncertain significance Single submitter
- CHRM1 p.Pro314Thr Uncertain significance Single submitter
- CHRM1 p.Pro329Leu Uncertain significance Single submitter
- CHRM1 p.Pro456Leu Uncertain significance Single submitter
- CHRM1 p.Pro6Leu Uncertain significance Single submitter
- CHRM1 p.Ser457Thr Uncertain significance Single submitter
- CHRM1 p.Val203Ile Uncertain significance Single submitter
- CHRM1 p.Val409Ile Uncertain significance Single submitter
- CHRM1 p.Val452Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CHRM1 p.Ala26Asp Uncertain significance Single submitter
- CHRM1 p.Arg141Gln Uncertain significance Single submitter
- CHRM1 p.Arg426Gln Uncertain significance Single submitter
- CHRM1 p.Arg436His Uncertain significance Single submitter
- CHRM1 p.Cys69Tyr Uncertain significance Single submitter
- CHRM1 p.Leu222Val Uncertain significance Single submitter
- CHRM1 p.Thr138Ser Uncertain significance Single submitter
All CHRM1 variants
Likely pathogenic 1
- p.Phe425Ser Single submitter
Likely benign 5
Uncertain significance 43
- p.Ala26Asp Single submitter ⚠
- p.Ala271Thr Single submitter ⚠
- p.Arg137Cys Single submitter ⚠
- p.Arg141Gln Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg334His Single submitter ⚠
- p.Arg336Gln Single submitter ⚠
- p.Arg344His Single submitter ⚠
- p.Arg352Trp Single submitter ⚠
- p.Arg426Gln Single submitter ⚠
- p.Arg436His Single submitter ⚠
- p.Arg441His Single submitter ⚠
- p.Arg448His Single submitter ⚠
- p.Asn80His Single submitter ⚠
- p.Cys205Arg Single submitter ⚠
- p.Cys259Phe Single submitter ⚠
- p.Cys69Tyr Single submitter ⚠
- p.Glu229Lys Single submitter ⚠
- p.Gly147Ser Single submitter ⚠
- p.Gly19Glu Single submitter ⚠
- p.Gly283Val Single submitter ⚠
- p.Gly297Cys Single submitter ⚠
- p.Gly338Ser Single submitter ⚠
- p.Leu222Val Single submitter ⚠
- p.Leu371Phe Single submitter ⚠
- p.Lys331Gln Single submitter ⚠
- p.Lys353Arg Single submitter ⚠
- p.Met306Lys Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro231Ser Single submitter ⚠
- p.Pro246Arg Single submitter ⚠
- p.Pro246Leu Single submitter ⚠
- p.Pro314Leu Single submitter ⚠
- p.Pro314Thr Single submitter ⚠
- p.Pro329Leu Single submitter ⚠
- p.Pro456Leu Single submitter ⚠
- p.Pro6Leu Single submitter ⚠
- p.Ser457Thr Single submitter ⚠
- p.Thr138Ser Single submitter ⚠
- p.Thr206= Single submitter
- p.Val203Ile Single submitter ⚠
- p.Val409Ile Single submitter ⚠
- p.Val452Met Single submitter ⚠